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Biomedical subjects

H J Trojan

Publications and source records attributed to H J Trojan.

16 recordsLinked to original sources
PubMed2006

[Four plus one].

Explore the source record for details and available documents.

Blindness↗
PubMed1984

[Eye involvement in leprosy. A study in Togo, West Africa].

It is well known that ocular changes occur in leprosy, but data on their frequency differ very considerably (0.8-100%). Two groups of lepers in Togo were examined: first, 206 lepers who had had the disease for approximately 10 years and a second group (101) patients who had been suffering from it for approximately 24 years and had severe mutilations. It became apparent that sooner or later all lepers suffer from ocular complications. The following symptoms were found: loss of the eyebrows in 40.8% (42.6%), loss of the eyelashes in 29.6% (34.6%), lagophthalmos caused by involvement of the 7th cranial nerve in 21.4% (31.7%), corneal changes in 34.5% (49.5%), uveitis in 5.8% (19.8%), atrophy of the optic nerve in 12.6% (11.9%) and cataract in 21.8% (12.8%). The duration of the disease, the type of leprosy and the time when treatment was started are obviously the main factors associated with ocular changes in leprosy.

Adult↗
PubMed1983

Isolation of antigen from Litomosoides carinii macrofilariae detecting serum antibodies due to Onchocerca volvulus.

Crude aqueous Litomosoides carinii adult worm extract was used as antigen for the detection of antibodies in sera from African patients with proven onchocerciasis (n = 45) resident in rural endemic areas of Togo and Sierra Leone. In 71% of cases this extract was found to produce 1 to 5 precipitation arcs in immunoelectrophoresis. Using a crude aqueous extract from adult Onchocerca volvulus, precipitation tests were positive in 75% of cases. The complexity of the L. carinii crude extract was shown by PAG-disc electrophoresis, PAG-electrofocusing, immunoelectrophoresis and crossed immunoelectrophoresis with the appropriate rabbit-antiserum. An antigen detecting onchocercal antibodies was isolated by two step preparative flat bed electrofocusing in granulated gel (PEGG). The antigen (pI 6.55, molecular weight 55 to 60 kd as estimated by SDS-PAG electrophoresis) was very suitable for antibody demonstration in double diffusion test and immunoelectrophoresis. Preliminary controls for specificity were performed by diffusing the antigen against sera from human and animal helminthoses including filarial infections. In contrast to the crude L. carinii extract no reaction was observed with sera from helminthic infections others than filariasis.

Animals↗
PubMed1982

[Eye damage as a result of long-term malaria prophylaxis with chloroquine (author's transl)].

Several authors have reported corneal and retinal changes occurring during high-dosage application of chloroquine for the treatment of some internal and dermatological diseases (300-500 mg of the base daily). The critical limit seems to be application of a total of 100 g of the base of chloroquine. In malaria prophylaxis (300 mg of the base weekly) it will take six-and-a-half years to reach this limit. In the few reports (27 cases) of ocular damage following malaria prophylaxis, a hyperdosage became evident. People living for prolonged periods of time in areas where malaria is endemic should have regular ophthalmological examinations and the administration of chloroquine should be stopped at the slightest sign of ocular damage.

Adult↗
PubMed1979

[Aetiology and therapy of Mooren's ulcer (author's transl)].

A report is given of 34 cases of Ulcus rodens of the eye (Mooren), which were examined and treaded during a period of five years in Togo, West Africa. The cases were divided into two groups according to the development of the disease. In fourteen cases the progress of the disease was arrested by local treatment (described individually for each eye), and by simultaneous treatment of the Helminthosis (Ascaris lumbricoides and Ankylostoma duodenale), from which the patients were also suffering. It seems likely that Ulcus rodens is caused by an antigen-antibody reaction to Helminth toxins.

Adolescent↗