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Biomedical subjects

H J Peiper

Publications and source records attributed to H J Peiper.

At least 19 recordsLinked to original sources
PubMed1992

[Effect of pancreatic innervation on exocrine secretory performance of the pancreas].

In the present study we examined the influence of extrinsic pancreatic innervation on exocrine pancreatic response to secretin, caerulein, tryptophan and fat, and furthermore the amino acid- and fat-stimulated release of neurotensin and CCK in dogs. Denervation of the pancreas did not alter secretory response to secretin and caerulein, whereas transsection of the extrinsic nerves significantly diminished the protein response to tryptophan and fat. Release of CCK was not altered by pancreatic denervation. However, fat-evoked neurotensin plasma levels were significantly increased after denervation of the pancreas.

Animals↗
PubMed1991

Treatment of iatrogenic common bile duct injury during laparoscopic cholecystectomy through the laparoscopic insertion of a T-tube stent.

Iatrogenic injury to the common bile duct during laparoscopic cholecystectomy has previously necessitated an immediate laparotomy to alleviate bile leakage. In the course of 171 laparoscopic cholecystectomies performed at our hospital, intraoperative common bile duct injuries occurred in 2 patients. Each case was successfully treated using a laparoscopically placed T-tube, thus avoiding the need for a laparotomy. This novel intraoperative procedure successfully treated common bile duct injuries without resulting in postoperative complications.

Adult↗
PubMed1991

Myogenic basis of motility in the pyloric region of human and canine stomachs.

In vitro gastric motility was investigated in 48 human and 16 canine stomachs by measuring the mechanical activity of isolated muscle strips under auxotonic conditions. For a precise regional differentiation, we recorded the mechanical activity of longitudinal and circular strips from fundus, corpus and antrum, as well as from circular preparations of the inner and outer layer of the pyloric sphincter and from the duodenum. The analysis showed that the anatomical division of the stomach into three distinct regions resulted physiologically in different patterns of contraction in vitro for each region. The fundus exhibited purely tonic spontaneous activity and a tonic contraction pattern after application of acetylcholine whereas the activity in the circular antrum was purely phasic. A combination of tonic and phasic contractions was found in the corpus and longitudinal antrum. A major difference in the basic spontaneous activity pattern was evident between man and dog. A gradient of intrinsic frequency in the stomach from proximal to distal was seen in the dog but not in man. A physiologically distinct area exists in the pyloric region of both species adjacent to the antrum and duodenum. The pyloric ring has its own spontaneous activity (minute-rhythm), reacts to the application of acetylcholine with relatively weak contractions and, unique to the dog, was delineated by histamine-induced maximal contractions. The results provide evidence that the pyloric ring is a distinct organ with specific functional characteristics in its cellular-myogenic structure.

Acetylcholine↗
PubMed1979

[Mammography in the diagnosis and treatment of non-puerperal mastitis (author's transl)].

Circumscribed or diffuse non-puerperal mastitis is usually associated with local signs of inflammation. In two-thirds of these cases it is possible to demonstrate the radiological features of mastitis. Mammography is an important diagnostic procedure in the demonstration of acute mastitis and its differentiation from an inflammatory carcinoma; it is also valuable in the control of treatment. The success of intensive antibiotic therapy with recovery of normal appearances in the chest can be observed objectively by mammography. In distinguishing mastitis from an inflammatory carcinoma, radiological evidence of regression under the influence of antibiotics is evidence in favour of mastitis.

Adult↗
PubMed1979

[Endobrachyesophagus and adenocarcinoma of the esophagus].

The columnar epithelium lined esophagus is usually the result of a chronic reflux disease. In the literature one can find more and more references to a malignant transformation of this columnar epithelium. Our own observations of 14 patients with an adenocarcinoma in a columnar-lined esophagus support this suspicion. Because the adenocarcinoma of the esophagus has therapeutic consequences other than a squamous carcinoma of the esophagus, the surgery has to give attention to this malignant transformation of the columnar-lined esophagus.

Adenocarcinoma↗
PubMed1979

[Surgical procedures in inoperable tumours (author's transl)].

This paper deals with the basic surgical principles in inoperable tumours. In case of inoperability the possibilities of palliative surgery should be examined: palliative resection, quantitative tumour reduction, different bypassing procedures in the G.I-tract, amputation, exarticulatoan. It is most decisive to keep the balance between intended effect and operative risk or prognosis of the underlying disease respectively, Additional conservative measures enlarge the indications of palliative surgery.

Bone Neoplasms↗
PubMed1978

[Diagnosis and therapy of primary hyperparathyroidism (author's transl)].

Of 51 patients with primary hyperparathyroidism (2 patients with MEN, Type 1 clinical symptomatology, diagnostic procedures, differential diagnosis, operative strategy and long-term results are being reported. Aside from clinical findings and radiologic signs in our hands determination of the ionized serum calcium fraction, results of chrest bone biopsies and parathormone determinations are best parameters to substantiate the diagnosis of PHPT. Parathormone radioimmunassay determination is very helpful in localizing the adenoma, especially in cases of reoperations. Five patients were seen in acute hypercalcemic crises, in which emergency operations are absolutely indicated. Postoperative hypercalcemia and recurrencies were observed in 3.9%. Successful extirpation of parathyroid adenomas (15% multiple adenomas were found) is the therapy of choice in PHPT, only in cases with hyperplasia subtotal parathyroidectomy is indicated.

Adolescent↗
PubMed1977

[Surgical aspects of secondary hyperparathyroidism (author's transl)].

During long-term dialysis of patients in chronic renal failure disorders of mineral metabolism in the sense of renal osteodystrophy occur increasingly with time. Quite separate from these patients with renal osteopathy (osteomalacia and osteopenia) as a result of dialysis there is a group of patients in whom, despite appropriate dialysate composition, a full-blown picture of renal osteodystrophy due to secondary hyperparathyroidism develops. Subtotal parathyroidectomy will significantly improve them. Experience in 12 patients has demonstrated that, in addition to the clinical signs, biochemical findings and radiological changes, the quantitative evaluation of iliac crest biopsy and determination of parathormone and ionised serum-calcium fraction are decisive as indications for surgery. In these patients subtotal parathyroidectomy gave satisfactory results, but the treatment of renal osteopathy in the sense of osteopenia is often unsatisfactory and the full clinical picture can often be improved only by early renal transplantation.

Adult↗
PubMed1977

[Surgical treatment of the mammary carcinoma according to stage (author's transl)].

Improvement of the results of treatment was achieved only when an increased number of patients were diagnosed in stage I. The prerequisite for limitation of radical surgery is histomorphologic classification of the stages. The central axillary group of lymph nodes appears to be representative of lymph node involvement. Differentiated methods of operations range from local excision to mastectomy in case of precancer. In histologic stage I, modified radical mastectomy; is the treatment of choices; operations with further limitations are recommended only within the scope of controlled studies. In stage II, the classical ablation is still the safest procedure.

Axilla↗
PubMed1977

[The telescope phenomenon. A complication possibility following fundoplication].

On the basis of four cases from our own clinic and three outside cases, we describe a so-called, "telescope phenomenon". This involves a specific complication that may arise after fundoplication. The characteristic of this postoperative complication is the slipping down of the fundus cuff, accompanied by a telescopic pushing upwards of the cardia. Recurrent reflux and occasionally new manifestations of dysphagia are the clinical results of this. This paper describes the diagnostic procedure and therapy of the telescope phenomenon.

Adult↗
PubMed1976

[Clinical results of esophagojejunoplication (author's transl)].

Indications, surgical technique, and clinical results in esophagojejunoplication are shown. In 46 patients the indication for total gastrectomy in 20 cases was a benign disease and in 26 cases cancer of the stomach. An essential feature of this method is the construction of a jejunal cuff, which is drawn around the anastomosis and the terminal esophagus. Particular advantage is the security of the anastomosis; we have observed only three leakages and these were without complications (6.5%). The fatality rate was 8.5%, and the total rate of complications was 26.1%. With 30 surviving patients a postoperative follow-up was carried out, the results of which are shown. Jejunoesophageal reflux occurred in only 7.9% of these patients.

Esophagus↗
PubMed1976

[Cartilaginous tumors of the skeleton].

Chondrogenic tumors of the skeleton are divided into 6 separate groups: 1. chondroblastomas 2. chondromyxoidfibromas, 3. osteochondromas (cartilaginous exostoses), 4. enchondromas, 5. periostal chondromas, and 6. chondrosarcomas. The presentation of the different types of tumors demonstrates the pathogenesis, pathology, clinical findings, treatment, and prognosis. States of tumors before and after operative treatment are illustrated.

Aged↗