Biomedical subjects

H J Lisch

Publications and source records attributed to H J Lisch.

At least 55 records · Page 3Linked to original sources

PubMed1976

[Effect of long-term treatment with synthetic oestrogens on plasma lipids and arterial vessels in male rabbits (author's transl)].

The effects of long-term treatment with synthetic oestrogens (Retalon retard, Sanabo Ltd., Wien, 5 mg/kg i.m. at weekly intervals) were investigated in 12 male rabbits and compared with the data obtained in 9 saline-treated control animals. After 6 months of treatment the oestrogen group showed significantly higher plasma phospholipid (p less than 0.005) and cholesterol (p less than 0.01) concentrations than the control group. However, histological examination of various important arterial vessels (the aorta and the coronary, cerebral, limb and renal arteries) revealed no pathological changes indicative of premature atherosclerosis in either the oestrogen group or in the control group. It is concluded that long-term treatment with synthetic oestrogens does not result in a higher incidence of atherosclerosis in rabbits.

Animals↗

PubMed1976

[Insulin and adipose tissue (author's transl)].

The effect of insulin and glucose on lipolysis, on the re-esterification rate of free fatty acids and on glucose oxidation was investigated in isolated fat cells of the greater omentum. Insulin alone inhibited increased lipolysis only, but had no effect on normal basal lipolysis. The insulin effect on lipolysis was not altered by glucose. The re-esterification rate of free fatty acids was stimulated by glucose in a dose-dependent way. Insulin had no effect on the re-esterification rate of free fatty acids in the presence or absence of glucose. Basal glucose oxidation was slightly, but significantly increased by insulin. It is concluded that the prinicipal action of insulin in human adipose tissue is the inhibition of increased lipolysis, whereas glucose metabolism remains largely unaffected by insulin.

Adipose Tissue↗

PubMed1976

[Lipolysis in human adipose tissue (author's transl)].

Lipolytic activity was measured under different conditions in isolated fat cells and homogenates of human adipose tissue of the greater omentum. It was demonstrated that lipolysis took place in isolated fat cells at an optimum pH of 7.4 and was markedly stimulated by noradrenaline, but not by blood serum. By contrast lipolysis was significantly stimulated by blood serum, but not by noradrenaline, in homogenates of adipose tissue. Serum-stimulated lipolysis exhibited optimum activity at pH 8 and was inhibited by 1M sodium chloride. It is concluded that lipolytic activity in isolated fat cells can mainly be ascribed to the action of hormone-sensitive lipase, whereas lipolysis in homogenates of adipose tissue in the presence of serum is mostly regulated by lipoprotein lipase.

Adipose Tissue↗

PubMed1974