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Biomedical subjects

H J Miller

Publications and source records attributed to H J Miller.

At least 19 recordsLinked to original sources
PubMed1995

The treatment of older adult patients with acute myeloid leukemia by triple infusion chemotherapy.

Adult patients (> or = 56 years old) with acute myeloid leukemia (AML) received induction therapy consisting of daunorubicin (60 mg/m2), etoposide (80 mg/m2), and cytarabine (200 mg/m2) daily for 5 days by continuous i.v. infusion (120 hours). The initial protocol was modified so that patients who were not hypoplastic after the first cycle of chemotherapy received a second cycle of treatment, utilizing 30 mg/m2 of daunorubicin/24 hours for 5 days plus etoposide and cytarabine as used in the first cycle. Two courses of consolidation with etoposide and cytarabine at the same dose and schedule were given. Patients were then maintained on cytarabine monthly. Twelve of 29 previously untreated patients (41%) achieved complete remission (CR). Excluding patients with secondary AML, 48% of all patients (11/23) achieved CR, including 56% > or = 70 years old. The median duration of CR was 41 weeks and median survival of CR patients was 54 weeks. Six of 13 patients (46%) with relapsed AML achieved CR. Toxicity in these older adult patients has been mild. Two patients (8%) had severe mucositis and one had severe (bloody) diarrhea. Most patients developed a mild transient asymptomatic rash. Triple infusion chemotherapy (TIC) may be as effective as other chemotherapy regimens for AML in older adults and has acceptable toxicity.

Acute Disease↗
PubMed1992

POEMS syndrome presenting with cardiomegaly and cardiomyopathy.

A rare association of multisystemic manifestations with plasma cell dyscrasia has been termed POEMS syndrome, which includes polyneuropathy, organomegaly, endocrinopathy. M-protein, and skin changes. From literature reports, organomegaly consists of hepatosplenomegaly and/or lymphadenopathy. We here present a case of POEMS syndrome that had most of the typical features of POEMS, except that organomegaly only involved the heart. The patient's multiple clinical manifestations, including cardiomyopathy, improved with chemotherapy, which is characteristic of POEMS syndrome. However, cardiomegaly or cardiomyopathy have not previously been described with POEMS. The present case suggests that cardiomegaly and cardiomyopathy may be added to the organomegaly in POEMS.

Cardiomegaly↗
PubMed1988

Pneumobelt use among high quadriplegic population.

This study reviews pneumobelt use in an acute rehabilitation facility. All pneumobelt users between 1976 and 1986 were identified. Their age, sex, diagnosis, and time required to adjust to the pneumobelt were studied, as were patterns of use at discharge. Information was collected about use after discharge and about reported advantages and disadvantages. Twenty-three subjects were identified: 21 had spinal cord injuries (SCI), two had had poliomyelitis. The average pneumobelt fitting was three to six months after injury. Twelve SCI patients attained four or more hours of continuous, generally all-day use; another patient achieved this after discharge. Of the remaining eight SCI subjects, all achieved a minimum of two hours of continuous use. The two poliomyelitis patients also achieved all-day use. The survey revealed a high level of satisfaction and continued pneumobelt use after discharge. Major reported advantages were cosmesis, improved speech, independence and mobility, comfort, safety, and health. The pneumobelt is recommended as a leading choice for interim or permanent ventilation of the high quadriplegic population without severe brainstem involvement.

Activities of Daily Living↗
PubMed1987

Pediatric human immunodeficiency virus infection and its cutaneous manifestations.

Acquired immunodeficiency syndrome was first observed in children in 1982. Human immunodeficiency virus (HIV) is now known to be the etiologic agent of this disease complex. Children acquire the viral infection in utero or perinatally, or by receiving contaminated blood products. The cutaneous manifestations include persistent oral thrush, herpes simplex, herpes zoster, molluscum contagiosum, and a variety of fungal and bacterial skin infections. Vasculitis, unusual drug eruptions, and cutaneous manifestations of nutritional deficiencies are also seen.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Non-Hodgkin's lymphoma, HTLV-III/LAV, and HTLV-III/LAV antibody in the wife of a man with transfusion-acquired AIDS.

Non-Hodgkin's lymphoma of the small intestine developed in a 66-year-old woman who was the wife of a man with transfusion-related acquired immune deficiency syndrome (AIDS). Antibody to the human T lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) was present in her serum, and the virus was isolated from her peripheral lymphocytes. The possibility that the non-Hodgkin's lymphoma in this patient was a manifestation of HTLV-III/LAV infection is discussed. This is believed to be the first reported case of lymphoma occurring in a patient with documented HTLV-III/LAV infection outside the male homosexual risk group.

Acquired Immunodeficiency Syndrome↗
PubMed1979

World PCBs map: storage and effects in man and his biologic environment in the 1970s.

PCB residues are found in biota all over the world. A biologic magnification of PCBs has been demonstrated in the food chain: plankton-fish-fish eating birds. A world map of the PCBs residues in biota and some of their biologic effects are given in this study. The biologic effects of PCBs are varied and may generally be explained by the induction or inhibition of the activity of a large number of enzymes, which upsets quantitatively, normal biochemical processes. Harm to reproduction, growth, development, defense systems, tissues, and organs appeared in susceptible organisms as a result of such changes or as a chain reaction to heterostases. The adverse health effects, observed in persons occupationally exposed and in those accidentally poisoned, point to the risk for the general population of an ever-increasing environmental pollution by PCBs. There is need for an integrated approach, consisting of epidemiologic studies on high risk groups in the general population and in persons occupationally exposed, as well as periodic assessment of PCB residues in man, his food, and feed supplies.

Animals↗
PubMed1979

Neurologic involvement in glucagonoma syndrome: response to combination chemotherapy with 5-fluorouracil and streptozotocin.

A 34-year-old man presented with classic glucagonoma syndrome manifested by weight loss, dermatitis, stomatitis, anemia, and mild diabetes mellitus. The diagnosis of glucagonoma was made by light and electron microscopic demonstration of a metastatic alpha cell carcinoma in a liver biopsy specimen. Plasma glucagon concentration was abnormally high. The patient also had symptoms and signs of involvement of the central nervous system. Radionuclide and CAT scans of the brain, negative CSF cytology and myelography excluded the possibility of metastases or other space-occupying lesions. Glucagon was demonstrated in the CSF. We postulate that the neurologic symptoms were due to direct or indirect effect of this hormone on the brain. Following therapy with streptozotocin and 5-fluorouracil, the patient had a subjective and objective clinical and hormonal remission of his disease including amelioration of his neurological impairment.

Adenoma, Islet Cell↗
PubMed1978

Polychlorinated biphenyls induced rat liver adenomas.

Multiple liver adenomas were found in 30 month old female rats which had received for 28 months, 200 ppm polychlorinated biphenyls (Arochlor 1254) in their drinking water. No lung metastases were detected. The examination of fragments of these adenomas under the electron microscope showed group polymorphism of the hyperplastic liver cells. The ultrastructural changes were considered to be as a result of chemical lesions induced by polychlorinated biphenyls and as adaptive morphological responses to the long term exposure to toxic chemical compounds. The group polymorphism was seen in the light of the clonal theory, to be the result of inherited biochemical lesions occurring in cells of hyperplastic liver nodules.

Adenoma↗
PubMed1978

The effects of unsatisfactory working conditions on the epidemiology of unauthorised absenteeism in an old textile factory in Isfahan, Iran.

Comparison of unauthorised absenteeism rates were made between two large textile factories in Isfahan, Iran. The working conditions in the study factory were rather unsatisfactory, unlike the control factory. Comparison showed significantly higher rates for the study factory: the average annual duration per person was 7 days in the study factory versus 2.5 days in the control factory, and lost time percentage was 2.4% in the former versus 0.84% in the control. Inception rate of persons was 0.73 versus 0.48, and point prevalence rates 0.002 versus 0.001, whilst period prevalence rates were 0.016 versus 0.011 for the study and control factories respectively. Examination of the study factory data was made to determine any possible relationship between unauthorised absenteeism rates and age and length of employment. It was found that higher unauthorised rates were found amongst the younger workers, 100% for those age 19 and under, versus 59.6% for those age 50 and over. 9.16% of workers employed for 1--4 years took such leave against 70.14% of those employed for 10 or more years. Only 18.8% of all workers took certified sickness absenteeism and the rate increased with age. It was suggested that worker dissatisfaction toward unsatisfactory working conditions may be expressed in terms of unauthorised absenteeism. In view of the widespread consequences of such absenteeism, it is recommonded that closer attention be paid to improve the quality of working life.

Absenteeism↗
PubMed1977

Analysis of foods for arsenic and selenium by acid digestion, hydride evolution atomic absorption spectrophotometry.

A method based on acid digestion, hydride evolution atomic absorption spectrophotometry for estimating microgram and submicrogram quantities of As and Se in foods was developed and evaluated. Samples up to 3 g dry weight were digested with HNO3-HCIO4-H2SO4. As and Se in aliquots of the digests were reduced with NaBH4 to volatile hydrides, using laboratory-constructed and commercially available generators. As and Se were estimated by transient signal atomic absorbance measurements as the hydrides were decomposed in an Ar-H2-entrained air flame. Recoveries of inorganic As and Se added at levels of 0.1-1.0 microgram/g to a variety of foods ranged from 70 to 125%. Analyses of several standard reference samples indicated the method is capable of recovering native analytes. Detection limits for the determinative step and the method as a whole were as low as 5 and 25 ng, respectively, for both elements.

Arsenic↗
PubMed1977

Acid digestion, hydride evolution atomic absorption spectrophotometric method for determining arsenic and selenium in foods: collaborative study. tpart I.

The hydride evolution atomic absorption spectrophotometric (AAS) method for determining As and Se in foods developed and evaluated by the Food and Drug Administration and Agriculture Canada laboratories was subjected to collaborative study, Twenty-four laboratories provided results for As and 23 provided results for Se levels in 13 different samples consisting of tuna, swordfish, flounder, oyster, liver, flour, skim milk poweder, spinach, kale, and apple containing natural levels of As and Se in the ranges 0-15,000 and 0-4000 ng/g, respectively. Reference materials formed a substantial segment of samples, and a number of other laboratories using fluorometry, colorimetry, neutron activation, spark source mass spectrometry, and graphite furnace AAS provided confirmative reference values for the remaining samples. A variety of hydride generation instruments were used, ranging from commercially available devices to semiautomated and fully automated custom-made instruments. Although the accuracy of the method was fairly good, between-laboratory and between-determination (hydride evolution AAS measurement) precisions were not favorable. The main advantage of the hydride AAS method is the rapidity of the determinative step.

Arsenic↗
PubMed1975

Busulfan toxicity.

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Adrenal Insufficiency↗