[Operative hearing improvement in obliterated tympanum and irreversibly blocked eustachian tube. 1].
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Biomedical subjects
H J Gerhardt
Publications and source records attributed to H J Gerhardt.
[Quantitative findings on the morphology of the vestibular nerve in Menière's disease].
In vestibular nerves of patients without any inner ear disease and from patients who suffered from Menière's disease, the number, diameter, and density of nerve fibres were determined in the whole nerve as well as in the different parts (pars superior and pars inferior). As regards normal values, the number of fibres in the whole nerve ranged between 17 097 and 23 088 (age group: 40-54 years). In nerves from Menière patients the number of nerve fibres was diminished: in cases of 5-7 years of duration by about 13-37%; in cases of 15-21 years of duration, by about 73%. The persisting nerve fibres showed an increase in the number of thinner fibres, but occasionally also some very thick ones with giant myelin sheaths could be observed. The number and density of nerve fibres were appreciably diminished in the nervus ampullaris anterior, posterior, and nervus saccularis. The degenerative changes in Menière's disease were more pronounced in the phylogenetically younger pars inferior with progression in the later stages of the disease.
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[Light and electron microscopic study of the vestibular nerve and Scarpa's ganglion in Ménière's disease].
Degenerative changes in both the nervus vestibularis and in Scarpa's ganglion depending on the duration of Meniére's disease are visualized by light and electron microscopy. The specimens were obtained by transtemporal neurectomy in patients with Meniére's disease and were fixed quickly. On the thick nerve fibres (pars superior) a splintering of the myelin lamellae, an increase in the nerve fibre diameter and the formation of myelin globes were found. On the thin nerve fibres (pars inferior) protrusion and introversion of whole parts of the myelin sheath had been observed. In the later stages of the disease, losses of axons and decay of myelin sheath were evident. In Scarpa's ganglion, different stages of ganglion cell degeneration were found. The degenerative morphological changes in the nerve and ganglion were more obvious in later stages of the disease.
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