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Biomedical subjects

H Holzmann

Publications and source records attributed to H Holzmann.

At least 127 records · Page 7Linked to original sources
PubMed1984

[Malignant thymoma with polymorphic exanthema and erosive mucous membrane changes].

We report on a 30-year-old female patient with therapy-refractory polymorphous exanthema and widespread erosions in the oral and genital mucosa. The alterations demonstrated in the skin and genital mucosa were associated with a malignant thymoma with metastases being interpretatet as a paraneoplastic syndrome. There was a remarkably large spectrum of circulating antibodies, which had no corresponding clinical correlation. Our examination results indicate a dysregulation between cellular and humoral immunity, obviously caused by the malignant thymoma, with an extraordinary, uncontrolled production of antibodies against structures belonging to the body and alien structures.

Adult↗
PubMed1983

Morphological and functional findings of fixed phagocytes in psoriatics.

Twenty-one psoriatics as well as 24 normal healthy adults were studied by functional bone marrow scintigraphy using Tc-99m-labeled human serum albumin millimicrospheres (Tc-99m-HSA-MM). Functional bone marrow scintigraphy is an in vivo test system for the assessment of various functional properties of fixed phagocytes. Of psoriatics who had no systemic drug treatment, 59% demonstrated peripheral extension of the bone marrow space, indicating hyperplasia of bone marrow phagocytes. This phenomenon could be observed only in one normal subject who was a high-performance sportsman. Of psoriatics treated with aromatic retinoid, 83% (n = 6) demonstrated bone marrow extension, as did 100% (n = 3) of psoriatics with cirrhosis of liver. The "capacity' of bone marrow phagocytes to engulf Tc-99m-HSA-MM ("uptake ratio') was diminished in 34% of nontreated as well as 66% of psoriatics treated with aromatic retinoid. The phagocytic and proteolytic turnover of Tc-99m-HSA-MM in the bone marrow, spleen, and liver was found to e accelerated in 66% of nontreated psoriatics, normal (83%) or accelerated (17%) in psoriatics treated with aromatic retinoid, and considerably delayed in all of the psoriatics with cirrhosis of liver. Functional bone marrow scintigraphy proved to be an appropriate in vivo test system for revealing abnormalities of fixed phagocytes in psoriatics. Furthermore, therapeutic effects as well as the influences of preexisting disorders on different phagocyte populations can be assessed.

Adult↗
PubMed1983

Functional studies of sessile macrophages in liver and spleen of psoriatics.

In 24 psoriatics of either sex aged between 22 and 84 years, functional analysis of sessile macrophages in liver and spleen revealed an accelerated metabolic elimination of Tc-99m labeled human serum albumin millimicrospheres. In psoriatics treated with aromatic retinoid, macrophage activity in liver and spleen was found to be normalized compared to the group of systemically nontreated psoriatics. 3 psoriatics with cirrhosis of the liver demonstrated an unequivocally delayed tracer accumulation in liver and splenic macrophages, the former showing decelerated phagocytosis and proteolysis of ingested albumin particles. The method used allows measuring of phagocytic and proteolytic properties of tissue-fixed macrophages in psoriatics as well as assessing the therapeutic effects of systemically administered drugs on macrophage functions.

Adult↗
PubMed1983

[Modification of endocrinologic parameters by total body UV irradiation].

In 49 healthy test persons we measured various endocrine parameters (ACTH, cortisol, prolactin, triiodothyronine, thyroxine, TSH) prior to and after whole-body irradiation with UV light of varying quality and quantity. 60 min after sunlamp and SUP exposure a marked decrease in the average cortisol plasma level appears which is less than the daily circadian variation. After irradiation with a lamp that mainly emits UVA rays these reactions fail to appear. After sunlamp and SUP irradiation also the concentrations of the thyroid hormones triiodothyronine and thyroxine show a decrease of 22.1 and 13.7%, respectively, which is, however, statistically significant for triiodothyronine only. ACTH and TSH values remain unchanged. According to these results we can conclude that depending on the quality of rays defined endocrinological reactions are caused. Peripheral "consumption" of these hormones and concomitant insufficient central stimulation are suggested.

Adrenocorticotropic Hormone↗
PubMed1983

[Modification of alpha-MSH by UVA irradiation of the skin].

On 40 healthy male volunteers with different pigmentation level (Caucasians: skin types I-III, negroes: skin type VI) the basal alpha-MSH-secretion as well as the influence of UV-A-wholebody-irradiation (6 J/cm2) on alpha-MSH-serum concentration were measured. The mean basic values of red-haired and blondes are with 73,0 respectively 71,6 pg/ml significantly lower than the mean values of negroes with 99,6 pg/ml. After UV-A-irradiation the alpha-MSH mean values within one hour among red-haired persons increase 26,7%, among blondes increase 22,6%. Dark-haired caucasians (skin type III) as well as negroes show no significant changes in alpha-MSH serum level. These results support a peripheral sensor for UV-A-rays which induce a hypothalamic-pituitary response (alpha-MSH secretion) obviously on a nervous way. One can point out that genetic and/or racial characteristics influence this central-nervous reaction due to UV-A-irradiation of the skin. The connection between the development of malignant melanoma and the UV-A-induced changes of alpha-MSH level is discussed.

Adult↗
PubMed1982

[The psoriatic bone manifestation].

Besides the known joint involvement as seen in the whole-body scan which uses 99m technetium-phosphate-complexes, skeletal scintigraphic investigations in 17 patients with psoriasis have demonstrated circumscribed or diffuse accumulative pathological concentrations of the radionuclide within the skeleton of the skull, the thyroid cartilage, the bony thorax and osseous long bones. These pathological accumulations of radionuclides of TcP-complexes which are distant from joint regions, point to proliferative phenomena in the bone in case of psoriasis especially in alterations of the collagenous metabolism.

Adult↗
PubMed1982

[The place of lymphoscintigraphy in the treatment of malignant melanoma of the skin (author's transl)].

Lymphoscintigraphy was performed pre- or postoperatively in 42 patients with malignant melanoma of the skin. The test consisted of the injection of 1.5-2.0 mCi 99mTc-labelled antimony sulphide colloid, both intracutaneously and subcutaneously, either around the primary tumour or along its edges or into the centre of the excision scar or contralaterally. The draining lymph-node groups were scanned with a gamma-camera 4-6 hours after the injection. Except for one patient, the radioactive tracer had always disappeared from the injection site and had accumulated in th regional lymph-nodes. In 11 of 28 patients with melanoma on the trunk, lymphatic drainage was to more than one regional lymph-node group. In most cases with cutaneous melanoma on the trunk, lymphatic drainage could not be anatomically predicted, but easily and unequivocally identified by lymphoscintigraphy. On the other hand, lymphatic drainage of a melanoma of the head or neck, as well as of distal segments of the limbs, almost always followed anatomical expectations. Using lymphoscintigraphic findings, prophylactic lymphadenectomy could be performed selectively in "high risk" melanomas.

Adult↗
PubMed1982

[Skin changes in long-term dialysis patients. clinical study].

Fifty-one regular hemodialysis patients underwent clinicodermatologic examination. Twenty-three of them were on regular hemodialysis for 2-3 years (group I), 28 patients for more than 8 years (group II). Both groups were matched in regard to primary kidney disease, age, and sex. A characteristic feature found was a marked premature aging of the skin, mainly imposing as actinic elastosis. The incidence was related to the duration of hemodialysis (56.5% of patients of the first group and 100% of patients of the second group). There was also a correlation between time on hemodialysis and an increase of skin pigmentation. Other phenomena like xeroderma, decrease of sebaceous and sweat gland secretion, and Raynaud syndrome were also seen more frequently in the second group, but the extent of these alterations was equal in both groups. Seventy-eight percent of the patients of the first group and 43% of the second group suffered from generalized pruritus. Two different froms of pruritus could be observed, one possibly atopic, only occurring during regular hemodialysis, the other occurring independent of hemodialysis. accumulation of rare phenomena like carpal-tunnel syndrome and Dupuytren's contractures in group II together with the frequent occurrence of actinic elastosis implies systemic disturbance of collagen metabolism in long-term regular hemodialysis patients.

Adult↗
PubMed1982

[Hirsuties papillaris vulvae (pseudocondylomata of the vulva)].

Condylomata acuminata-like lesions of the vulva of two sexually mature Turkish sisters are reported. Based on clinical and histological findings the verruciform structures are interpreted as atavistic malformations without functional significance. Their relation to the papillas of corona glans penis are proved in detail.

Adult↗
PubMed1982

[Studies on the percutaneous absorption of benzoyl peroxide (author's transl)].

The percutaneous penetration and the metabolism of benzoyl peroxide (BPO) were assessed in vitro on human skin and in vivo on 5 patients with leg ulcers. The BPO in vitro absorbed by the skin was converted to benzoic acid preferably in the dermis. The portion penetrated through the skin was benzoic acid only. Also in patients treated with BPO, no BPO could be detected in the serum. These findings show that BPO as such is absorbed by the skin, but is systemically absorbed only after the metabolisation to benzoic acid. Therefore a systemic-toxic effect in local therapy with BPO can be excluded.

Benzoyl Peroxide↗
PubMed1981

[Psoriasis and haemodialysis: changes in plasma hormone concentration as a possible therapeutic mechanism (author's transl)].

Free dehydroepiandrosterone (DHEA), DHEA sulphate, testosterone, LH and FSH were measured in plasma from 67 patients with renal disease before and after haemodialysis or haemofiltration. Plasma concentration of the steroid hormones was lower in patients with renal failure than in normal controls, while that of the gonadotrophic hormones was elevated. After haemodialysis or haemofiltration DHEA sulphate level in plasma decreased, free DHEA increased significantly reaching almost the initial value of the control group. There was no change in concentration of the other steroid and gonadotrophic hormones. The likely mechanism is that haemodialysis removes DHEA deficiency in patients with psoriasis which is assumed to be an aetiopathogenetic factor in the disease.

Dehydroepiandrosterone↗
PubMed1981

[Pseudocondylomata of the vulva (author's transl)].

The present casuistry study deals with condylomata acuminata-like lesions of the vulva of two sexually mature 20 and 22 years old Turkish sisters, and a 34 year old Yugoslavian women. Based on clinical and histological particularities the verruciform structures are interpreted as - atavistic? - malformation without functional significance. Their relation to the papillas of corona glans are proved in detail.

Adult↗
PubMed1980

[Glucose assimilation, insulin secretion and insulin sensititivy in psoriasis patients].

The discussion about a connection between diabetes and psoriasis is picked up again. Serum-values of glucose, insulin and C-peptide after intravenous glucose-load and of glucose and C-peptide after intravenous insulin-load were tested. The level of insulin and C-peptide after i. v. glucose-load was found higher in psoriasis-patients (hyperinsulinism). Considering earlier investigations and new results in diabetes-research (incretin concept), a connection between the two diseases must be denied. The carbohydratemetabolism-deviation in psoriasis could be declared by an enteropathy.

C-Peptide↗
PubMed1980

[Radioimmunoassay of dehydroepiandrosterone and 5-androsten-3 beta, 17 beta-diol (author's transl)].

A radioimmunological method is described for the determination of dehydroepiandrosterone and 5-androsten-3 beta, 17 beta-diol in plasma. Interfering cross-reactions of the antiserum of 5-androsten-3 beta, 17 beta-diol with testosterone and pregnenolone make it necessary to separate the steroids by thin-layer chromatography before their final determination. With respect to sensitivity, this method is superior to the commonly used photometric and gas-chromatographic analytical procedures. For both steroids the limits of detection are about 170 fmol.

Androstenediol↗
PubMed1980

[Dehydroepiandrosterone deficiency in psoriasis. Hypothesis on the etiopathogenesis of this disease].

In patients with psoriasis in extra- and intracellular deficiency of dehydroepiandrosterone can be demonstrated which leads to an activation of the pentose-phosphate cycle. This dehydroepiandrosterone deficiency is caused by an increased intracellular activity of 17 beta-hydroxysteroid-dehydrogenase. This results in an increased formation of the reduction product androstendiol, which is unable to inhibit the glucose-6-phosphate dehydrogenase, the keye enzyme of the pentose-phosphate cycle. In addition, a decreased penetration of the steroid through the membrane of erythrocytes is demonstrable, by which the intracellular deficiency of dehydroepiandrosterone is still augmented. The effects of this dehydroepiandrosterone deficiency are changes in the humoral regulation of events in growth and proliferation in patients with psoriasis.

17-Hydroxysteroid Dehydrogenases↗