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Biomedical subjects

H Humphreys

Publications and source records attributed to H Humphreys.

119 records · Page 7Linked to original sources
PubMed1988

Culture of the organisms and histochemical identification.

The detection of Campylobacter pylori in the upper gastrointestinal tract has important implications for the pathogenesis and treatment of peptic disease. C. pylori is best isolated from biopsies using blood agar or chocolate blood agar incorporating a selective supplement. Plates should be incubated under microaerophilic conditions for five days. A Gram's stain of a biopsy smear provides a more rapid result but the organism may be patchy in its distribution. Of the histochemical methods used, the H & E stain reveals the presence or absence of gastritis and the Warthin-Starry Silver Stain is the most frequently used to detect this organism. The diagnosis of C. pylori infection is now possible in most pathology laboratories.

Bacteriological Techniques↗
PubMed1988

Histological gastritis in duodenal ulcer: relationship to Campylobacter pylori and effect of ulcer therapy.

Antral gastritis has been described in up to 100% of patients with duodenal ulcer disease, and recently has been associated with Campylobacter pylori infection. The present study examines the effect of two ulcer therapies (cimetidine and colloidal bismuth subcitrate) on this lesion. Sixty-four consecutive patients with endoscopically diagnosed duodenal ulcer were randomized to treatment with either agent upon entry into the study. Antral biopsies were taken at both initial and final endoscopies for culture of C. pylori and assessment of degree of gastritis (as based on inflammatory cell infiltrate: grades 0 to 3). The organism was detected in 90% of the patients at initial biopsy, and grades 2 and 3 gastritis were documented in 76%. The presence of the organism and the gastritis were significantly correlated (p less than 0.001), and the bacterium was not cultured from histologically normal antral mucosa. Active chronic gastritis (grade 3) was seen in 65% of those with C. pylori, and was not found in any patient without the bacterium. Cimetidine had no effect on either the organism or the gastritis, whereas the bismuth preparation significantly (p less than 0.002) reduced the prevalence of both. The present study documents that therapy directed against C. pylori has a significant effect on the gastritis of duodenal ulcer disease and possible mechanisms for the observed effects are discussed.

Adult↗
PubMed1987

Problems of comprehensive shared diabetes care.

In its first year 747 diabetics were entered into a comprehensive shared care scheme in which general practitioners agreed to follow up their own patients. After two years patients were recalled to hospital for review through a computer based recall system. Analysis of the first 209 patients reviewed showed that the recall system worked well with failure to trace only eight patients. Six new cases of foot ulcer, 15 of retinopathy, 14 of macular degeneration, and 15 of raised blood pressure requiring treatment were detected at review. Sixty four patients appeared to have had no check on their diabetes during the two years. Of the 117 with written evidence in their cooperation books that they had received some diabetic supervision, many had had no measurement of weight (32), blood pressure (49), or urine (68) or blood glucose (70), and only 55 had had foot and 65 eye examination. This erratic and generally poor standard of supervision suggests that much tighter organisation is required within each practice, with time being set aside specifically for care of diabetics. Practice nurses could have an important role in the delivery and organisation of care.

Comprehensive Health Care↗
PubMed1986

Septicaemia and pleural effusion due to Plesiomonas shigelloides.

Plesiomonas shigelloides is a rare cause of invasive infection, most clinically significant isolates being from the gastrointestinal tract of animals and man. Recently it has been implicated as an increasing cause of opportunistic infections. We report a case of P. shigelloides septicaemia and pleural effusion in a patient with pre-existing alcoholic liver disease. This case serves to illustrate the possible role of P. shigelloides as an opportunistic pathogen in a compromised host especially where there is co-existing liver disease.

Humans↗