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Biomedical subjects

H Hutten

Publications and source records attributed to H Hutten.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Computer-assisted diabetes control].

Blood glucose self-monitoring is essential to stabilize diabetes on a normoglycemic level. But often patients do not find the correct insulin adaptation. Therefore, we developed a computerized system which adapts insulin doses using a control matrix. During a first in-patient period we had a remarkable blood glucose normalization and stabilization.

Adolescent↗
PubMed1985

Controlled study on the use of hand-held insulin dosage computers enabling conversion to and optimizing of meal-related insulin therapy regimens.

We developed a program for a pocket computer (Sharp PC-1500) enabling conversion to and optimizing of meal-related insulin injection regimens. The dosage of regular insulin injected at meal times by a penshaped device (Novo Pen) was calculated in dependence of the carbohydrate content of the ingested meal, daytime, difference of actual and target blood glucose, 4 daily glucose levels of the last 2 or 4 days and physical activity. Long-acting insulin was proposed in dependence of morning blood levels of the preceding days. The response to elevated levels was additionally determined by night values. All quantifications were based on equivalent factors reflecting relations between insulin need and blood glucose changes and carbohydrate intake, respectively. This permits a so-called "quantified adaptation", where all these factors are individually defined and steadily actualized by the computer according to the data processed during adaptation. In a controlled cross-over study 12 type 1 diabetics were treated with conventional therapy (CT = 2-3 injections daily) and computer-assisted meal-related insulin therapy (CAMIT = 3-4 injections daily), each for a 6 weeks period. Although the number of meals was reduced from 6-7 to 3-5 and carbohydrate intake was allowed to vary from day to day, parameters of metabolic control were significantly improved by CAMIT compared to CT: mean blood glucose decreased from 9.10 +/- 2.96 to 6.22 +/- 0.65 mmol/l with CAMIT and only from 8.86 +/- 1.83 to 6.91 +/- 0.90 mmol/l with CT (p less than 0.05) and HbA1 from 10.2 +/- 1.5 to 8.6 +/- 0.8% with CAMIT and only from 9.8 +/- 1.3 to 9.1 +/- 1.0% with CT.(ABSTRACT TRUNCATED AT 250 WORDS)

Blood Glucose↗
PubMed1985

Computer assisted conventional insulin therapy.

Considerable interest has recently been focused on the computer as a new method to improve outpatient treatment of insulin dependent diabetics. Different ways of programming procedures have been proposed to simulate an experienced physician's capability to adjust insulin dosage in a mathematical form. We report here the results of a controlled study with a program for conventional insulin therapy in in- and outpatient treatment. Eleven inpatient type-I-diabetics could be well controlled after 8 days, and 6 outpatient treated type-I-diabetics improved all relevant metabolic parameters after 30 days compared to a control period of the same duration. So, computer assisted therapy promises to be a worthful aid in the treatment of diabetes.

Blood Glucose↗
PubMed1985

Diabetes self-adjustment by a computerized program--first experiences in inpatient and outpatient treatment.

Blood glucose self-monitoring is essential to stabilize diabetes on a normoglycemic level. However, patients often do not find the correct insulin adaptation. Therefore, we developed a computer system to adapt insulin doses using a control matrix. During a first inpatient and outpatient period, we attained a very satisfactory blood glucose normalization and stabilization. During the outpatient period the HbA1c values decreased. Stopping the program in some patients blood glucose levels and HbA1c values increased again.

Blood Glucose↗
PubMed1985

[Flow dynamic studies of artificial tracheal tubes with speech valves].

A system is described for the high-accuracy measurement of the flow resistance of tracheostomy tubes without and with speaking valves during the phase of inspiration with regard to different conditions up to flows of 78 l/min. A microprocessor is employed for the acquisition of the signals and for the presentation of the results by means of a plotter. The results show that the flow resistance of tracheostomy tubes with two speaking valves of different construction in vertical position does not exceed the critical value of 5 mbar.s/l. Lateral tilting does not affect the flow resistance, whereas frontal tilting yields an increase in flow resistance.

Airway Resistance↗
PubMed1980

[Acute changes in intracerebral vascular resistance after application of dihydrogenated ergot alkaloids (author's transl)].

Measurements of total cerebrovascular resistance (CVR) before and after administration of dihydrogenated ergot alkaloids are performed using a decoupling extracorporeal bypass system in rabbits. From the experiments there is clear evidence that the application of dihydroergotoxine-mesylate (28 micrograms/ml intracarotid.) or dihydroergocristine-methansulfonate (Decme, DHEC, 27 micrograms/ml) is followed by a significant drop in total CVR during 5--6 min. In addition, DHEC shows other, more differentiated effects within the cerebrovascular system. At comparable concentrations within the cerebrovascular system, the vasodilatory effect of DHEC seems to be a function of the initial CVR before administration of the drug (range of the initial CVR-values: 1.1--2.0 kPa-min/ml). During very low initial CVR-values (CVR less than 1.1. kPa-min/ml) the application of DHEC is followed by an increase in CVR. There are indications that DHEC acts as a vasoconstrictor in the cerebral vascular bed if the initial CVR-values are quite low. This bivalent effect of DHEC on CVR may cause favourable redistributions of regional blood flow under certain circumstances (e.g., if focal hypoperfusion is combined with perifocal hyperemia).

Animals↗
PubMed1978

[Increased regional hepatic blood circulation and bile flow following application of peloid paraffin packs on rat abdominal wall].

In Sprague-Dawley rats anaesthetized with pentobarbital-Na and breathing spontaneously, regional hepatic blood flow (rHBF) is measured in the liver in situ and during application of peloid paraffin packs on the abdominal wall. Blood flow measurements are performed by means of the 85Kr(beta)-clearance technique after slug injection of the dissolved indicator into the thoracic aorta. Mean arterial blood pressure is monitored continuously. After exposing the liver surface by an incision at the right costal margin, rHBF is measured, 5, 15, 35 and 45 min later. The results of a control series clearly show that there exists a time-dependent decrease of rHBF at comparable M ABP values and normal respiratory gas parameters. If peloid paraffin packs are applied on the abdominal wall 25 min after the surgery, this time-dependent decrease of rHBF ceases and rHBF then increases to initial values. In comparison to the control series the application of peloid paraffin packs on the abdominal wall causes a significant increase in rHBF of about 20--39%. Experiments on bile flow of rats show that under normal conditions and after insertion of a cannula into the common hepatic duct, a time-independent mean flow of 0.053 ml bile/kg body weight/min occurs. The application of peloid paraffin packs 45 min after the suture of the abdominal wall yields a significant increase in bile flow of 18% within 15 min.

Animals↗