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Biomedical subjects

H J Soost

Publications and source records attributed to H J Soost.

At least 37 records · Page 2Linked to original sources
PubMed1977

[Prescreening methods for gynecological cytology (author's transl)].

In cytological investigations to trace gynecological cancer a large number of preparations must be examined in order to discover a small number of positive and suspicious findings. In 1974, 5.5 million investigations were carried out in the German Federal Republic, of which 2% positive, 9.2% suspicious and 2.4% technically useless cytological results were obtained. 98.64% of the cytological results were negative. Consequently in different parts of the world efforts are being made to automate the preliminary microscopic sampling of the cytological preparations. False negative cytological findings must be no higher than in conventional diagnosis (without extraction error approximately 5%), while false positive cytological findings (in conventional diagnosis less than 1%) may be higher, because they can be classified correctly on subsequent assessment.

Adolescent↗
PubMed1976

[Cytological diagnosis of endometrial carcinoma].

Because of increase of endometrial carcinoma the frequency rate of invasive cervix carcinoma and carcinoma of uterine corpus has been changing in the last ten years and at several places in the world it is approaching 1:1. That shows the importance of early detection of endometrial carcinoma. A summary of cytology diagnostic of normal and pathological endometrium is given. Especially it is pointed to the great difference between the cytomorphical cell criteria of endometrial malignancies dependent on the differentiation grade of endometrial carcinoma. The predominance of cell atypia is found by the undifferentiated carcinoma of uterine corpus whereas the cells of frequently found well differentiated endometrial carcinoma often cannot be differentiated from normal endometrium cells. The observation of cells of endometrial carcinoma in normal cellular samples of cervix and vagina is no more than 60--70 percent; at this rate the endocervical aspiration has the greatest chance of detection. To correct the early cellular diagnosis of uterine carcinoma the appearance of normal endometrium cells by screening must be noticed and each finding at an untypical moment, for example in postmenopause, must be an alarm signal. The different intrauterine aspiration techniques obtained more than 90 percent accuracy in the detection of endometrial carcinoma. This method is qualified for special indications in a limited number of cases.

Adenocarcinoma↗
PubMed1976

[Do cytological criteria exist to determine the correct technique of a cytosmear of the uterine cervix? (author's transl)].

The objective of this study was to determine whether the presence or absence of endocervical and/or metaplastic cells in a pap smear from the uterine cervix is indicative that the smear has been obtained from the correct location. Cytosmears from positive cytological findings were compared with cytosmears from correct negative and false negative findings for the presence of endocervical and/or metaplastic cell types. It was found that smears with positive findings showed no endocervical and or metaplastic cells in 25-30% of the cases of carcinoma in situ or dysplasia and in 75% of the cases of invasive carcinoma. False negative smears contained endocervical and/or metaplastic cells in 50% of the cases, although no atypical or dyskaryotic cells were detectable. The presence or absence of endocervical and/or metaplastic cell types in a cytosmear from the uterine cervix is therefore no indication that the smear has been taken from the correct location.

Carcinoma in Situ↗
PubMed1976

[Transretcat aspiration biopsy in the diagnosis of prostatic cancer (author's transl)].

In almost three years 853 prostatic aspirates obtained from 709 patients were cytologically examined. In 313 patients we also made histological examinations. The cytologic diagnosis could be checked by histology in 288 untreated patients. The cytologic diagnosis of prostatic cancer was confirmed by histology in 65.3% and was false negative in 28.3%. In 6.4% the cytologic material was unsatisfactory for cytologic examination. Considering cytologic findings after repeat aspiration biopsy the accuracy of the cytologic method was 71.7%. The detection rate of prostatic cancer is about 20% higher using both, cytologic and histologic methods, than using cytology or histology, only.

Biopsy, Needle↗