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Biomedical subjects

H J Dobbs

Publications and source records attributed to H J Dobbs.

26 records · Page 2Linked to original sources
PubMed1985

Low-dose 131I in treatment of Graves' disease.

One hundred and sixty-four patients with Graves' disease were treated with low-dose radioiodine (2 mCi), with a mean follow up of 4 1/2 years. At this time 74 (45%) were euthyroid having had a single dose, with a total of 131 (80%) being controlled with one or more doses. Three (2%) were still toxic but their mean follow up was only 3 years. Thirty (18%) were rendered hypothyroid, two-thirds of these after a single dose of 2 mCi 131I. The one-year incidence of hypothyroidism was 6%, with an incidence at 6 years of 20%. Previous surgery, medical treatment and thyroid antibody status appeared to have no influence on the outcome.

Adult↗
PubMed1985

The role of CT in the staging and radiotherapy planning of prostatic tumours.

Fifty patients with proven carcinoma of the prostate have been evaluated with CT. The CT studies were carried out for staging and radiotherapy planning and the findings compared with rectal examination and lymphography. CT provided useful additional information to that obtained by rectal examination in 40% of patients and these findings had important implications for radiotherapy planning. There was good correlation between CT and lymphography in the assessment of pelvic lymph node involvement.

Aged↗
PubMed1984

The respective roles of the simulator and computed tomography in radiotherapy planning: a review.

The advent of computed tomography (CT) scanners and the development of a CT facility on treatment simulators has provided an array of expensive equipment for use in radiotherapy treatment planning. The object of this paper is to review the requirements necessary for accurate radiotherapy planning and to present guidelines regarding the system which appears best suited to plan individual tumour sites, based on our experience of CT scanning and related techniques over the past 6 years.

Brain Neoplasms↗
PubMed1983

The use of CT in radiotherapy treatment planning.

A prospective study is reported comparing conventional localisation with computed tomography (CT) localisation of tumours for radiotherapy treatment planning. One hundred and five out of 320 (33%) patients had an alteration in treatment plan and details are given according to the tumour site. CT planning enables more accurate localisation of both tumour and normal organs in addition to providing an accurate body contour and inhomogeneity corrections. Implications for integration of CT into radiotherapy planning practice are discussed and the impact of CT on treatment policy evaluated.

Abdominal Neoplasms↗
PubMed1983

The treatment of metastatic germ-cell testicular tumours with bleomycin, etoposide and cis-platin (BEP).

Between July 1979 and December 1981, 43 patients with metastatic germ-cell tumours (36 testicular non-seminomas and 7 testicular seminomas) were treated with 2-6 cycles of bleomycin, etoposide and cis-platin (BEP). Forty (93%) are alive, 37 (86%) with no evidence of disease. Of 36 men with testicular non-seminoma 30 (83.3%) are alive and disease-free at 8-38 months (median 17.0 months). In the latter group 25/28 (89.3%) who had had no prior irradiation are alive and disease-free. Fourteen non-seminoma patients had small volume metastases and 13 are in complete remission, as are 12/14 patients with bulky disease. All 7 patients with advanced seminoma are alive and disease-free. It is concluded that BEP is a well tolerated and effective first line treatment for patients with metastatic germ-cell tumours.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1983

Thyroid damage--after treatment for Hodgkin's disease.

Advances in the treatment of Hodgkin's disease in the last 20 years have led to a marked improvement in survival but also to a significant increase in treatment-related complications. Infertility, growth disturbance and carcinogenesis have attracted well deserved attention. This paper reviews the thyroid complications of treatment since these are important to patient and clinician and if missed may result in unnecessary morbidity.

Graves Disease↗
PubMed1981

Total-body irradiation in advanced non-Hodgkin's lymphoma.

Thirty-seven patients with advanced non-Hodgkin's lymphoma who were treated by total-body irradiation (TBI) at the Royal Marsden Hospital are reviewed. Twenty-four patients had received no previous therapy; 13 patients were in relapse. The overall response rate was 73% for nodular lymphomas and 80% for those with diffuse disease. THe duration of complete response ranged from two to 41 months (median 12 months). Subsequent chemotherapy was given successfully except in patients with prolonged thrombocytopenia which appeared to be related to an initially involved bone marrow. Hemibody irradiation (HBI) was the least myelosuppressive form of TBI and is now being used in complete remission following chemotherapy.

Adult↗