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Biomedical subjects

H J Bodansky

Publications and source records attributed to H J Bodansky.

66 records · Page 4Linked to original sources
PubMed1982

Increased plasma renin activity in type 1 diabetes with microvascular disease.

Plasma renin activity was measured in thirty-one subjects with Type 1 diabetes and proliferative retinopathy, and in seventeen matched diabetic subjects without evidence of any complications of their disease. The two groups were comparable for age, sex, smoking habits and duration of diabetes. Systolic and diastolic blood pressures were significantly higher in the patients with retinopathy (P less than 0.025 and P-0.05 respectively) and HbA1 was greater (P less tha 0.005) than in the patients without complications. Plasma renin activity, both lying and standing, was higher in the patients with retinopathy than in the uncomplicated group (P less than 0.05 for each). There were no correlations between plasma renin activity and mean blood pressure, HbA1 or fasting blood glucose. These findings raise the possibility that the renin-angiotensin system might be implicated in the pathogenesis of diabetic microvascular.

Adult↗
PubMed1982

Diabetic retinopathy and its relation to type of diabetes: review of a retinal clinic population.

A detailed survey was performed of 100 consecutive diabetic patients with severe retinopathy referred to a retinal clinic. They were classified as having either type 1 (insulin-dependent) or type 2 (noninsulin-dependent) diabetes. There were significant associations between an initial diagnosis of maculopathy. There was a significant association between male sex and proliferative retinopathy. Referral patterns to this clinic and the medical supervision of the patients are discussed.

Adult↗
PubMed1982

Genetic and immunologic factors in microvascular disease in type I insulin-dependent diabetes.

A detailed study of 133 subjects with insulin-dependent (type I) diabetes with severe microvascular disease has failed to substantiate the hypothesis that HLA factors influence the predisposition to this type of complication. A significant association between proliferative retinopathy and raised levels of circulating immune complexes was found. The distribution of insulin-binding levels in serum was similar to that in patients without complications. There was no correlation between insulin binding and the presence of immune complexes and no evidence was found that these complexes contained anti-insulin, anti-nuclear, or organ-specific antibodies. The distribution of insulin-binding levels in these subjects with diabetes of long duration was similar to that observed in 270 subjects with juvenile-onset short-duration type I diabetes. When the data were combined, significant associations between HLA-B8 and low/absent insulin binding levels were observed. HLA-BW62 was not associated with either high or low insulin-binding capacity. It is concluded that HLA genetic factors, insulin-binding capacity, and autoimmunity are unrelated to the pathogenesis of microvascular disease. Raised levels of circulating immune complexes may well be secondary to widespread tissue damage in diabetes of long duration.

Adult↗
PubMed1982

Long term improvement in insulin response with gliclazide treatment.

Blood glucose, plasma insulin and C-peptide concentrations were measured in response to a standard meal in eight Type 2 (non-insulin dependent) diabetic patients before and after treatment with gliclazide for 33 +/- 9 months. Compared with the pre-treatment values, blood glucose levels remained significantly lower (p less than 0.00001), while plasma insulin and C-peptide concentrations remained significantly higher (p less than 0.00001 and p less than 0.001 respectively) throughout the treatment period. In contrast to previous studies, these findings demonstrate that prolonged sulphonylurea treatment produces continued enhancement of B cell secretion.

Adult↗
PubMed1981

Acetylator phenotypes and type I (insulin-dependent) diabetics with microvascular disease.

We have investigated the acetylator dimorphism in 55 type I (insulin-dependent) diabetics. The frequency of the fast phenotype (49%) was higher than in the general Northern European population (37%). Although this difference was not significant (chi squared = 2.64, P = 0.1) the combination of our data with data from two other studies produced a significant positive association between the fast acetylator phenotype and type I diabetes (P = 0.00013, relative risk = 2.0). These findings lend support to the concept that more than one genetic locus may be involved in the susceptibility to type I diabetes. No association was found between acetylator phenotypes and diabetic complications.

Diabetes Mellitus, Type 1↗
PubMed1981

Plasma C-peptide in long-standing type 1 diabetics with and without microvascular disease.

Plasma C-peptide levels were measured both in the fasting state and in response to a standard breakfast in 37 Type 1 (insulin dependent) diabetics with severe proliferative retinopathy, 20 Type 1 diabetics without complications and 13 non-diabetic subjects. The two diabetic groups were matched for age and duration of diabetes. Seventeen out of 37 subjects with diabetic complications had detectable C-peptide compared with three out of 20 in the group without complications (p less than 0.05). There was a significant correlation between fasting C-peptide levels when present and the increment in C-peptide (r = 0.89, p less than 0.0001). There was no correlation between C-peptide levels and the fasting blood glucose or HbA1. No evidence was found to support the hypothesis that in long-term diabetics, sufficient beta-cell function may persist which measurably influences diabetic control and prevents the development of microvascular complications.

Adult↗
PubMedDate not supplied

The relationship of the renin-angiotensin system in type I diabetes to microvascular disease.

There are conflicting data on the relationship between diabetes mellitus and its complications and the renin-angiotensin-aldosterone system. Much of this relates to the patient populations studied (those with types I and II diabetes) and the definitions of diabetic complications. We studied plasma renin activity and concentration, and factors involved in their control (age, blood pressure, and sodium excretion) in 40 healthy subjects (group 1), 18 patients with type I diabetes without complications (group 2), and 31 with type I diabetes with proliferative retinopathy (group 3). The groups were well matched for age, sex, and body weight, but patients in group 3 had higher supine blood pressures than those in the other two groups (133/78 mm Hg vs 118/74 group 1, p less than 0.01; 120/72 group 2, p less than 0.05). Median plasma renin activity, both supine and erect, was 60 to 120% higher in group 3 than in group 1 (p less than 0.001) and 55 to 75% higher than in group 2 (p less than 0.05). There was good evidence of a fall in both values with increasing age in all three groups. Patients in groups 1 and 2 showed evidence of inverse relationships of both blood pressure and urinary sodium with plasma renin activity/concentration ratio, but these relationships were not apparent in subjects in group 3. There is thus evidence of impaired regulation of renin secretion in persons with type I diabetes with proliferative retinopathy, the commonest form of microvascular disease. This may contribute to the relative hypertension and progression of complications.

Adult↗
PubMedDate not supplied

Risk factors associated with severe proliferative retinopathy in insulin-dependent diabetes mellitus.

The natural history of disease and suspected risk factors for bad prognosis were investigated in 40 subjects with insulin-dependent diabetes mellitus who had severe retinopathy and in 22 patients with a similar duration of diabetes without evidence of complications. The retinopathy group showed a marked excess of men (ratio 2:1). Examination of the data in the literature also showed a striking excess of men, 61% (P less than 0.001) in patients with insulin-dependent diabetes and severe microvascular disease. In addition, proliferative retinopathy was found to have significant associations with current poor diabetic control, hypertension, and previous treatment with once-daily insulin regimens, particularly with protamine zinc insulin.

Adult↗