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Biomedical subjects

H Ising

Publications and source records attributed to H Ising.

At least 37 records · Page 2Linked to original sources
PubMed1987

Alterations of electrolytes in serum and erythrocytes after myocardial infarction.

Electrolyte concentrations in serum and erythrocytes of 56 myocardial infarction (MI) patients and 50 patients having had an orthopedic operation or an accident were measured up to 2 weeks after the event. Several hours after the MI, considerable percentages of patients had had pathologically low serum concentrations of either K, Ca or Mg. In the erythrocytes of the Mi group, K was decreased and Ca increased during the entire period of investigation, whereas the serum electrolytes K and Ca had normalized by day 15, at which time only half of the patients with pathologically low serum Mg had reached the normal Mg range. By correlation analysis it was shown that the more the Ca concentration in the serum was decreased after MI, the less was the concentration of brain muscle creatine kinase.

Adult↗
PubMed1986

The metabolic effects of thiazide therapy in the elderly: a population study.

The metabolic consequences of thiazide diuretics are well known. The elderly to whom these agents are widely prescribed may be particularly susceptible. To quantify this metabolic risk, plasma and intracellular electrolytes and plasma glucose were measured in the elderly population of a Somerset village. Highly significant reductions in both plasma and cellular magnesium and potassium were found in the 47 thiazide-treated people. Forty-eight per cent of the thiazide-treated group were hypomagnesaemic and 28% were hypokalaemic. Thus, magnesium and potassium depletion are commonly associated with thiazide therapy in the elderly. These metabolic effects should be considered carefully prior to the use of these agents.

Aged↗
PubMed1986

High-frequency audiometry using precision earphones: reliability under laboratory and field conditions.

New circumaural earphones were tested in the frequency range from 100 Hz to 20 kHz and compared to commonly used supra-aural earphones. The circumaural earphone HD 230 (Sennheiser) generates test stimuli at up to 20 kHz with almost constant sound pressure levels when its pos ed on an artificial ear. The reproducibility of hearing threshold mea ed with a new microprocessor-controlled Békésy audiometer using the ne was nearly as good as under free-field conditions. The practicabil diagnostic value of high-frequency audiometry have been demonstrated er field conditions. For this application, the good sound attenuation these earphones (30 dB above 1 kHz) are important. High-frequency he ds of healthy pupils and of pupils with a history of otitis media are kHz, the hearing threshold level difference between both groups reached 20 dB.

Adolescent↗
PubMed1985

Electrolytes and ventricular arrhythmias.

Magnesium concentrations in the blood plasma of patients with ventricular arrhythmias were found to be significantly lower than in controls, whereas the sodium and calcium concentrations of the erythrocytes were significantly higher than in the controls. Intensive magnesium therapy resulted in an increase of the plasma magnesium concentration and in significant changes of Na, K, Ca and Mg in the erythrocytes. By means of long-term ECG recordings, it was shown that the therapy may result in a quantitative decrease of the ventricular arrhythmias.

Aged↗
PubMed1984

Magnesium deficiency and hypertension: correlation between magnesium-deficient diets and microcirculatory changes in situ.

Rats maintained for 12 weeks on diets moderately or more severely deficient in magnesium showed significant elevations in arterial blood pressure compared to control animals. Examination of the mesenteric microcirculation in situ revealed that dietary magnesium deficiency resulted in reduced capillary, postcapillary, and venular blood flow concomitant with reduced terminal arteriolar, precapillary sphincter, and venular lumen sizes. The greater the degree of dietary magnesium deficiency the greater the reductions in microvascular lumen sizes. These findings may provide a rationale for the etiology, as well as treatment, of some forms of hypertensive vascular disease.

Animals↗
PubMed1983

Dependence of noise-induced hearing loss upon perilymph magnesium concentration.

Noise-induced hearing loss (NIHL) is significantly greater in rats fed a magnesium-deficient diet than in rats on a magnesium-rich diet. The hearing loss was found to be negatively correlated with the magnesium concentration of the perilymph. It is suggested that also in man, the magnesium concentration in the perilymph may be of importance in determining susceptibility to NIHL.

Animals↗
PubMed1982

Increased noise trauma in guinea pigs through magnesium deficiency.

Mg-deficient guinea pigs developed significantly increased hearing loss during 4 weeks of noise exposure [95 dB(A)] as compared to animals fed a Mg-rich diet. The hearing loss was negatively correlated to the Mg content of the perilymph (r = -0.86). Besides this auditory effect, there was a decrease of intracellular Mg and an increase of collagen in the myocardium, both of which were correlated to the hearing loss and caused by Mg deficiency and noise stress.

Animals↗
PubMed1981

Embryotoxic effects of magnesium deficiency and stress on rats and mice.

Pregnant rats an mice received a magnesium (Mg)-deficient diet with different Mg contents from 40 t 360 ppm. The control received 2,000 ppm. At the end of gestation, the Mg concentration in the maternal serum was found to have decreased by up to 0.3 mmole/liter, depending on the Mg content of the food. Mg-dose-dependent embryotoxic effects (resorptions, retardation, disturbed bone development, and skeletal malformations) were observed only below a threshold value of 0.7 mmole/liter of the maternal serum Mg concentration. Noise stress in rats, in addition to a mild Mg deficiency (360 ppm Mg), which by itself had no effects, increased the rate of resorptions only.

Animals↗
PubMed1981

Strong association of idiopathic membranous nephropathy (IMN) with HLA-DR 3 and MT-2 without involvement of HLA-B 18 and no association to BfF1.

The present study investigated the distribution of HLA-antigens and Bf alleles in a group of 21 patients suffering from biopsy proven Idiopathic Membranous Nephropathy (IMN). A statistically significant increase of HLA-DR3 (76.2%) was detected in the patient group as well as an increase of MT-2 (86%), which is a new supertypic specificity defined within the 8th International Histocompatibility Workshop 1980. No association between BfF1 and IMN can be deduced from this study. Only the common Bf alleles (BfFF, BfFS, BfSS) were found in the patient group presented here. Also the previously reported association between HLA-B18 and IMN was not corroborated by this study. Not a single IMN-patient typed positive for HLA-B18. Thus the presence of two different HLA-DR-Bf-B linkage groups (HLA-DR3/BfF1/HLA-B18 and HLA-DR3/Bf; all alleles/HLA-B8) may point to at least two different immunological mechanisms underlying IMN.

Adolescent↗
PubMed1981

Interaction of noise-induced stress and Mg decrease.

A feedback mechanism between noise stress and Mg decrease is postulated. The two sides of the interaction between noise stress as a model of general stress and cellular Mg decrease with possible Ca increase are demonstrated in laboratory and field studies with rats and human test persons.

Animals↗
PubMed1980

Health effects of traffic noise.

In 57 test persons having worked 1 day under traffic noise (Leq = 85 dB(A) and 1 day without noise (Leq < 50 dB(A), blood pressure and pulse frequency were measured at 1 h intervals and total urine was collected during working hours. Additionally, blood was sampled at the end of each working day. Psychological parameters were assessed by means of questionnaires. Statistically significant reactions to noise were found in the following fields: 1. Ergnomics--decrease of working quality; 2. Psychology--increase of psychical tension; 3. Blood circulation--increase of blood pressure and pulse frequency; 4. Biochemistry--increase of epinephrine, cAMP, urine and serum Mg, protein, cholesterol plus decrease of erythrocyte Na, and renin. Hypothetical mechanisms of the action of traffic noise are discussed.

Adolescent↗
PubMed1978

Thiouracil-induced myocardial fibrosis.

Rabbits were fed with thiouracil for 8 months. Subsequently their hearts were examined electron microscopically as well as biochemically for collagen and hexosamine content. Chronic treatment with thiouracil induced an increase in interstitial connective tissue collagen and hexosamine without visible necrosis. As seen by electron microscopy, the increase in collagen content might have been caused by stimulation of the fibrocytes. Furthermore, the heart muscle cells showed deep indentations and bulges of the cell membrane and an enlargement of the T-system.

Animals↗
PubMed1978

[Electrolyte and collagen content of rat heart in chronic Mg-deficiency and stress (author's transl)].

In chronic Mg-deficiency, there is a decrease in the content of Mg and K+ in the heart muscle. The contents of Ca, Na+ and hydroxyproline increase. There is also an increased urinary excretion of adrenaline and especially noradrenaline. With simultaneous noise stress, these changes are even greater. The magnitude of the changes increases with the degree of Mg-deficiency. The changes in the contents of Na+, K+, Ca, Mg and hydroxyproline correlate with the excretion of noradrenaline. The increase in the collagen content can be verified by electron microscopy, and it is due to a stimulation of the fibrocytes.

Calcium↗