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Biomedical subjects

H J Koch

Publications and source records attributed to H J Koch.

At least 19 recordsLinked to original sources
PubMed1990

[Local immune responses in gonorrheal cervicitis].

Endocervical biopsies taken from 74 female patients with gonorrhea and 18 healthy women were investigated by means of fluorescence with regard to the evidence of IgA, IgG, IgM, C3, C4, fibrinogen, lysozyme, and N. gonorrhoeae. Whereas C3, C4, fibrinogen, lysozyme, and N. gonorrhoeae were especially observed in the early stages of the disease, the amount of plasma cells producing IgA and IgG were found increased in the advanced stages of gonorrhea.

Adult↗
PubMed1990

[Detection of IgA in diseased skin and serum of patients with psoriasis vulgaris].

Origin and function of IgA in the psoriatic skin are unknown. Including a monoclonal antibody against the secretory component (SC) of the secretory IgA (SIga), we have tried to characterize the IgA in psoriasis. With help of a polyclonal antiserum we found depots of IgA in the skin in 69% of all investigated patients. There was a correlation between the degree of akanthosis and the amount of intraepidermal IgA. In the serum of the psoriasis total IgA was significant increased, but never we found SC-bound SIgA in the skin or elevated levels in serum of patients.

Adult↗
PubMed1989

[Psoriasis vulgaris--unchanged endothelial reactivity with histochemical markers].

Frozen sections from psoriatic lesions were investigated regarding their reactivity with endothelial markers (UEA I, EEA I, LTA, Con A, factor VIII-related antigen). We compared the findings obtained with those of both uninvolved psoriatic skin and normal skin. Although all lectins showed altered epidermal binding in comparison to the controls, the endothelial lectin binding as well as the expression of factor VIII-related antigen were the same in both psoriatric lesions and controls. Our findings argue for (1) intact dimorphic genetic control of ABH expression in both epidermal and endothelial cells, (2) altered epidermal differentiation of lesional psoriatric skin, and (3) secondary vascular alterations.

Biomarkers↗
PubMed1989

[Direct immunofluorescence study of active psoriasis lesions].

Active psoriatic lesions have been investigated by direct immunofluorescence technique with polyclonal antisera to immunoglobulins and C3. We observed a cytoplasmic fluorescence of suprapapillary, suprabasally keratinocytes with tight topographical relationship to the parakeratotic horny layer. The intracellular deposits were IgA (in 60% of cases), IgG (53%), IgM (47%), C3 (30%). IgE und IgD have not been detected. The relationship of cytoplasmic protein deposition in vivo to parakeratosis is discussed briefly.

Autoantibodies↗
PubMed1988

[Detection of antibodies to Neisseria gonorrhoeae in cervicovaginal secretion and in serum].

In 33 female patients suffering from gonorrhoea, we searched for specific antibodies (IgA, IgG, IgM) directed against gonococci by means of the indirect immunofluorescence technique. This investigation was performed both before and after specific treatment. In comparison to 17 healthy women, we found increased rates of IgA and IgG antibodies in the secretion of our patients, the IgA rate being slightly higher than the IgG count; IgM was not detectable at all. In the serum, IgG antibodies clearly dominated over IgA and IgM. After successful treatment, IgA antibodies showed a more rapid reduction than IgG in both secretion and serum.

Adult↗
PubMed1988

[Increased phagocytosis of N. gonorrhoeae by human granulocytes in vitro after addition of cervicovaginal secretions or serum from patients with gonorrhoea].

Factors promoting the phagocytosis of N. gonorrhoeae were estimated in the cervico-vaginal secretions and in serum of 129 female patients suffering from gonorrhea. 76 healthy women served for comparison. The increase of granulocyte-phagocytosis in vitro, mediated by secretions and serum from patients and in part also from patients after therapy was stronger than that of healthy women. Although the absolute amount of phagocytosis mediated by serum was higher, there was clearly a stronger increase of secretion-mediated phagocytosis, while using material from patients. After inactivation of serum and secretions by heating, a decrease of phagocytosis could be observed in patients and healthy women, too. The greater calculated differences in patients than in healthy persons are distinct signs for stronger induction of thermolabile factors in the patients.

Cervix Uteri↗
PubMed1986

The measurement of body image disturbances in anorexia nervosa. Experimental comparison of different methods.

Body image disturbances in anorexia nervosa patients have been assessed in an experimental study which dealt with the following issues: Three different procedures for the assessment of body image disturbances were compared in a discriminant function analysis: a Video Monitor Procedure, the Movable Caliper Procedure and the Image Marking Procedure. The Image Marking Procedure showed the best discrimination between groups. Anorexia nervosa patients showed a statistically significant overestimation as compared to the control group in the variables 'waist', 'upper thigh' and the compound measure 'soft body parts', while they did not overestimate control variables (Kruskal-Wallis-Rank-Analysis of Variance). A standard liquid meal of 240 Kal. had no statistically significant influence on the estimation of body width, irrespective of the amount of calories consumed and instruction given. Possibilities and limitations of various measurement procedures are discussed.

Acute Disease↗