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Biomedical subjects

H Honda

Publications and source records attributed to H Honda.

At least 433 records · Page 24Linked to original sources
PubMed1987

Inflammatory changes in affected muscles of facioscapulohumeral dystrophy.

A 34-year-old man developed slowly progressive muscular wasting of facioscapulohumeral (FSH) distribution with marked asymmetry. Clinical features, family history and laboratory findings were consistent with the diagnosis of FSH dystrophy. However, muscle biopsy revealed an inflammatory reaction with perivascular and endomysial infiltrate, myophagocytosis and invasion of the fibres by mononuclear cells. Monoclonal antibody analysis of the phenotypes of cells in the biopsy specimen suggested that cell-mediated immune response may occur during muscle fibre injury in FSH dystrophy.

Adult↗
PubMed1987

Hyperactivity of Ca channels in vasa deferentia smooth muscle of diabetic rats.

Contractile responses of strips of the prostatic end of vasa deferentia isolated from streptozotocin-treated diabetic rats were investigated with five agonists. Agonists induced similar biphasic responses in vasa deferentia from diabetic and age-matched control rats six to seven weeks after streptozotocin. Twitches were observed superimposed on contractions induced by the adrenergic agonists in strips from most of the diabetic rats. Strips from the diabetic rats developed significantly greater tension than those from the controls. Especially, strips from diabetics had remarkably greater dose-related responses to Ca, and greater Ca influx, than controls when tested in the presence of either KCl or clonidine. The results suggest that both voltage-dependent Ca channels and receptor-operated Ca channels contribute to potentiation of contractile responses in diabetes.

Animals↗
PubMed1987

[Effects of ifenprodil tartrate on erythrocyte deformability and cerebral blood flow].

Effects of ifenprodil tartrate on whole blood filtrability ex vivo in rats was investigated by a standard technique for measuring whole blood filtration time passed through a filter (5 micron). Ifenprodil tartrate was observed to reduce the filtration time dose-responsively. This effect was especially evident at 20 mg/kg (P less than 0.05). On the other hand, no effect on the hematocrit value, plasma concentration of fibrinogen, erythrocyte count or mean cellular volume of erythrocytes was observed. These results indicated the increasing effects ex vivo of ifenprodil tartrate on erythrocyte deformability. The ex vivo effects on erythrocyte deformability was manifested without changing the ATP contents, ATP/ADP ratio or adenylate energy charge in erythrocytes; and a phenothiazine-like amelioration in the shape of crenated erythrocytes was observed. These results suggested that the effect of ifenprodil tartrate on erythrocyte deformability ex vivo might be due to direct action on the erythrocyte membrane. At 0.3 mg/kg, i.v., ifenprodil tartrate significantly (P less than 0.05) increased the blood flow in the hypothalamus of conscious rats. Thus, it was indicated that ifenprodil tartrate, which increases the erythrocyte deformability and the cerebral blood flow, is useful for the therapeutic treatment of cerebrovascular accidents.

Adenine Nucleotides↗
PubMed1987

Effects of ifenprodil glucuronide derivative on platelet aggregation and vasocontraction.

It has been supposed that ifenprodil glucuronide derivative, detectable in large amount in rabbit plasma, is related to the pharmacological actions by ifenprodil tartrate. However, a synthesized ifenprodil glucuronide derivative was found to have no effect on platelet aggregation and vasocontraction in vitro. These results indicate that ifenprodil itself rather than its glucuronide derivative manifested the pharmacological actions.

Animals↗
PubMed1987

The mode of action of ifenprodil tartrate in isolated canine cerebral and femoral arteries.

Tension of isolated rings of cerebral and femoral arteries was measured isometrically and Ca2+ movement in these arteries was measured by 45Ca flux to study the mode of action of ifenprodil tartrate (IFT). IFT (10(-7)-10(-4) M) induced relaxation in basilar and femoral arteries contracted by K+ (50 mM). During normoxia (O2 aeration) it induced contraction in arteries contracted by prostaglandin (PG)F2 alpha (10(-5) M), but induced relaxation during hypoxia (N2 aeration). In K+-induced contraction the relaxed tension induced by IFT was reversed by addition of Ca2+ in a dose-dependent manner. The IFT induced relaxation of femoral arteries contracted by K+ was attenuated in Ca2+-free solution containing 0.1 mM EGTA, and the effect of IFT on basilar and femoral arteries contracted by PGF2 alpha was reversed. IFT inhibited K+-induced Ca2+ uptake in cerebral and femoral arteries. IFT enhanced PGF2 alpha-induced Ca2+ uptake in cerebral arteries under normoxia, but inhibited it under hypoxia. The results suggest that the action of IFT may be due to alteration of Ca2+ utilization by vascular cells through blockade of potential-sensitive channels, and this action may reflect regional differences between arteries.

Adrenergic alpha-Antagonists↗
PubMed1987

[Implantation of a vascular access device in cancer treatment: operation or angiographic technic?].

Thirty cancer patients, who were diagnosed to be beyond the operable stage, were treated by intra-arterial anticancer agent infusion via an implantable vascular access device (VAD) combined with local hyperthermia and/or charcoal hemoperfusion. The VAD was implanted by a surgical procedure in 14 patients, or by a technique similar to super-selective angiography mainly via the femoral artery in the remaining 16 patients who could not be operated on because of their seriously severe clinical condition and/or the difficulty involved in approaching the tumor feeding artery due to the presence of huge tumors or multiple lymph node metastasis. No serious complications were seen in these treatments. However, the catheter became occluded after an average post-implantation period of 9 months in 6 patients in the operative group. Since an operative procedure is very often too invasive for end-stage cancer patients and may enhance tumor growth, VAD implantation utilizing an angiographic technique is recommendable for the treatment of advanced cancer.

Adult↗
PubMed1987

[Continuous intra-arterial infusion chemotherapy by implantable catheter access connected with a continuous infusion pump].

Eleven non-resectable cancer patients have been successfully treated by means of a one-shot and continuous intra-arterial infusion chemotherapy, utilizing an implantable vascular access device (Catheter Access) connected to a continuous infusion pump (Nipro portable syringe infusion pump) via a non-corning needle (Nipro coreless needle set). This result suggests that this simple and inexpensive method can be applied not only for cancer chemotherapy but also for intravenous hyper-alimentation and for treatment of epidural anesthesia.

Aged↗
PubMed1987

Optimal positioning for CT examinations of the skull base. Experimental and clinical studies.

To evaluate the most appropriate CT angles for the skull base, four adult phantom skulls of various shapes were examined by CT. 15 osseous sites in each skull base were selected and the optimum angle for their delineation was determined. Using Reid's base line (0 degree), many sites could be imaged best at angles up to +20 degrees, and +10 degrees was found to be optimum. Examinations of patients using OM-line as a reference disclosed imaging rates in excess of 70% for sites other than the hypoglossal canal, the optic canal and foramen rotundum, which are in horizontal planes.

Adolescent↗