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Biomedical subjects

H J Mittmeyer

Publications and source records attributed to H J Mittmeyer.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Determination of the time of dealth after dismemberment. Muscle electrophoretic criteria for estimating the early postmortal period in cadaver parts (author's transl)].

Proteolytic fission products that allow estimation of the time of death can be demonstrated by electrofocussing of cadaver muscles already within the first 5 days postmortem. The fractionation rate, which progressively increases the later the tissue is examined, is based on the number of fractions resulting from protein decomposition. Some fractions appear relatively late, while others occur with increasing frequency and can be used as criteria to determine the time of death. This examination procedure can be used as a method for estimating the time of death in cadaver parts.

Adolescent↗
PubMed1982

Fatal nitrosamine poisoning.

A case is reported in which progressive liver symptoms with rise in bilirubin concentration, hemorrhagic diathesis, and signs of portal hypertension developed three years before death in liver coma. The pathologic and neuropathologic findings are described. The case was clarified after dimethylnitrosamine was demonstrated in food intended for the patient and after it was established that small amounts of nitrosamine could have been repeatedly ingested by the patient over a period of years. Comparable cases of human dimethylnitrosamine poisonings published in the literature are presented. The relatively typical morphologic alterations in the liver are described. Problems involved in the histological interpretation of such liver changes as well as the forensic conclusions to be drawn are discussed.

Adult↗
PubMed1980

[Determination of the myo-albumin content. A possibility to determine the hour of death (author's transl)].

The relatively high stability of albumin in the muscles of a corpse results in an increase of this fraction during the electrophoresis, which is dependent on time. The albumin content gives an inner standard, which can be used for indirect measurements of the proteolysis. Consequently albumin is a suitable parameter to determine post mortem intervals. Investigations carried out during post mortem examinations showed that the increase of the albumin content in skeletal muscles, after storage at 4 degrees C, proves to be roughly linear. From this investigation guidelines or data on the myo-albumin content can be found, which may be used in individual cases to determine the maximum post mortem interval, i.e. the maximum period of time the body lay after the hour of death. Albumin levels below 5.0 rel.% make it almost impossible to range the post mortem interval above one week.

Albumins↗
PubMed1980

[Experimental examinations on forensic determination of time of death by electrofocusing of soluble muscle protein (author's transl)].

Proteolytic changes in the muscles of cadaver are demonstrable by putrefaction experiment with the electrofocusing on polyacrylamide gels. These changes can--within a narrow limit--be used in the determination of time of death at a stage when the early signs of death are not suitable any more. A fraction with a pI-value of 7.2 appears as a proteolytic fission at 30 degrees C not earlier than the second day after death. This fraction can be detected at 20 degrees C from the fifth to the sixth day p.m. At 10 degrees C it will not be detectable until the ninth day p.m. At a pH-range between 6.9 and 7.7, at 30 degrees C and 8 days after death, or at 20 degrees C and 9 days after death, only a relatively stable fraction is detectable with a pI-value between 6.9 and 7.0.

Forensic Medicine↗
PubMed1979

[Investigations to determine the time of death, late post mortem, by means of electrophoresis of inner organs (author's transl)].

In CAF-electrophoresis, extracts of cardiac muscle and of kidney tissue, after storage at 4 degrees C, show a roughly linear increase of the equivalent to the Albumin fraction. This increase depends on the time elapsed and is explained by the relatively high stability of this fraction compared to organ proteins, which appear in the globulin region. Thus, a sort of internal standard exists and can be used as a parameter for the determination of the post mortem period. Hepatic tissue is less suitable for this kind of investigations as the relation of the post mortem period and the values of the relative concentration of the fraction do not show the linearity found in cardiac muscle and kidney tissue. Splenic tissue shows no distinct trend and the findings are of little value. The present investigations were arranged in such a way that taking the order of magnitude for the equivalent of the Albumin fraction as a guideline led to a determination of the maximum post mortem period, i.e., the maximum period of time the body lay after the hour of death. The tables of this paper show the figures for the individual organs.

Death↗