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H Iizumi

Publications and source records attributed to H Iizumi.

13 recordsLinked to original sources
PubMed1995

Immunohistochemical alterations in neuropeptide Y-positive nerve elements in rat cerebral cortex following acute phencyclidine treatment.

Phencyclidine (PCP) is a dissociative drug and has been known to be an antagonist of N-methyl-D-aspartate (NMDA) receptor. We examined possible effects of acute treatment with PCP on neuropeptide Y (NPY) immunoreactive nerve fibres and cell bodies in rat forebrain by immunocytochemistry combined with morphometric analysis. Following the treatment, significant alterations were observed throughout the cerebral cortex, compared with controls. NPY-positive perikarya were increased in number (178%) whereas NPY-positive fibres and terminals were decreased in area (38%). The result suggests that the cortical NPY neuronal system is controlled, at least partly, by glutamatergic inputs via NMDA receptor-mediated mechanisms.

Animals↗
PubMed1995

Visible light-sensitized oxidation of arachidonic acid in the presence of inperatorin.

To understand the mechanism of the phototoxic effects of inperatorin, a psoralen derivative used as a pigmentation agent, we have investigated the photosensitized oxidation of arachidonic acid (ARA) by irradiation with visible light (> 400 nm) in the presence of inperatorin. HPLC and GC/MS analyses of the products showed the formation of many hydroperoxyeicosatetraenoic acids (HPETEs) including the products of lipoxygenase-catalyzed reactions such as 5- and 15-HPETEs, which are the precursors of chemical mediators such as leukotrienes and lipoxins, during the reaction. Active oxygen scavening agents such as D-mannitol, superoxide dismutase, and beta-carotene inhibited the formation of the oxidation products, indicating that the oxidation reaction was mediated by various active oxygen species. These results suggest that the phototoxic effects of inperatorin could also be induced by visible light and could be explained at least partially in terms of inflammation initiated by the biologically active HPETEs arising from photosensitized oxygenation reactions of ARA with the drug.

Arachidonic Acid↗
PubMed1994

[Support system for long-term morphine administration to terminal cancer patients at home--verification from three patients at home with terminal cancer].

The nursing department at the Saitama Prefectural Cancer Center established a Nursing Consultation Section in April 1993 and a Visiting Nursing Program in May 1993 with the purpose of supporting cancer patients who desired home care. From these dates through March 1994, 1,021 patients were instructed in home care methods and visiting nursing was provided in 98 cases. Of these, three patients with terminal cancer received long-term ameliorative treatment using orally administered morphine and were able to maintain satisfactory QOL through their terminal periods. The results are reported herein.

Aged↗
PubMed1994

Microprocessor-based memory device for ambulatory heart rate and physical activity recording.

Using microprocessor techniques, a portable digital memory device has been designed for the ambulatory monitoring of heart rate and physical activity. The device consists of a microprocessor, an ECG amplifier to record the heart rate and an accelerometer to detect the physical activity. This accelerometer is piezo-resistive and is suitable for ambulatory physical activity recording, because this sensor requires low electrical power, has high durability and wide frequency response (DC approximately 1.2 kHz). Changes in heart rates and physical activity in daily life have been successfully recorded.

Computer Storage Devices↗
PubMed1993

[Efficacy of influenza vaccination and its relationship to daily absentee rate].

To determine the efficacy of influenza vaccination and it's relationship to "daily physical condition", an investigation was carried out in two elementary schools and one junior high school. Since children who had many absences during the first and second trimesters, tend to have many absentee days in the third trimester and during the last year, also, absentee rate during the first and second trimesters was considered to be an indicator of "daily physical condition". Vaccinated children tended to have lower absentee rates than nonvaccinated children during the first and second trimesters. This indicates that there is a definite difference between vaccinated and nonvaccinated children in terms of "daily physical condition". Children who had many absences during the first and second trimesters, also tended to have many absentee days during the influenza season, introducing a confounding factor, "daily physical condition", when comparisons are made in the absentee rate between vaccinated and nonvaccinated children during the influenza season. Careful analysis of these data, taking into account their "daily physical condition", showed that vaccinated children tended to have lower absentee rates than the nonvaccinated during the influenza season. However there was no definite difference between vaccinated and nonvaccinated children in length of absentee days during the influenza season.

Absenteeism↗
PubMed1989

Effect of physical training on thrombotic tendency in rats: decrease in thrombotic tendency measured by the He-Ne laser-induced thrombus formation method.

The effect of physical training on thrombotic tendency was assessed in rats. Exercise was done on a flat treadmill for 30 min at a rate of 1,400 m/h (submaximal speed), 5 times a week for either 1.5 or 3 months. The thrombotic tendency was measured by the He-Ne laser-induced thrombus formation method in microvessels of mesentery, i.e. measurement of the number of laser irradiations necessary to induce stasis of blood flow by occlusive thrombus formation. An increase in the number of irradiations necessary to induce occlusive thrombus formation was observed in arterioles, but not in venules after physical training for 1.5 and 3 months.

Animals↗
PubMed1986

Effect of food consumption pattern on total serum cholesterol level: a methodological approach.

The food intake and serum cholesterol levels of 60 healthy, middle-aged inhabitants of Kobe city were surveyed from 1974 to 1981. We attempted to estimate the serum cholesterol level in which food consumption patterns (8-factor scores) were chosen as dietary indicators. Every two years, multiple regression analysis was applied cross-sectionally for males and females, using the eight factor scores as independent variables and the total serum cholesterol level as a dependent variable. The multiple regression coefficients based on the factors were significant for both males and females. Reproducibility of the standard partial regression coefficients, beta, for females was also high. We obtained a formula for estimating serum cholesterol level based on the scores of Factor 1 (staple foods), F5 (prepared foods), F6 (traditional Japanese foods), F7 (vegetable oil) and F8 (nutrition-consciousness): multiple regression coefficient R = 0.56 and coefficient of determination R2 = 0.31. The multiple regression equation indicated that serum cholesterol level increased with the combined effects of the uniformity of the food life, westernized-type food consumption, concern for nutrition and a relatively low intake of vegetable oil.

Adult↗
PubMed1986

Eleven-year follow-up of changes in individuals' food consumption patterns.

In 101 healthy middle-aged persons of both sexes, changes in dietary were followed up for 11 years 1974 to 1984. As dietary indicators, the food consumption pattern, 8 factors obtained by factor analysis, was used. The factors were evaluated for changes with age in each person and each sex. Changes with age were observed for the food consumption patterns: There was a general tendency in the group for the staple food factor to change in the direction of a Westernized food the same time, the group generally changed in the direction of less intake of sweets and of animal fats. From the standpoint of nutrients, the changes over this period were a decrease in the energy intake, in the percentage of energy from carbohydrate, of energy from alcohol, which caused a slight increase in the percentage of energy from protein and fat. The main factors in the changes was physiological changes that accompany the process of aging, changes in the consciousness of health, and changes in the food environment.

Adult↗
PubMed1986

Physical conditions affecting food consumption patterns.

From the point of view of food counseling, we studied the coefficients of cross correlation in the relationship of physical conditions and eating behavior. For the 11 years from 1974 to 1984, we monitored 101 healthy middle-aged persons in terms of the food intake and several indicators of health. Of the various indicators, the systolic blood pressure (SBP), the diastolic blood pressure (DBP), total cholesterol in the serum (TOTAL-C), beta-lipoprotein (beta-LIPO), and relative weight, all risk factors in atherosclerosis, were used as physical conditions. For the diet indicator, we used eight factors in the food consumption pattern. We calculated the correlation for individuals between these indicators. The clinical data, with the exception of systolic blood pressure, affected the food consumption pattern, and a mutual feedback between the physical conditions and the diet seemed to be possible. The correspondence for the food intake of individuals to physical conditions did not contradict current knowledge about nutrition.

Adult↗