Search PubMed⌕ Search

Biomedical subjects

H Igisu

Publications and source records attributed to H Igisu.

88 records · Page 5Linked to original sources
PubMed1979

Erythrocyte ATP in Duchenne dystrophy: effects of ouabain and propranolol.

The ATP and lactate contents of erythrocytes from patients with Duchenne muscular dystrophy (DMD) were measured before and after incubation with or without glucose plus either ouabain or propranolol. Samples from patients and controls were obtained at almost the same time on the same day and processed simultaneously. The erythrocyte ATP content differed in adults and children, but there was no difference between DMD patients and age-matched controls. Ouabain suppressed, and propranolol enhanced, the changes of ATP and lactate, to the same extent in patients and in controls. We found no gross abnormalities in generation and utilization of ATP in erythrocytes in DMD, and the response to ouabain or propranolol appeared normal.

Adenosine Triphosphatases↗
PubMed1976

Effects of taurine on the ATPase activity in the human erythrocyte membrane.

Effects of taurine on the total ATPase activity inhibited by ouabain were investigated in the human erythrocyte membrane. The enzyme activity was not activated by taurine in the absence of calcium, but was significantly activated by taurine (15-60 mM) in the presence of calcium (5 mM) by which the enzyme is inhibited. Since taurine does not form a chelate complex with calcium ion, this activation may be due to an action of taurine in the presence of calcium through competition with these ions on the membrane.

Adenosine Triphosphatases↗
PubMed1975

Acrylamide encephaloneuropathy due to well water pollution.

All five members of a family developed subacutely mental confusion and/or truncal ataxia. Symptoms and signs of polyneuropathy were seen later. The well water in the patients' home contained 400 ppm acrylamide. The present cases are unique in that they are cases of acrylamide poisoning induced by oral intake and percutaneous penetration, and that central nervous system symptoms were prominent.

Acrylamides↗
PubMed1975

Giant axonal neuropathy. A clinical entity affecting the central as well as the peripheral nervous system.

An 8-year-old girl had progressive muscle weakness and a unique posture of the lower limbs, areflexia, distal sensory impairment, and remarkably kinky hair. Histologic examination of the sural nerve showed giant axons filled with neurofilamentous masses. The clinical and histologic findings resembled those of recent cases reported as "giant axonal neuropathy." Our patient's precocious puberty, Babinski's sign, and electroencephalographic abnormalities suggested central nervous system involvement. Two cases previously reported and the present one appear to represent a new clinical entity that affects the central and the peripheral nervous system.

Axons↗