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H J Seib

Publications and source records attributed to H J Seib.

28 records · Page 2Linked to original sources
PubMed1984

[Gastric mucosa heterotopias in the upper gastrointestinal tract].

Heterotopic gastric mucosa does occur in the upper gastrointestinal tract more often than has been thought up to now. Such heterotopic gastric mucosa was systematically looked for in inpatients and outpatients. Islets of heterotopic gastric mucosa were found in 125 patients in the cervical esophagus, in most cases a few centimeters below the esophageal entrance, and in 135 patients such islets of polypoid morphology were found in the duodenal bulbus. Histological analysis done in biopsy specimens taken from the cervical esophagus showed mucosa typical for the gastric corpus in 62 cases, a mixture of glandular tissue from the fundus and mucoid glands in 32 patients, and exclusively mucoid glands in 3 cases. Just superficial mucosa tissue (pits, epithelium) were found in 10 cases, in 14 patients the islets of gastric mucosa were not hit during the biopsy procedure, in 4 cases no biopsy was done. Heterotopic gastric mucosa tissue in the bulbus usually had a diameter of a few millimeters and polypoid morphology; these lesions were located postpylorically in the bulbus and measured more than 5 mm in diameter only in 10 cases. Whereas duodenal heterotopic gastric mucosa probably has no clinical relevance hydrochloric acid producing islets of gastric mucosa in the cervical esophagus may give rise to peptic lesions.

Adult↗
PubMed1983

[Gastric mucosa islands in the cervical esophagus. Their potential pathogenetic significance].

Islands of gastric mucosa were sought in non-selected in- and out-patients undergoing endoscopy. Mucosal islands were found in 40 patients (out of approximately 1000 oesopho-gastroduodenoscopies), mostly a few centimetres below the mouth of the oesophagus. Histology showed "pure" corpus mucosa in 24 cases, a combination of fundus glands (with zymogenic and parietal cells) and mucoid glands were shown in 9 cases; the rest had only mucoid glands (3 cases) or surface elements of gastric mucosa (two cases). In two cases the islands were missed in the biopsy. In one case the demonstration of HCl secretion from a corpus mucosal island could be achieved by local application of congo red via endoscope after stimulation with pentagastrin. The pathogenetic significance of HCl-producing gastric mucosal islands in the cervical oesophagus is due to their ability to induce peptic lesions with subsequent web or membrane formation.

Adenocarcinoma↗
PubMed1982

[Collagenous colitis (author's transl)].

Collagenous colitis, reported four times until now, is characterised histologically by subepithelial tape-like collagen deposits in the rectum and colon. On endoscopy the mucosa appears normal or slightly oedematous. The main symptom is chronic watery diarrhoea without admixture of blood. The cause of diarrhoea is thought to be defective absorption of electrolytes in the colon as a consequence of the pathological collagen deposition. Using endoscopic, histological and electron microscopic findings two further cases of so-called collagenous colitis could be detected. In one of the two female patients chronic watery diarrhoea occurred connected time-wise with the administration of an H2 receptor antagonist. In addition, a clearly increased pancreatic polypeptide (PP) in serum was demonstrated without proof of an endocrinologically active (pancreatic) tumour.

Colitis↗
PubMed1978

[Colonorectal adenoma: relationships among histological structure, dimensions of the polyps, and age distribution].

Among 1258 polyps from the lower gastro-intestinal tract removed by rectoscopy or coloscopy and examined histologically there were 744 adenomas, 72% tubular, 27% papillary and 1% villous. 96.5% of all adenomas were extracted from patients aged over 40 years. Four fifths of the tumours were found in the rectum and sigmoid colon. Only 6% of the tubular adenomas were more than 15 mm in diameter, compared with 32% of papillary and 57% of villous adenomas. The special significance of the adenomas lies in their potential malignancy (adenoma-to-cancer sequence).

Adult↗
PubMed1978

[Adenoma of the colon or rectum: relationship between histological structure, polyp size and site and age distribution (author's transl)].

Among 1258 polyps from the lower gastro-intestinal tract removed by rectoscopy or coloscopy and examined histologically there were 744 adenomas, 72% tubular, 27% papillary and 1% villous. 96.5% of all adenomas were extracted from patients aged over 40 years. Four fifths of the tumours were found in the rectum and sigmoid colon. Only 6% of the tubular adenomas were more than 15 mm in diameter, compared with 32% of papillary and 57% of villous adenomas. The special significance of the adenomas lies in their potential malignancy (adenoma-to-cancer sequence).

Adenoma↗
PubMed1975

[Endoscopic polypectomy of the upper gastro-intestinal tract: results and clinical features (author's transl)].

247 polyps were removed by electroresection through an endoscope (and 240 recovered) in 160 patients, aged 24-81 years. The histological substrate varied widely. Comparison of histological findings in the biopsy specimen with those of the entire polyp after polypectomy gave differing results in 41 of 87 gastric polyps. Complication rate of endoscopic polypectomy was 1.6%: postoperative bleeding occurred in three, which was treated conservatively, while in one patient ligation of a blood vessel by laparotomy became necessary. There were no perforation or lethal complications. Among three patients with hyperplasiogenic gastric polyps a "borderline lesion" was found in two (early carcinoma type I; adenocarcinoma). In 13 other patients with hyperplasiogenic polyps follow-up examination after one year revealed recurrence in three, absence of polyps in eight. In one patient a small gastric carcinoma (about 1 cm in diameter) was discovered four months later. It is possible that patients with hyperplasiogenic polyps are at a higher risk of cancer. Six-monthly endoscopic observation is, therefore, indicated.

Adenocarcinoma↗