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Biomedical subjects

H J Bochnik

Publications and source records attributed to H J Bochnik.

31 records · Page 2Linked to original sources
PubMed1979

[Phenomenology and psychopathology of agitation states].

States of agitation are frequent psychiatric emergency cases, which stem from very different biological, psychic and social constellations. Very often it is a question of a slipping expression of strong affects like fear, anger, pain and of excessive, reactive performances like flight, defence etc., which are built on top of the affects. Inner restlessness, which rises from unrestrained and disfigured drives, and the accompanying autonomic reactions of the affects promote the beginning of these states of agitation; whereas sensible expectations and clearly aimed absorptions of the drive do reduce the disposition to becoming agitated.

Drive↗
PubMed1978

[On improved prophylaxis of endogenous-phasic psychoses. Influence of L-aspartate on lithium transport (author's transl)].

The influence of aspartate on lithium transport was studied with humna red blood cells (rbc) in vitro and after i.p. injection of Li-DL-asp or LiCl in different tissues of the rat. After administration of Li-asp the lithium concentrations in brain and rbc of the rats increased more slowly compared to rat treated 3 to 6 days with Li-asp were more than two times higher than those of rats treated with LiCl. After daily injection of the two salts, lithium levels in the brains of rats teated with LiCl. Results of in vitro experiments with human rbc indicate that the effect of aspartate on lithium transport is specific for L-aspartate. In addition a similar but smaller effect has been observed with l-glutamate.

Amino Acids↗
PubMed1977

Substrate-typic changes of platelet monoamine oxidase activity in sub-types of schizophrenia.

Monoamine oxidase (MAO) activity has been measured in the platelets of controls (n = 42) and schizophrenic patients (n = 49) of three subtypes, using beta-phenylethylamine, p-tyramine, and tryptamine as substrates. Characteristic differences of MAO activity were observed between platelets of patients and controls; the differences were substrate-typic: decreased enzyme activity was found with all three substrates in platelets of the parnaoid subtype. With tryptamine, MAO activity was decreased in the platelets of all three sub-types of schizophrenia. With p-tyramine, MAO was low in patients with affective psychoses and paranoid schizophrenia. The value of MAO activity measurements as a means for distinguishing sub-types of schizophrenic disorders is improved by using two substrates; tryptamine and p-tyramine. Possible mechanisms of the substrate-typic changes of platelet MAO activity in schizophrenia are discussed.

Adult↗
PubMed1976

A routine assay procedure for monoamine oxidase and its application to human blood platelets.

In the radiometric assay procedure for monoamine oxidase separation of the reaction products by ion-exchange column chromatography was optimized. A device was constructed that allowed the separation of 48 samples at the same time. This device can be applied for a great variety of analytical methods. With a 0.1 mM substrate concentration in the incubation mixture, reaction products could be determined with a reproducibility of 2-5%, where the standard deviation depends on the substrate. Using beta-phenylethylamine as substrate 20 mug of platelet protein was sufficient for monoamine oxidase activity determinations. The dependence of human blood platelet monoamine oxidase on age and sex were studied using the method.

Adolescent↗
PubMed1976

[On improved prophylaxis of endogenous-phasic psychoses: aspects of parallel determination of lithium in serum and erythrocytes (author's transl)].

In 30% of the psychiatric patients investigated the lithium concentration in erythrocytes (RBC-lithium) is a more reliable indicator for the evaluation of the clinical response and the risk of toxicity. After lithium administration the lithium RBC levels increased within the first three weeks. Lithium RBC/plasma ratios are not different between unipolar, bipolar and schizo-affective psychoses. It was found that low lithium RBC/plasma ratios correspond with low monoamine oxidase (MAO) activity in platelets.

Affective Symptoms↗
PubMedDate not supplied

[Process and phasic psychoses according to ICD-9 classification].

101 in-patients were diagnosed according to the ICD-9 and the Frankfurt (FC) classifications. The latter classification used the glossary of the AMDP system, and the Andreasen scale (SANS). 94% of the FC process psychoses were diagnosed as schizophrenia according to ICD-9 and 78% of the atypical phasic psychoses (FC) as schizoaffective schizophrenia (ICD-9). On the other hand, only 55% of the ICD-9 schozophrenias could be classified as a FC process psychosis. The results confirm the assumption that the ICD-9 classification is not helpful in distinguishing phasic from non-phasic psychoses. Advantages of a classification based on phasic or non-phasic course are mentioned. Finally it is emphasized that the operationalization of concepts (either classic or new), the polydiagnostic, and the use of international glossaries (like the AMDP system) are an unavoidable step for the development and extension of the psychiatric research in Latin America.

Adolescent↗