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Biomedical subjects

H Ishida

Publications and source records attributed to H Ishida.

At least 901 records · Page 50Linked to original sources
PubMed1985

The role of vitamin D metabolites in hypercalcemia of Zucker fa/fa rats.

In order to investigate mineral and vitamin D metabolism in obese rats with hyperinsulinemia, plasma calcium and vitamin D metabolites were measured in Zucker fa/fa rats. Body weight, plasma insulin, and calcium in fa/fa rats were significantly increased compared to their lean littermates (p less than 0.01). However, no significant difference in plasma 25-hydroxyvitamin D (25(OH)D), 24,25-dihydroxyvitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) or the ratio of 1,25(OH)2D to 25(OH)D was observed between fa/fa rats and their lean littermates. The hypercalcemia in the rats with hyperinsulinemia, therefore, might be caused by other calcium-regulating hormones or some factors other than 1,25(OH)2D. In addition, the hyperinsulinemia associated with obesity may not produce the accelerated conversion from 25(OH)D into 1,25(OH)2D.

24,25-Dihydroxyvitamin D 3↗
PubMed1985

Interrelationship of some selected nutritional parameters relevant to taste for salt in a group of college-aged women.

Students in a women's college were investigated for taste acuity for salt, discrimination of salt concentrations in food, and anthropometrical (the body mass index, and systolic and diastolic blood pressures) and biochemical nutritional parameters (blood hemoglobin, plasma zinc, plasma copper, plasma vitamin A, plasma retinol-binding protein, urinary sodium, urinary potassium, urinary magnesium, urinary calcium and urinary zinc). Among 95 students who participated in the test for discrimination of salt concentrations, which was repeated 6 times with 5 different test samples, only 43 (45.3%) committed no mistakes. The detection threshold for taste of salt was significantly associated with neither the discriminability of salt concentrations nor any biochemical parameters. Levels of plasma zinc (PZn), urinary zinc (UZn) and plasma vitamin A (VA) were lower in the present subjects than in those reported previously. The rate of correct discrimination (RCD) was significantly correlated with PZn and VA positively, and with urinary sodium (UNa) and urinary potassium (UK) negatively. In the factor analysis to investigate the interrelationship of nutritional parameters, 6 factors with significance were extracted, among which factors 3 and 4 were related to RCD. Factor 3 had large loadings on VA, plasma retinol-binding protein (RBP) and RCD, and factor 4 was positively loaded on UNa and UK and negatively on UZn and RCD. In the stepwise multiple regression analysis (RCD being the dependent variable), significant independent variables selected were VA, UK, PZn, systolic blood pressure and UNa. From these results, the college-aged women's failure in discriminating salt concentrations in food was likely to be related to vitamin A inadequacy, mild Zn deficiency and excessive intakes of Na and K.

Adolescent↗
PubMed1985

Osteopenia and circulating levels of vitamin D metabolites in diabetes mellitus.

The degree of diabetic osteopenia and serum vitamin D metabolite levels were measured in 14 type 1 (insulin-dependent) and 168 type 2 (non-insulin-dependent) diabetic patients. Based on six indices obtained by microdensitometry, we found the bone mass in 28.6% of type 1 and 26.2% of type 2 diabetic patients to be decreased and in 14.3% and 11.9%, respectively, the decrease was severe. Our method of analysis of bone mass has shown that diabetic osteopenia differs from typical osteoporosis in character. In addition, serum 24,25-dihydroxyvitamin D was significantly decreased both in type 1 and in type 2 diabetes (p less than 0.01), but 1,25-dihydroxyvitamin D was significantly decreased only in type 1 diabetes (p less than 0.01) compared to the controls, being lower than that in type 2 diabetes (p less than 0.05). On the other hand, 25-hydroxyvitamin D was similar to that of the controls, in both types of diabetes.

24,25-Dihydroxyvitamin D 3↗
PubMed1985

Diabetic osteopenia in central Japan.

A large scale study of diabetic osteopenia was conducted in central Japan. The degree of bone mass loss was measured in 1267 diabetic patients and 646 control subjects. Based on six indices obtained by microdensitometry, the bone mass of 21.1% of the diabetic patients was found to be markedly decreased and that of 8.2% was found to be severely decreased, while only 7.9% of the control group showed bone mass loss. The prevalence of diabetic osteopenia in female patients was significantly higher than in males, but a positive correlation between the degree of bone mass loss and age was observed in both the male and female patients. Patients requiring oral agents or insulin had significantly more bone mass loss than those on dietary therapy alone.

Adolescent↗