Biomedical subjects
Publications and source records attributed to H J Buchsbaum.
The healing of a midfibular fracture was studied in mature rats. The strength of the healing fracture was determined by a constant speed-driven tensiometer which measured the force required to separate the healing callus. The breaking strength of the healing experimental fracture was ascertained in control, estrogen-treated, and oophorectomized animals. The fracture strength was not significantly different in any of these groups.
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One hundred and thirty-three subarachnoid phenol blocks were performed in 90 patients with intractable pain secondary to gynecologic cancer at the University of Iowa Hospitals in the period 1961 to 1975. Excellent to moderate pain relief was obtained in 77% of 117 evaluable blocks. Fifty-two percent of the blocks gave relief of over 1 months' duration and 27% over 2 months. Fourteen patients had a second contralateral block and 11 obtained 4 to 8 weeks' relief. Complications were temporary and occurred in 71% of the blocks, the most common being urinary and rectal incontinence. Subarachnoid phenol block is an effective method for relief of intractable pain; its use in gyneclogic oncology is discussed.
Fifty-five patients treated for cervical carcinoma developed bony metastases between January 1, 1961 and December 31, 1973. Roentgenograms were diagnostic in all but 2 of the patients. In 15 patients, a combination of radioactive scans and roentgenograms was used to establish the diagnosis. The most common mechanism of bony involvement from carcinoma of the cervix was extension of the neoplasm from para-aortic nodes, with involvement of the adjacent vertebral bodies. The earliest metastases were discovered at the time of the primary diagnosis. Thirteen years was the longest interval from the primary diagnosis until the discovery of bony metastases. Sixty-nine percent of the patients were diagnosed within 30 months. Ninety-six percent of the patients died within 18 months. Seventy-six percent of the patients received some form of therapy for their metastases. Thirty-six of these patients were treated with radiation therapy. Four of these patients received complete relief of symptoms, 24 some relief, and 8 patients received no relief.
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In the management of pelvic malignancies treated by radiation the standard ileal conduit is subject to many hazards related to the use of damaged tissues. The transverse colon affords the use of a short isolated segment of non-irradiated bowel as a urinary conduit. The ureters can be dissected well above the field of pelvic irradiation. Eight patients with bladder or cervical carcinoma treated with high doses of external radiotherapy are presented to demonstrate the usefulness of the transverse colon in supravesical urinary diversions.
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The literature on gunshot wounds of the gravid uterus is reviewed, and three new cases reported. Clinical management is discussed, with emphasis on the condition of the abdominal wall and other connective tissue during pregnancy, the contraindications for paracentesis, the changes during pregnancy in blood volume, central venous pressure, white blood count, and GI and GU tracts, and indications for celiotomy or cesarean section.
The embryology and clinical implications of Meckel's diverticulum, the most common gastrointestinal anomaly, are presented from the viewpoint of the obstetrician-gynecologist. The complications and clinical management are discussed.
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The hospital records of 24 patients over 75 years of age who had 25 surgical procedures in treatment for invasive gynecologic cancer were viewed. The patients were matched with control intraoperative and postoperative complications compared. The incidence of wound complications was higher in the elderly patients, while the other complications were lower. Age should not be an absolute contraindication to surgery for gynecologic malignancy if the prospects of cure are good.
Disturbances in the blood coagulation mechanism are seen by the obstetrician and gynecologist as rare complications of abruptio placentae, retained dead fetus syndrome, amniotic fluid embolism, toxemia, saline amnioinfusion, and septic abortion. Two cases of disseminated intravascular coagulation complicating gynecologic malignancy are presented. Laboratory studies showed thrombocytopenia, hypofibrinogenemia, and increased fibrin degradation products. Derangements of hemostasis in patients with malignancy are discussed from a clinical viewpoint.
The role of radioisotopes in the treatment of ovarian carcinoma is discussed. The University of Iowa experience with prophylactic treatment of stage Ia ovarian cancer with radiogold is presented. Cumulative survival in 56 patients with epithelial cancers was 94.3%. In a prospective study, we compare the use of radiogold and total abdominal irradiation in the treatment of stage Ia ovarian carcinoma.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.