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Biomedical subjects

H Ibsen

Publications and source records attributed to H Ibsen.

At least 127 records · Page 7Linked to original sources
PubMed1976

Changes in the ratio of plasma to intersitiial fluid volume during long-term antihypertensive therapy.

Based on determinations of plasma (T-1824)(PV) and extracellular fluid volumes (82Br- distribution space) (ECFV), the PV/IF ratio (IF=ECFV.PV) was calculated three times with a 1-week interval between determinations in untreated patients with essential hypertension. During treatment with hydrochlorothiazide (13 males and 8 females), hydrochlorothiazide-triamterne (5 males and 5 females), hydrochlorothiazide-alpha-methyldopa (7 males and 4 females), and propranolol (6 males and 4 females), PV/IF was determined after 2 to 6 months of treatment. PV/IF was significantly reduced during hydrochlorothiazide treatment (delta PV/IF:--0.011, S.D.: 0.011, p is less than 0.001) and propranolol treatment (delta PV/IF:--0.017, S.D.: 0.022, p is less than 0.05), remained unchanged during hydrochlorothiazide-triamterene treatment and increased significantly during hydrochlorothiazide-alpha-methyldopa treatment (deltaPV/IF: .013, S.D.: 0.015, p is less than 0.05). There was a negative correlation between PV/IF and mean blood pressure during hydrochlorothiazide treatment (r:--0.49, n: 21, p is less than 0.05 (and hydrochlorothiazide-triamterene treatment (r:--0.79, n: 10, p is less than 0.01), whereas no correlation was found during treatment with hydrochlorothiazide-alpha-methyldopa or propranolol. Correlation between mean blood pressure and the individual volumes was not observed nor was there any correlation between changes in the parameters investigated. It is concluded that PV/IF is more accurately correlated to mean blood pressure than are the individual volumes and that, during long-term antihypertensive treatment, PV/IF will reflect changes in the tone of the capacitance vessels and the venous resistance vessels, resulting in a changed equilibrium between the intravascular and the interstitial volumes. It is suggested that the reduction in PV/IF during thiazide and propranolol therapy is related to a relative increase in venoconstrictor sympathetic activity whereas the increase in PV/IF by alpha-methyldopa is caused by decreased sympathetic tone and venodilation.

Antihypertensive Agents↗
PubMed1975

Routine exercise ECG three weeks after acute myocardial infarction.

In the third week after acute myocardial infarction, mean 18 days, exercise tests have been performed in 209 patients prior to discharge from the Coronary Care Unit. The exercise was done on a bicycle ergometer with electrically controlled braking, starting at the load 300 kpm/min (equal to 50 W), increasing with 300 kpm/min every 6th min, aiming at a maximal symptom-limited performance. ECG, in 3 extremity leads and 3 precordial leads, and heart rate (HR) were continuously recorded, and blood pressure (BP) was measured every minute. The most common cause for discontinuing exercise was fatigue (in 58%). Anginal pain or dyspnoea was the cause in 23.8%. Only in 9.1% was the exercise interrupted by the investigator because of rhythm disturbances or pronounced ST-T changes. Maximal work varied from 1 min exercise at 300 kpm/min to 6 min at 900 kpm/min (150 W); 18% of all patients were able to work for 6 min at 600 kpm/min (100 W). HR increased on an average from 80 beats/min at rest to 129 beats/min at maximal work load. Systolic blood pressure (SBP) increased on an average from 126 to 170 mmHg. The maximal values reached during exercise were HR 170/min, and SBP 270 mmHg. The product HR X SPB increased a little more than two-fold on an average. ST-T changes indicating myocardial ischaemia during exercise were observed in 70%. During exercise ventricular ectopic beats occurred in 42%. All rhythm disturbances provoked by exercise disappeared spontaneously shortly after work. Persistent ECG changes, reinfarction or other serious complications were not observed in connection with the exercise test. It is concluded that an exercise test under controlled circumstances is safe in patients of all ages in the third week after myocardial infarction. It is an objective measure of physical work capacity and described the reaction to physical activity. It gives a basis for advising return to normal life and is of great psychological importance to the patient.

Acute Disease↗
PubMedDate not supplied

Dermatology life quality index: data from Danish inpatients and outpatients.

The aim of the present study was to provide data on the reliability and validity of a Danish translation of the Dermatology Life Quality Index (DLQI), a short measure of the impact of dermatological diseases on quality of life. The DLQI was administered to 200 outpatients and 100 hospitalized patients suffering from a range of dermatological diseases and to 100 sex- and age-matched healthy controls. Mean scores, internal consistency and test-retest reliability were comparable to the results reported for the original English version. Hospitalized patients reported greater impairment of disease-related quality of life than outpatients, and patients with atopic dermatitis and psoriasis exhibited greater scores than patients suffering from other dermatological diseases. Discriminant, construct and predictive validities of the Danish translation of the DLQI were satisfactory, as indicated by significant associations between DLQI scores and physician-rated disease severity, disease duration and the time patients were willing to spend each day on a hypothetical effective treatment. The results also suggest that the emphasis Danish patients place on various aspects of disability covered by the questionnaire is similar to that of English patients. In conclusion, the Danish translation of the DLQI showed satisfactory reliability and the preliminary results indicate that this version is a valid measure, which can be used in both research and clinical settings.

Adolescent↗
PubMedDate not supplied

Changes in plasma and extracellular fluid volume during long-term treatment with alpha-methyldopa in 11 thiazide-treated patients with essential hypertension.

In eleven patients with essential hypertension, plasma volume (T-1824) (PV), extracellular fluid volume (82Br-distribution space) (ECFV), blood pressure (BP) and the ratio plasma to interstitial fluid volume (PV/IF) have been determined three times before treatment, after more than two months of thiazide treatment and after three and six months of combined thiazide-alpha-methyldopa (AMD) therapy. During combined treatment, PV/IF showed a significant increase, whereas PV and ECFV did not change significantly. Compared to values during thiazide therapy, PV and PV/IF increased, whereas ECFV was unchanged. BP was reduced significantly after thiazide treatment and showed a further significant fall when AMD was added. Based on the results and a review of the literature, it is concluded that AMD acts by interfering with the normal sympathetic activity, thereby producing a reduced venomotor tone and increased venous capacity. The concomitant reduced venous return of blood to the heart is suggested to contribute to the antihypertensive effect of AMD by means of a decreased cardiac output.

Aged↗