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Biomedical subjects

H J Peters

Publications and source records attributed to H J Peters.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Lipid peroxides and antioxidants in the blood of patients with arteriosclerotic circulatory disorders].

Malondialdehyde, vitamin E, glutathione peroxidase and selenium were analysed in the blood of 96 male patients with arteriosclerotic obstructive disease in the region of the leg. Of these 32 patients additionally had manifestations of a coronary or cerebral arteriosclerosis. In the parameters mentioned no significant differences were found between patients with general arteriosclerosis and isolated arteriosclerosis of the leg. Patients with arteriosclerosis and hyperlipoproteinaemia revealed higher values of malondialdehyde than patients without hyperlipoproteinaemia. No correlations were found between malondialdehyde and total cholesterol, triglycerides, vitamin E, glutathione peroxidase as well as selenium.

Arteriosclerosis↗
PubMed1985

[A study of the reliability and validity of the 'Observation Psychogeriatrics' behavior observation scale. An instrument for assessing residual ability and need for care of psychogeriatric patients].

In four Dutch nursing homes the reliability and validity of the behaviour observation scale 'Observation Psychogeriatrics' was investigated. This instrument was meant to assess the remaining capacity and need of care of psychogeriatric patients. It includes nine subscales: for ADL, mobility, specific daily activities, incontinence, time, place and person orientation, social contact, mood and disturbing behaviour, care by the inhabitant for others, care by relatives. The instrument is scored for 159 patients. All nine scales show high internal consistency. Interrater reliability is acceptable. No differences in this respect are found between the four nursing homes. Item reliability is sufficient in general. The scale is well capable of distinguishing psychogeriatric patients at different levels of impairment, especially in the less invalidated patients. The subscales that contribute to this classification, are the Orientation and Contact scale, as well as the scales for Activities of Daily Living and Instrumental Activities of Daily Living.

Activities of Daily Living↗
PubMed1982

[Mezlocillin versus cefuroxime in urinary tract infections. A multicenter clinical study].

In a multicenter randomised clinical comparative study 96 urological patients with established urinary tract infection were treated in 50% with 2 g mezlocillin three times and in 50% with 1.5 g cefuroxime three times. Both antibiotics were shown to be antibacterially active substances with a high bacterial elimination rate. Three days after cessation of treatment the urine was sterile in 79 cases. Follow-up investigations 1-2 weeks later showed that the number of recurrences and reinfections was higher in the cefuroxime group than in the mezlocillin group. This difference is statistically significant so that mezlocillin can be considered the more effective antibiotic. Clinical and urine cytological results correlated with bacteriological results. Side effects were observed rarely, and toxic effects not at all.

Adult↗
PubMed1982

[Trace elements and lipid parameters in arteriosclerotic circulatory disorders by polyene fatty acids].

In 106 patients with peripheral arteriosclerotic obturating disease low values of serum magnesium as well as an increase of the relation of vasoaggressive to vasoprotective lipoproteins could be established. Under a polyene fatty acid diet (40 ml sunflower oil or linseed oil a day) the serum copper values significantly decreased, whereas of the indices of arteriosclerosis only in the linseed oil group of apolipoprotein-B/A-quotient, in the sunflower oil group the triglyceride level decreased statistically significantly. Therefore the favourable influences of physical conditioning as well as of pharmacotherapy on the disturbed lipoprotein metabolism of patients with vascular diseases should additionally be used.

Arteriosclerosis Obliterans↗
PubMed1981

[Clinical experience with fosfomycin in urinary tract infections (author's transl)].

Fosfomycin, an antibiotic from a new class of substances, has a bactericidal action against a broad spectrum of gram-positive and gram-negative organisms. The efficacy of fosfomycin in urinary tract infections was investigated with a dose of 15 g/day. 52 urological patients with obstructive and non-obstructive infections of the urinary tract were accepted for the study. The therapeutic success was convincing: 91% of the pathogens were eliminated from the urine, the urine was free from organisms in 84% of the patients after the treatment. 93% were clinically symptomless. The effects against Pseudomonas was very good: 8 of 9 strains present were eliminated. Unpleasant gastrointestinal side effects occurred which were dependent on the rate of infusion and usually became tolerable at a slower rate.

Anti-Bacterial Agents↗
PubMed1980

[Infusion therapy during transurethral prostatectomy].

In 24 patients undergoing transurethral resection (TUR) of the prostate, sodium, potassium, calcium, magnesium, osmolarity and protein in serum were measured every 15 min. Depending on the composition of the electrolyte solution, there is a sharp fall in serum sodium and osmolarity caused by the leakage of irrigation fluid into the patients circulation. There is also a rise in central venous pressure and a fall of serum protein. There is a correlation between the fall of serum sodium and osmolarity and the rise of central venous pressure. Our results allow the conclusion that a restricted infusion programme with high sodium concentrations can be recommended. Depending on the patients serum protein, preoperative albumin solutions (20%) can be necessary to prevent a dangerous fall of oncotic pressure intraoperatively. The pathophysiology of the TUR syndrome and the importance of an adequate infusion therapy are discussed.

Aged↗
PubMed1979

[Treatment of highly resistant germs by dibekacin in patients with urinary tract infections (author's transl)].

The aminoglycoside dibekacin, developed in Japan and now on the market in Germany, has been tested for its clinical and microbiological effectiveness on 45 patients with highly resistant germs. 41 of the 55 primary sensitive germs could be thus eliminated from the urine, 6 of the 11 being pseudomonas germs. The clinical results of 33 of the 45 patients were very good, only 4 of them were not convincing. The nephrotoxic side effects were noticeably slight. No evidence of damage to the VIIIth brain nerve was observed in these patients. The results were satisfactory considering the selection of problem patients in the test group. Dibekacin can be regarded with gentamicin as a first choice aminoglycoside.

Adult↗
PubMed1979

Effects of adrenergic and cholinergic agents on ureteral functions in dogs.

The effects of the autonomic nervous system on ureteral functions were investigated by application of stimulating and blocking drugs. These effects were differentiated from those due to a change of urine flow by perfusing the renal pelvis with isotonic saline. Peristaltic frequency was readily increased by higher flow volume, but was rarely affected by blockage of alpha-adrenergic and cholinergic receptors. The ureteral pacemaker could be activated by alpha-stimulation and inhibited by beta-stimulation. During perfusion of renal pelvis at a pressure of 12 mm Hg, transport capacity of the ureter could be significantly increased either by alpha-blockade or beta-stimulation. Stimulation of alpha-receptors decreased transport capacity, whereas stimulation of cholinergic receptors remained ineffective. These experiments suggest that responses of sympathetic stimulators and blockers are brought about by their influence on ureter muscle tone. The therapeutic value of these drugs is discussed.

Animals↗
PubMed1979

[Antibiotic therapy after prostatectomy? (author's transl)].

This prospective study shows, that, neither an antibiotic prophylaxis of abacteriuric patients nor postoperative treatment of an asymptomatic urinary tract infection after transurethral prostatectomy have a significant influence on the clinical complications or the microbiologic results. After suprapubic prostatectomy complications in the control group were not significantly more frequent than in the group with antimicrobial prophylaxis. Patients with asymptomatic urinary tract infections before suprapubic prostatectomy had better clinical results, if they were treated with antibiotics as compared to a control group, although the difference control group was not significant. The correlation between consumption of antibiotics and development of resistant in pathogenic organisms forced us to use a more critical approach in the use of antimicrobial prophylaxis and therapy. This study shows clearly, that aseptic operations do not need an antibiotic protection and that faulty of asepsis cannot be corrected by antibiotics.

Anti-Bacterial Agents↗