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Biomedical subjects

H Ide

Publications and source records attributed to H Ide.

At least 433 records · Page 24Linked to original sources
PubMed1981

[A case report of a primary pure squamous cell carcinoma of the stomach associated with dermatomyositis (author's transl)].

A 54-yr-old man was admitted to Hokkaido University Hospital, complaining of fever, multiple arthralgia, edematous erythema and face and muscular weakness of extremities during the last 2 months. He was diagnosed as dermatomyositis by acceleration of ESR, elevation of GOT, GPT, CPK, aldolase, moderate increases of collagen fibers in biopsy specimen of skin and his clinical signs. Although stools were positive for occult blood, the routine radiographic examination failed to detect the bleeding site in the upper GI. tract. However, in the double contrast picture of the stomach, a very fine abnormal linear shadow was observed at the upper corpus of the lesser curvature. This linear shadow was a margin of the tumor, retrospectively. About 4 months later, abnormal pain occurred and a mass was palpable in the left lumbar region, suggesting a pancreatic tumor. He was operated on excising the tumor, but was performed only exploratory laparotomy because of the presence of intra-abdominal metastases. Death occurred 40 days after the operation and necropsy was done. The gross anatomical findings of the abdomen showed a stomach tumor as large as an infant's head and its metastases to pancreas, lymph nodes, and greater and lesser omentum. Esophageal mucosa including esophagocardiac junction was intact. Histological examination of the intragastric tumor revealed a typical squamous cell carcinoma with keratinization. According to the absence of the components of adenocarcinoma and squamous metaplastic gastric mucosa of non-cancerous areas in the stomach, it seemed likely to be a heterotopic squamous cell carcinoma. It was unknown about the precedence between the stomach cancer and dermatomyositis. There have been 11 cases of primary pure squamous cell carcinoma in the world literature since 1968, but this is the first case report of coexistence of these two diseases.

Carcinoma, Squamous Cell↗
PubMed1980

Induction of precocious melanogenesis of pigment cells in cultures of neuroretinal cells of chick embryo by amphotericin B.

When dissociated neuroretinal cells of the 9-day-old chick embryo were cultured, the cells formed monolayer sheets of somewhat flattened epithelial cells within 15 days after inoculation. During 15 to 30 days, numerous foci of non-pigmented epithelial cells were formed. During 30 to 50 days, melanin appeared in the cells of these foci. When amphotericin B (1 microgram/ml) was added to the culture medium on day 25 of culture, brown pigments appeared precociously, i.e. within the first two days, in the cells. The brown pigments were identified as melanins by histochemical and electron-microscopic methods. Induction of melanogenesis required continuous treatment with amphotericin B. With the precocious appearance of melanins, tyrosinase activity increased rapidly. This rapid increase in tyrosinase activity was inhibited by the addition of phenylthiourea or diethyl-dithiocarbamate. It was not enhanced by iodoacetamide, but was blocked by a low concentration of cycloheximide or actinomycin D. These findings indicate that amphotericin B induces de novo synthesis of tyrosinase rather than activation of pre-existing tyrosinase.

Amphotericin B↗
PubMed1980

The differentiation of leaf frog melanophores in culture.

During early larval development of mexican leaf frog, Pachymedusa dacnicolor, dermal melanophores are typically black, but a few brown melanophores appear about stage 18. During metamorphic climax brown melanophores begin to dominate and by stage 23 they are the exclusive type. The synthesis of the pigment, a red pteridine-dimer, occurred in the melanophores of organ-cultured back skin isolated from tadpoles. The development of this pigmentation in organ culture was independent of thyroxine at least after the onset of metamorphic climax (stage 19). Isolated melanophores in cell culture conditions proliferated only in the presence of MSH, but even these proliferating melanophores, if derived from larvae of stage 21 or younger, showed no indication of pterorhodin synthesis. Melanophores derived from a stage 22 larva and cultured for 18 days synthesized and deposited pterorhodin.

Animals↗
PubMed1980

Plasma cyclic nucleotide responses to insulin-induced hypoglycaemia and methacholine in patients with hyperthyroidism.

The effect of insulin-induced hypoglycaemia and methacholine on plasma cAMP and cGMP levels was studied in normal volunteers, hyperthyroid and hypothyroid patients. A significant positive correlation existed between the maximal increase in plasma cAMP and the maximal decrease in plasma glucose in normals during insulin-induced hypoglycaemia. Therefore, the plasma cAMP response is considered to be dependent on the degree of hypoglycaemia, rather than the dose of insulin. The cAMP response to hypoglycaemia was significantly higher in hyperthyroid patient, and was lower in patients with hypothyroidism than in normals. The cAMP response of the hyperthyroid patients was normalized when their hyperthyroidism was controlled after 3 months of treatment. The plasma level of cGMP was slightly elevated during hypoglycaemia, but there was no significant difference between controls and hyperthyroid patients. The cGMP response to methacholine, which is probably mediated by cholinergic receptors, was significantly potentiated in hyperthyroid patients. The cAMP response, which is presumably dependent on endogenous catecholamines secreted during methacholine-induced hypotension, was also enhanced in hyperthyroid patients. It is likely that beta-adrenergic receptor responses and cholinergic receptor responses are both enhanced in hyperthyroidism.

Adolescent↗
PubMed1980

Effect of chlorpromazine administration on enzyme activity concerning phosphatidic acid metabolism in rat liver.

The effect of chlorpromazine on phospholipid metabolism was studied in rat liver endoplasmic reticulum. Administration of chlorpromazine per os caused a marked increase in microsomal phospholipid content without affecting its composition. The rate of incorporation of both [(32)P]orthophosphate and [2-(3)H)glycerol into phosphatidic acid and phosphatidylinositol increased by the administration of chlorpromazine. Enhanced labeling of phosphatidylinositol was also observed when myo-[2-(3)H]inositol was used as a precursor. The activity of glycerophosphate acyltransferase significantly increased and that of phosphatidate phosphohydrolase markedly decreased by the administration of chlorpromazine. The activity of phosphatidate cytidylyltransferase was not affected by the drug treatment. These findings suggested that the administration of chlorpromazine increases the availability of phosphatidic acid by activating glycerophosphate acyltransferase and inhibiting phosphatidate phosphohydrolase, leading to enhanced synthesis of phosphatidylinositol.

Animals↗
PubMed1979

Clinical application of breath analysis for dimethyl sulfide following ingestion of DL-methionine.

After overnight-fasting, the concentration of dimethyl sulfide in expired alveolar gas (alv-DMS) was determined serially following ingestion of 2 g of DL-methionine in normal subjects and patients with liver diseases. Alv-DMS rose to a peak in 30 to 90 min, declined markedly within 3 h, and then decreased gradually. Half-disappearance times (T 1/2) (mean +/- S.E. min) in each experimental group were: normal (N = 9) 61.7 +/- 4.7, acute hepatitis (N = 6) 62.5 +/- 6.8, chronic hepatitis (N = 10) 84.0 +/- 13.0, and liver cirrhosis (N = 13) 159.2 +/- 30.4, respectively. Cirrhotics had a T 1/2 significantly longer than that of the other three groups: vs. normal P less than 0.02, vs. acute hepatitis P less than 0.05, and vs. chronic hepatitis P less than 0.05. T 1/2 of alv-DMS following ingestion of DL-methionine seems to be of clinical interest.

Breath Tests↗