Biomedical subjects

H Hunter

Publications and source records attributed to H Hunter.

15 recordsLinked to original sources

PubMed1991

A multicenter evaluation of the A&D TM-2420 ambulatory blood pressure recorder.

The A&D TM-2420 (A&D Engineering, Milpitas, CA) is an automatic, portable, noninvasive blood pressure (BP) recorder which uses a dual microphone system for the detection of Korotkoff sounds. Its accuracy and clinical performance were assessed in a multicenter study that also addressed issues such as observer agreement and the effects of age, arm circumference, heart rate, posture, and blood pressure level on the observer-device differences. We compared 906 simultaneous, same-arm BP measurements in 151 subjects using the TM-2420 versus two skilled clinicians per site using a teaching stethoscope. The agreement between the TM-2420 and mercury column determinations were within 10 mm Hg for 86 to 91% of systolic readings and 91 to 94% of diastolic readings, depending on the posture; a level of agreement which would receive a 'B+' grade from the recent British Hypertension Society guidelines. The limits of agreement (2 standard deviations about the mean difference) for systolic BP between observers and the TM-2420 tended to be greater for the standing position (-20 to 15 mm Hg) compared to supine (-14 to 12 mm Hg) and seated (-13 to 8 mm Hg) positions. Limits of agreement between the observers and device were not dependent upon age, heart rate, arm size, or blood pressure level. Twenty-four-hour blood pressure monitoring in two of the four centers demonstrated an error code rate of 3.4%, excluding 'retries' that are one of the device's features. These data demonstrate an acceptable level of accuracy and performance of the sixth generation of the TM-2420 for use in clinical practice and research.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1985

Comparative efficacy and safety of short-acting and sustained release quinidine in the treatment of patients with ventricular arrhythmias.

A comparative, fixed-dose, parallel, randomized, blinded trial to define the efficacy and safety of a new once-a-day quinidine preparation, Quiniday, at 1200 mg per day, was compared to quinidine sulfate (as Quinora, 300 mg four times daily, and Quinidex Extentabs, 600 mg twice daily) and to quinidine gluconate (as Quinaglute Dura-Tabs, 648 mg twice daily). After placebo washout from all prior antiarrhythmic agents, 76 patients with at least 30 ventricular premature complexes (VPCs)/hr on 48-hour ambulatory monitoring were randomized to 3 weeks of treatment with one of the four study drugs. There was no difference in the etiologic, demographic, New York Heart Association therapeutic classification, or ventricular arrhythmia frequency at baseline between the patients randomized to the four groups. There was no statistically significant difference between the percent efficacy for VPC reduction on any drug compared to baseline or in the percent efficacy of reduction in beats of ventricular tachycardia. There was no difference between the four agents in terms of types of side effects noted nor in their overall prevalence or need for premature discontinuation of therapy. This study demonstrated that a variety of quinidine preparations exist that do not differ in terms of their efficacy or safety, but that a long-acting, once-a-day preparation (Quiniday) was as effective and safe as other forms of quinidine despite its once-a-day dosing schedule. More compliant dosing regimens with effective well-known antiarrhythmic agents are important in the treatment of patients with potentially lethal ventricular arrhythmias, in the hope that sudden cardiac death can be prevented.

Arrhythmias, Cardiac↗

PubMed1983

Megestrol acetate.

Explore the source record for details and available documents.

Adenocarcinoma↗

PubMed1977

XYY males. Some clinical and psychiatric aspects deriving from a survey of 1,811 males in hospitals for the mentally handicapped.

A survey of 1,811 mentally handicapped males in eighteen hospitals is described. Males discovered with supernumerary Y chromosomes numbered 15, of whom 12 were 47,XYY. Some of the physical, social, psychological and psychiatric findings are described and compared with groups matched for IQ and height. The main psychiatric findings are diminished intelligence, retardation in development of secondary sexual characteristics, and poor emotional control leading to inadequate social adaptive patters which are described and discussed.

Absenteeism↗

PubMed1973