Hormonal control of the glycerol-1-phosphate system by thyroid hormones. Experiments with isolated perfused rat livers.
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Adenine Nucleotides↗
Biomedical subjects
H J Mitzkat
Publications and source records attributed to H J Mitzkat.
[Studies on the effect of insulin on circulation].
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Blood Circulation↗
Ion-exchange chromatography of amino acids in ejaculates of diabetics.
30 amino acids and their derivatives could be found in the ejaculates of humans by ion-exchange chromatography. There were significant differences between diabetics and controls in the levels of threonine, serine, glutamine, glycine, iso-leucine, leucine, tyrosine, phenylalanine, histidine and in 3-methyl-histidine. There was a positive correlation between levels of certain amino acids and the number of pathologically motile spermatozoa, particularly microforms and head alterations. An impaired Krebs cycle function may explain an elevation of amino acid levels as they are utilized mainly by this cycle, which function depends on intact substrate flow from glucose catabolism.
Amino Acids↗
[Effect of pregnancy on carbohydrate and lipid metabolism of the mother--I. Kinetics of various parameters of carbohydrate and lipid metabolism and of various hormones as a function of the length of pregnancy].
Numerous factors influence fetal weight increase and growth. To permit a discussion of biochemical influences on fetal growth, maternal substrates and hormones which influence lipid and carbohydrate metabolism were measured and their relationships were analyzed. In 173 patients the following substrates were measured between the 8th and 40th week of pregnancy: glucose in whole blood and urine, glycerin, triglycerides, total cholesterol, free cholesterol and the hormones HGH, HPRL, HPL, IRI and estriol (E3). A group of nonpregnant and a group of recently delivered women served as controls. The glucose concentration in the whole blood of the mother diminished during pregnancy from 88.3 mg/100 ml to 77.4 mg/100 ml (2 alpha less than 0.05, r = 0.47, n = 77). It was still below the value for the non-pregnant controls post partum (63.6 mg/100 ml as compared to 92.3 mg/100 ml). Glucosuria increased during pregnancy, reaching a maximum in the second trimester. The glycerin concentration was unchanged during pregnancy. As with the post-partial group (0.53 mg/100 ml) the values were lower than those for the non-pregnant control group (1.14 mg/100 ml). The triglyceride concentration increased during pregnancy from 90.3 mg/100 ml to 179.7 mg/100 ml (2 alpha less than 0.00004, r = 0.6, n = 29). In the second and third trimesters (162.9 mg/100 ml, 179.7 mg/100 ml) and post partum (162.3 mg/100 ml) the values were higher than that for the non-pregnant controls (101.5 mg/100 ml). (ABSTRACT TRUNCATED AT 250 WORDS)
Adult↗
[Effect of pregnancy on maternal carbohydrate and lipid metabolism. II: Changes in lipid and carbohydrate metabolism as well as hormonal changes following intravenous glucose administration].
The following parameters of glucose biokinetics in pregnancy, in which the behavior of the glucose in the steady state is described, were investigated mathematically following short-term disturbance of the steady state of the maternal metabolism by intravenous administration of glucose. The glucose assimilation coefficient (KG) is unchanged in pregnancy. However, both during pregnancy and post partum (2.30; 2.20; 2.36; 1.79 [%/min]), the values are higher than in the non-pregnant control group (1.2%/min). Analogously to these findings, the glucose distribution space increases during pregnancy from 13 liters to 16.3 liters, decreasing post partum to 13.4 liters. The easily exchangeable glucose pool, i.e., the quantity available for assimilation in the distribution space, is unchanged during pregnancy; nor is there any change as compared to the non-pregnant and postpartal control groups. Glucose transfer, i.e., the glucose quantity which enters or leaves the pool per unit of time, is increased during pregnancy (0.45; 0.444; 0.47 [g/kg/h]) as compared to the non-pregnant and postpartal controls (0.25; 0.35 [g/kg/h]). The findings above indicate that the maternal glucose metabolism is increased during pregnancy. Owing to the lipolytic effect of HPL, the mother is obliged to meet a portion of her energy requirements from the lipid metabolism, so that there is enough glucose available for the fetus. HPL appears to develop this glucose-saving effect doubly.(ABSTRACT TRUNCATED AT 250 WORDS)
Blood Glucose↗
[Influence of non-diabetic pregnancy on fructosamine and HbA1c concentration].
HbAIc and fructosamine concentrations were measured in the course of 177 nondiabetic pregnancies and compared with the corresponding values of 24 nondiabetic nonpregnant women. In all three trimesters HbAIc and fructosamine were significantly lower than the corresponding values in the nonpregnant women; HbAIc: 1st trimester 4.77 +/- 0.62%, 2nd trimester 4.38 +/- 0.59%, 3rd trimester 4.33 +/- 0.49%, p < 0.01; fructosamine 1st trimester 2.13 +/- 0.17 mmol/l, 2nd trimester 2.02 +/- 0.15 mmol/l, 3rd trimester 1.90 +/- 0.15 mmol/l, p < 0.01; nonpregnant women: HbAIc 5.13 +/- 0.41%, fructosamine 2.53 +/- 0.17 mmol/l. However, if the fructosamine is correlated to the respective total protein concentration a constant value results for the course of pregnancy. The changes in the HbAIc and fructosamine concentrations in pregnancy should be taken into account when treating pregnant diabetics.
Adult↗