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Biomedical subjects

H J Anderson

Publications and source records attributed to H J Anderson.

At least 73 records · Page 4Linked to original sources
PubMed1992

Reform debate must address appropriate capital incentives.

In the broad debate over health care reform, the issue of how to regulate hospital capital spending is being touched on lightly. Many options exist--from incentives built into a national payment mechanism to market-driven plans.

Capital Expenditures↗
PubMed1992

New surgical technologies reshape hospital strategies.

New technologies are rapidly transforming hospital surgery, shifting a majority of procedures to outpatient settings and cutting stays for inpatients. This shift is forcing hospitals to re-evaluate physician privileging, surgical staffing and scheduling, facility planning and strategic planning. Meanwhile, the Health Care Financing Administration's efforts to reform Medicare's payment system for outpatient surgery and other ambulatory procedures is on a slower track.

Ambulatory Surgical Procedures↗
PubMed1992

Hospitals seek new ways to integrate health care.

In the 1980s, many CEOs and senior management teams operated in isolation. A reimbursement system designed to encourage competition led to a "survival-of-the-fittest" mentality that prompted many managers to develop "competitive strategies" and look for "niche opportunities." In many cases, the end result was a fragmented delivery system with--in some instances--gaping holes. Now, CEOs are looking for ways to put the pieces back together. The first part of this cover story examines the issues surrounding the rapidly emerging trend of regional delivery systems; the second part, which begins below, looks at four case histories of different types of integrated systems at various stages in their development.

American Hospital Association↗
PubMed1992

Ambulatory care directors help hospitals gear up for growth.

The continuing shift toward outpatient care is spurring many hospitals to rethink their administrative structures. Hospitals interested in improving the coordination of their outpatient services are appointing ambulatory care directors and involving them in strategic planning for that area.

Ambulatory Care↗
PubMed1992

Characterization of cultured human nesidioblasts and their associated macromolecules: cross-reactivity with a cloned rat pancreatic beta-cell line.

Near-total pancreatectomy in a neonate presenting with persistent hypoglycemia offered an unusual opportunity to grow preparations enriched in beta-cells. Morphology, chromosomal analysis, and immunohistochemistry were used to characterize a subculture (Nesi B) that remained stable through passage 11. Insulin secretion of Nesi B was constitutive at 38-74 nU/microliters of medium/24 h, increasing modestly in the presence of isobutylmethylxanthine, an inhibitor of cyclic AMP phosphodiesterase. Endocrine cells, exclusive of those in islet regions, were widely distributed throughout the original tissue section, and immunostaining of the Nesi B subculture demonstrated well-differentiated heavily granulated insulin-positive cells, each with a normal modal number of chromosomes (46). Nesi B cell-associated macromolecules were isolated in 3 x 10(-3) ethylenedinitrilotetraacetate/phosphate-buffered saline and were found to be reactive with a heterologous immune serum elicited to a cloned rat pancreatic beta-cell line (RIN-5F). Western (immuno) blotting showed this immunoreactivity to reside primarily in a 95-kDa fraction of Nesi B-derived components. These results indicate that human nesidioblasts can be cultured for a sufficient number of passages to allow isolation and immunochemical characterization of pancreatic beta-cell macromolecules shared between rat and human and that may serve as organ-specific antigens for inflammatory disorders of the pancreas.

Animals↗