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Biomedical subjects

H Honda

Publications and source records attributed to H Honda.

At least 487 records · Page 27Linked to original sources
PubMed1984

CT findings of medulloblastoma.

Computed tomography (CT) of 11 patients with medulloblastoma was evaluated. 6 of them showed solid, nearly homogenous lesions and definite enhancement after infusion of contrast medium. However, 5 cases showed heterogenous mass lesions composed of the areas of low density and iso- or slightly high density which was attenuated by contrast enhancement. Histological examinations revealed that 2 cases had differentiated medulloblastomas, but the other 3 typical medulloblastomas. It should be reminded in the differential diagnosis of cerebellar tumors of pediatric patients that medulloblastoma can reveal heterogenous mass in CT scan.

Cerebellar Neoplasms↗
PubMed1984

[Measurement of the liver and spleen volume by single photon emission computed tomography].

Organ volume was experimentally and clinically determined using single photon emission computed tomography (SPECT). In organ phantom filling with 99mTcO4-, the error was less than 3.3% in the volume over 400 ml but 11% at 200 ml. In 28 cases of patient, liver and spleen volume were measured by SPECT and X-CT. Good correlation was founded between SPECT volume and X-CT volume (r = 0.99, n = 49), although SPECT volume were 16% higher than X-CT volume (y = 1.16 x + 11.6, x: X-CT volume, y: SPECT volume).

Adult↗
PubMed1984

[Combined therapy with microwave hyperthermia and adriamycin in MM2-bearing mice].

C3H/He mice were inoculated i.p. with synergic MM2 tumor cells(2 X 10(6) cells/mouse), and subsequently treated either by systemic hyperthermia induced by microwave irradiation (2450 MHz)alone, administration of ADM alone, or a combination of both. The mice were exposed to hyperthermia for 5 minutes everyday at an output of 10, 20 or 30 watts. ADM was administered i.p. for 3 days at dose levels of 0.025 mg/kg, 0.05 mg/kg or 0.075 mg/kg body weight. The mean survival time and the mean relative body weight were recorded. From these data, tumor-suppressing effects of the treatments were analysed by one-way or two-way variance analysis. Mice treated with 30-watt microwave irradiation survived significantly longer than control mice without treatment (P less than 0.05), as did mice treated with ADM alone (P less than 0.01). The mean relative body weight was similar among the microwave, ADM and control groups. When the mice were given microwave treatment combined with ADM, significant difference was observed in the mean survival time by one-way variance analysis (P less than 0.01), but no significant difference was observed by two-way variance analysis. The best condition of mice and the optimal dose of ADM still remain to be determined to facilitate more efficient tumor-suppression using this combination therapy.

Animals↗
PubMed1984

Cell behaviour in a polygonal cell sheet.

Cell monolayers on culture dishes were divided into two groups: tensile monolayers and non-tensile ones. In the development of an epithelium, a non-tensile cell monolayer turns into a tightly bound tensile one. Detection of these states was carried out by using the boundary shortening procedure, a computer-based geometrical method to show how much the polygonal cell boundary contracts. Non-tensile monolayers were divided further into two groups according to their motility: a fluctuating monolayer in which cells move laterally, and a stable monolayer in which cells are immobilized. Quantitative determination of cell motility was performed by analysing time-lapse cellular patterns. These computer-based geometrical analyses enabled us to divide monolayers into three groups: tensile stable monolayers, non-tensile stable monolayers and fluctuating monolayers, and this study therefore gives an insight into the way in which changing conformations of cells may be assayed.

Animals↗
PubMed1983

Genetic regulation of erythrocyte autoantibody production in New Zealand black mice.

The incidences of positive anti-erythrocyte autoantibodies (AEA) in New Zealand Black (NZB), C57BL/6, their F1, F2 hybrid, and the F1 X NZB backcross mice were 100, 0, 0, 17, and 51%, respectively. This finding is in keeping with the idea that a combined effect of one to three dominant predisposing NZB gene(s) and a single dominant modifying C57BL/6 gene regulates the AEA production. Studies suggested that the modifying locus Aem-1 is loosely linked to Mup-1 locus on chromosome 4, and the gene order is Aem-1: Mup-1: Gpd-1. We analyzed the effects of the Aem-1 locus on other autoimmune traits and found that the gene action of Aem-1 is unrelated to the spontaneous productions of dsDNA-specific antibodies, the retroviral gp70-anti-gp70 immune complexes and natural thymocytotoxic autoantibodies and to the serum level of retroviral gp70. A significant association was observed between the negative AEA and the low (normal) serum IgM level in (C57BL/6 X NZB)F1 X NZB backcross mice. It remains to be determined whether the Aem-1 locus also controls the serum IgM level.

Animals↗