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Biomedical subjects

H J Oestern

Publications and source records attributed to H J Oestern.

At least 91 records · Page 5Linked to original sources
PubMed1979

Coagulation and fibrinolysis in multiple trauma after early heparinizing.

In 27 multiple trauma patients receiving standard shock management and intensive care, coagulation and fibrinolysis were investigated after early heparinization. The general coagulation tests did not imply any impaired clotting function. Platelets and factors I, II, and V decreased without induction of hypocoagulability. There was considerable decrease in plasminogen, whereas FDP ranged within normal; thus, a hyperplasminemia can be excluded. Antithrombin III remained within normal range; even in nonsurvivors there was no depletion, although their antithrombin III activity was significantly lower. In comparison to 50 trauma patients - a comparable group with regard to trauma patterns, shock management, and intensive care - there were no significant differences in volume requirements or mortality rate. Whether early heparinization is effective in preventing disseminated intravascular coagulation (DIC) related organ failure remains to be seen.

Adult↗
PubMed1979

Early cardiorespiratory prognostic patterns in multiple trauma patients.

Hemodynamic parameters were monitored for one week ( in greatest detail during the first 24 hours) in 50 severely injured people who had been admitted to the hospital for treatment within one hour after the accident and, as judged by the type of injury, had probably lost more than 1 1/2 liters of blood. The estimations included not only blood pressure, heart rate (HR) and shock index but also the cardiac index (CI), pulmonary arterial pressure (PAP), pulmonary capillary pressure (PCP), and parameters of oxygen transport were determined with the aid of Swan-Ganz catheters, CI, SI, and left ventricular stroke work index (LVSWI) were decreased, PAP, total pulmonary resistance (TPR), and total systemic resistance (TSR), were increased from the very beginning in the nonsurviving group, with a high prediction of vital outcome. The Swan-Ganz catheter is valuable in such cases in obtaining early prognostic evaluation and in controlling therapy - ie, volume replacement, vasodilation, and adrenergic therapy.

Adult↗
PubMed1978

[Creation of reaction-less pseudoarthrosis on the ulna of the dog (author's transl)].

The model situation of so called "avital, avascular" pseudoarthrosis was surgiclly induced in 25 beagle dogs using defectosteotomy and heat-necrotization of both ulna bones. The clinical evolution was examined weekly using roentgengraphy and each 4th week by scintigraphy. According to roentgen pictures three stages can be identified: 1. Reaction of the bone on surgical trauma (until 4th week). 2. Sequestration or asepticosteolysis (until 18th week). 3. Consolidation of the pseudoarthrosis model-situation (after 18th week). Scintigraphy revealed by the continuing so called "avital" pseudoarthrosis an enhanced metabolism activity at the tips of both bone fragments. The cause for these active metabolic processes evoking enhanced activity on both fragment ends during scintigraphy wich is not demonstrable with roentgen device are the pulling, pushing and tensile strengths originating from a connective-tissue-cord existing between them. The results of scintigraphy lead us to use the term "reaction-less pseudoarthrosis" instead of "avascular" or "avital" for this model of pseudoarthrosis.

Animals↗
PubMed1978

[Predictive value of metabolic profiles in multiple trauma].

An increase in the lactate:pyruvate ratio as well as in serum gluocse levels and a decrease in base excess values permit an early prediction of vital outcome in severely traumatized patients. Further laboratory data such as enzymes, bilirubin, and amino-acid concentrations, however, demonstrate significant differences between survivors and nonsurvivros at a later stage, i.e., from the 6th day on.

Acid-Base Equilibrium↗
PubMed1977

[Monitoring of cardio-pulmonary parameters in cases of severe multiple injuries (author's transl)].

Haemodynamic parameters were monitored for one week (in greatest detail during the first 24 hours) in 35 severely injured persons who had been admitted for treatment within one hour after the accident and, as judged by the type of injury, had probably lost more than 1 1/2 litres of blood. The estimations included not only blood pressure, heart rate and shock index; but the cardiac index, pulmonary arterial pressure, pulmonary capillary pressure and parameters of oxygen transport were also determined with the aid of Swan-Ganz catheters. The importance of the data as guide-lines for the correct type of intensive therapy and their prognostic significance are discussed. The evidence provided by the cardiac index, pulmonary arterial and capillary pressure and the parameters of oxygen transport are of particular importance in these cases. A list is added of the values of some haemodynamic factors which should be taken into account in the initial treatment of severely injured persons.

Accidents, Traffic↗
PubMed1977

[Cardiovascular parameters following severe multiple injuries].

Cardiovascular parameters of 35 patients with multiple injuries are monitored over a period of 7 days. Pulmonary artery pressure, pulmonary vascular resistance, intrapulmonary shunts and cardiac output appear to have a significant prognostic value.

Adolescent↗
PubMed1976

[Behavior of reactive shaft pseudarthroses of the canine radius in the electric and electromagnetic fields].

In 27 beagles, 19 radius shaft pseudarthroses and 8 tibia were stimulated either by directly applied alternating current of low frequency and strength, delivered from an implanted battery source, or by a pulsing electromagnetic field inductively coupled to bone. Increase of periosteal callus was only found beneath parallel sling electrodes placed on pseudarthroses parallel to the radius shaft. Stimulation by transverse electrodes implanted into bone produced no significant increase of osteogenesis and bone healing, evaluated by x-rays, scintigrams, and morphometry when compared with contralateral leg controls.

Animals↗