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Biomedical subjects

H Iwama

Publications and source records attributed to H Iwama.

106 records · Page 6Linked to original sources
PubMed1992

[A study of cerebral circulation following cervical sympathetic ganglion block].

Cerebral circulation following cervical epidural block or stellate ganglion block at the transverse process of the 6th cervical vertebra (C6-SGB) was evaluated by single photon emission computed tomography of inhaled Xenon-133. Cerebral blood flow before and 15 min after both blocks was measured in eight patients after cervical epidural block and ten patients after C6-SGB. Cerebral blood flow decreased slightly following cervical epidural block, but it was not a statistically significant difference. Cerebral blood flow following C6-SGB could be separated into two groups; in one it increased and in the other it decreased slightly. In conclusion, cerebral circulation is not influenced by cervical epidural block, but it is probably affected by C6-SGB. The manner in which C6-SGB increases cerebral blood flow seems that local anesthetics reached the superior cervical ganglion and block it. C6-SGB without superior cervical ganglion block does not influence cerebral circulation, and it only dilates extracranial vessels.

Adult↗
PubMed1989

A new pharmacological testing method--different effects of levamisole and the serum of mice orally treated with levamisole on mitogenic activity of lipopolysaccharide.

The direct addition of levamisole to murine splenic lymphocytes had no effect on the mitogenic activity of lipopolysaccharide. However, the addition of serum of mice orally treated with levamisole increased the mitogenic activity, and this increased activity using serum was similar to the result obtained in an in vivo experiment. These results suggest that the new in vitro experimental method using serum may be able to reproduce the in vivo effect of drugs.

Animals↗
PubMed1989

Ruthenium red and magnesium ion partially inhibit silver ion-induced release of calcium from sarcoplasmic reticulum of frog skeletal muscles.

Effects of Ca2+-induced Ca2+ release blockers, ruthenium red (RR) and Mg2+, on Ag+-induced Ca2+ release were studied using skinned muscle fibers or fragmented heavy SR (HSR) prepared from frog muscle, and compared with those on caffeine-induced one. Exposure of the skinned fibers to 5 microM Ag+ produced a rapid and large contraction in the presence of 0.043 mM free Mg2+. When Mg2+ concentration was increased to 0.86 mM, Ag+ led to a large transient contraction, combined with a small tonic one. The transient component was completely blocked by high Mg2+ (3.64 mM), but the tonic one was not. Ca2+-ATPase activity was not stimulated by increase of Mg2+ from 0.86 to 3.64 mM. Ag+ and caffeine induced a rapid Ca2+ efflux from HSR in a dose-dependent manner. RR over a range from 1 to 10 microM dose-dependently inhibited the Ca2+ efflux induced by 10 microM Ag+. Despite increase of RR to 30 microM, however, further inhibition of the Ca2+ efflux was not produced any more (77.8 +/- 12.2% inhibition). A 10 mM caffeine-induced efflux of Ca2+ was blocked slightly by only 0.5 microM RR and almost completely by 3 microM. A slight inhibition (about 28%) of the Ca2+-ATPase activity was observed in the presence of 10 microM Ag+ in 0.5 mg SR protein/ml of medium. RR and caffeine did not affect the enzyme activity. These results indicate that frog SR could induce a rapid release of Ca2+ upon Ag+ and caffeine, suggesting that Ag+ may have two different binding sites to release Ca2+; one is on Ca2+-induced Ca2+ release channel and the other on RR-insensitive site.

Animals↗
PubMed1986

Effects of five kampohozais on the mitogenic activity of lipopolysaccharide, concanavalin A, phorbol myristate acetate and phytohemagglutinin in vivo.

Mitogenic activity of lipopolysaccharide (LPS), concanavalin A (Con A), phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) were investigated using spleen cells prepared from C57BL/6 mice orally pretreated with one of five kampohozai extracts (Shosaikoto, Daisaikoto, Hochuekkito, Juzendaihoto and Tokishakuyakusan). Shosaikoto and Daisaikoto elevated the mitogenic activity of LPS and reduced those of Con A. The mitogenic activities of PMA and PHA were elevated by low doses of Shosaikoto and Daisaikoto and suppressed by high doses. Juzendaihoto and Tokishakuyakusan showed no effect on the mitogenic activity of LPS and Con A, but increased those of PMA and PHA. Hochuekkito increased the mitogenic activity of LPS, Con A, PMA and PHA. In the absence of mitogens, these five kampohozais showed no mitogenic activity. These results indicate that the kampohozais used in this experiment appear to possess the immunomodulating or immunostimulating activities that might be expected from clinical experiences in Japan and China.

Adjuvants, Immunologic↗
PubMed1986

Studies of the combined use of steroid and Shosaikoto, one of the Kampohozai (Chinese traditional medicine), on pituitary adrenocortical axis function and immune responses.

The combined effects of Shosaikoto, one of the Kampohozai (Chinese traditional medicine), and prednisolone were examined for suppressive actions on pituitary adrenocortical axis function and immune response induced by prednisolone using rats and mice. The administration of Shosaikoto, 1.2 g/kg p.o., for 45 d showed a tendency to increase adrenal weight. By the combined use of Shosaikoto, 0.12 and 1.2 g/kg p.o., and prednisolone, 0.016 g/kg p.o., for 45 d, the decrease of adrenal weight induced by the treatment with prednisolone was restored. The administration of Shosaikoto, 1.2 g/kg p.o., elevated the blood corticosterone level. In the case of combined use, Shosaikoto, 0.12 and 1.2 g/kg p.o., inhibited the decrease of blood corticosterone level induced by the treatment with prednisolone, 0.004 g/kg p.o., and Shosaikoto, 1.2 g/kg p.o., inhibited the decrease of blood corticosterone level induced by the treatment with prednisolone, 0.016 g/kg p.o. On the other hand, the administration of Shosaikoto, 1.2 g/kg p.o., for 7 d reduced the number of hemolytic plaque forming cells (HPFC) in spleen cells. But, Shosaikoto, 1.2 g/kg p.o., administered for 7 d inhibited the decrease of the number of HPFC induced by the treatment with prednisolone, 0.01 and 0.03 g/kg s.c., for 3 d. Furthermore, Shosaikoto, 1.2 g/kg p.o., restored the number of rosette forming cell (RFC) which decreased by prednisolone, 0.03 g/kg s.c. The decrease of 7S HA titer of the serum by the treatment with prednisolone, 0.01 g/kg s.c., was also inhibited by the combination with Shosaikoto, 1.2 g/kg p.o.

Adrenal Glands↗
PubMed1982

[An autopsy case of Parkinson's disease associated clinically with dementia terminating in akinetic mutism and pathologically with multiple Lewy's Bodies in the cerebral cortex].

An autopsy case of a 50 year-old male with Parkinson's disease associated with multiple Lewy bodies in the cerebral cortex was reported. His clinical symptoms began at the age of 26 with the speech and actions indicative of a persecution complex accompanied by irritability and were followed by progressive dementia from the age of 37 and Parkinsonism since the age of 41. He was in a state of akinetic mutism thereafter till his death at the age of 50. Autopsy disclosed in addition to the typical findings of Parkinson's disease in the brain stem multiple intracytoplasmic Lewy bodies in medium-sized neurons of the fifth and sixth layers of the cerebral cortex. They were atypical in the sense that they did not have any haloes. They were especially numerous in the cingulate gyrus. In addition, findings of non-specific neuronal degeneration were obtained in the cerebral cortex such as cellular atrophy with massive deposition of lipofuscin pigments, central chromatolysis, cell loss and cellular gliosis in the third, fifth and sixth layers. These neuronal findings were also prominent in the cingulate gyrus. Such senile changes as senile plaques or granulo-vacuolar degeneration were not found, although there were a few foci of neurofibrillary degeneration in the hippocampal gyrus. Histochemically and electron microscopically, no difference was observed in the constituents of Lewy bodies between the brain stem and the cerebral cortex. Such autopsy findings and a review of the literature indicate that the dementia in this case may be related not only to the presence of Lewy bodies but also to the above-described, non-specific neuronal degeneration in the bilateral cingulate gyri and surrounding frontal gyri. The standpoint of regarding a Parkinson's disease with multiple Lewy bodies in the cerebral cortex as an independent disease entity was criticized.

Akinetic Mutism↗
PubMed1977

[Therapeutic effect of pipemidic acid trihydrate on urinary tract infections (author's transl)].

Twenty-seven cases of urinary tract infection were treated with daily dose of 1.5 g of pipemidic acid trihydrate. Duration of drug administration varied between 7 and 28 days. The patients were consisted of acute cystitis (10), underlying disease (5) and complicated infection after long period catheterization (12). Following results were obtained: 1. Organisms cultured before treatment were sensitive to pipemidic acid trihydrate. 2. First and second classes of patients were cured by the treatment, however, patients having indwelling catheter were not changed on the view of culture. 3. No serious side effect was observed including hepatic and renal function, and blood.

Adult↗
PubMed1976

[Bonding strength between porcelain and gold alloys. (2) The effects of iron, indium and tin (author's transl)].

Ten kinds of alloys were prepared for testing by addition of 0-0.75 wt% iron, indium and tin (total amount 0.75 wt%) to base alloy, 88 Au-6 Pt-5 Pd-1 Ag. Opaque porcelain (Ceramco Inc.) was fused to these alloys according to the manufacturer's directions. The bonding strength was determined by the shear bond test that had been described in the preceding paper and the effects of the trace elements were examined.

Dental Bonding↗
PubMedDate not supplied

Effect of shosaikoto, a Japanese and Chinese traditional herbal medicinal mixture, on the mitogenic activity of lipopolysaccharide: a new pharmacological testing method.

Two in vitro experimental systems were compared to evaluate the pharmacological effects of Shosaikoto, a Japanese and Chinese traditional herbal medicinal mixture, on the mitogenic activity of lipopolysaccharide (LPS) using murine splenic cell culture. The first system involved the addition of serum obtained from mice treated orally with Shosaikoto while the second system involved the direct addition of Shosaikoto to the medium. Both systems were performed in parallel. Prednisolone decreased the mitogenic activity of LPS in a dose-dependent manner in both experimental systems. On the other hand, the serum of mice pretreated with Shosaikoto increased the mitogenic activity of LPS with constant cell viability, although the serum showed no mitogenic activity in the experiment without LPS. When Shosaikoto was added to the medium directly at more conventional doses, the mitogenic activity of LPS was elevated with an increase of cell viability. In the experimental system without LPS, Shosaikoto itself showed mitogenic activity. In other experiments, the mitogenic action of LPS was investigated using spleen cells of mice orally pretreated with Shosaikoto for 7 days. Mitogenic action of LPS was increased in the spleen cells of Shosaikoto-treated mice compared with the control. However, in the same experimental system without LPS, mitogenic action was not recognized in the spleen cells of Shosaikoto-treated mice.

Animals↗
PubMedDate not supplied

Interpleural block for patients with multiple rib fractures: comparison with epidural block.

Interpleural block (IPB) was compared with epidural block (EB) in 17 adults with unilateral multiple rib fractures and hemopneumothorax. The study was a randomized, crossover, before-after trial on the first and second hospital days. An IPB catheter was inserted along with a chest tube, and an upper thoracic EB was also established in the same patient. We administered 10 ml of 1% lidocaine for both blocks. The range of thermohypesthesia was unilateral and shorter in IPB, whereas it was bilateral and wider in EB. The effects of pain relief were almost the same. Respiratory rate decreased, and PaO2 tended to elevate similarly. In IPB, systemic blood pressure changed minimally, but it fell significantly in EB, which would be a disadvantage of EB in trauma patients. Serum levels of lidocaine were similar and in the safe range. The technique of IPB seemed to be easier than EB. In conclusion, IPB with lidocaine is as effective for pain relief as EB.

Adult↗
PubMedDate not supplied

The association between injected volume of local anesthetic and spread of epidural anesthesia: a hypothesis.

BACKGROUND AND OBJECTIVES: Clinically, an increase of the injected volume of local anesthetic does not result in a linear increase in the spread of epidural anesthesia. This study was designed to evaluate this observation. METHODS: One-hundred twenty adult women undergoing abdominal gynecologic surgery were randomly assigned into 6 groups of 20 patients each. An epidural catheter was inserted in each patient via the L1-L2 interspace, and 2, 4, 6, 8, 10, and 12 mL of 2% mepivacaine was injected, respectively, in each group. Fifteen minutes later, the cephalad extent of hypesthesia above the second sacral dermatome was tested with an alcohol swab. RESULTS: The regression analysis between injected volume (x mL) and number of anesthetized dermatomes (y) approximates a cubic polynominal equation rather than a simple equation, as follows; y = 3.021 x - 0.274 x2 + 0.009673 x3 (R2 = 0.938, P = .0435). CONCLUSIONS: The present study demonstrates lack of a linear relationship between injected volume of local anesthetic and spread of epidural anesthesia. Whether the cubic equation developed is clinically useful remains unclear because of the variability of the data.

Adult↗
PubMedDate not supplied

Water-diluted local anesthetic for trigger-point injection in chronic myofascial pain syndrome: evaluation of types of local anesthetic and concentrations in water.

BACKGROUND AND OBJECTIVES: We have recently demonstrated that a mixture of 1% lidocaine with water in a 1:3 ratio has less injection pain and is more effective than unaltered 1% lidocaine in treating chronic myofascial pain syndromes. Yet, the most suitable local anesthetic and the most effective dilution in water have not been evaluated. METHODS: Various mixtures of local anesthetics and water or saline were injected intramuscularly into the shoulder of 40 female volunteers, and pain scores on injection were evaluated in a randomized and double-blinded manner. In another portion of the study, 0.25% or 0.2% lidocaine in water were injected randomly into 1 side of 21 outpatients with chronic neck, shoulder, or lumbar myofascial pain to the same degree in both sides. The other solution was injected into the other side of the same patients. RESULTS: Less injection pain was experienced with the water-diluted 0.25% lidocaine and water-diluted 0.25% mepivacaine than the saline-diluted 0.25% lidocaine and water-diluted 0.0625% bupivacaine. Also, less injection pain was experienced with the water-diluted 0.25% and 0.2% lidocaine than the water-diluted 0.3% and 0.15% lidocaine. In the other study, there were no differences in either the effectiveness or duration of analgesia between the 0.25% and 0.2% water-diluted lidocaine. CONCLUSIONS: The suitable type of local anesthetic may be lidocaine or mepivacaine, and the most effective water-diluted concentration is considered to be 0.2% to 0.25%.

Adult↗