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Biomedical subjects

H Holtz

Publications and source records attributed to H Holtz.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Absolute arrhythmia without an initially recognizable cause--prognosis and course].

On the basis of a 10-year course examination of 21 patients with absolute arrhythmia (a. p.) should be tested whether it is justified to assume a purely functional cause of disturbances of rhythm in initially normal internal basis findings. In the period of the examinations no patient had died. Five patients showed an organic heart disease without any stronger functional effects (mitral insufficiency, coronary heart disease, hypertension, hypertrophic cardiomyopathy). In two of them complications had appeared (brain embolisms, myocardial infarction). The remaining patients were without any complaints and capable to work, apart from the intermittent or persisting disturbance of rhythm which continued to appear in all cases, and had again normal basis findings. However, in six of them echocardiographical deviations were found. In initially normal basis findings and a.p. at first a good prognosis is to be assumed. Regular control examinations are, however, necessary, that the manifestation of organic basic disease which appears among our patients in 1/4 of the cases is not overseen.

Adult↗
PubMed1985

Contribution to the pathogenesis of essential hypertension: a multivariate analysis of associated factors.

This study attempts to develop a general aetiological concept of essential hypertension by multidimensional investigation of its various risk factors in childhood and adolescence. The investigation is based on married couples and their children (609 parents and their 639 children, a total of 1248 persons), all of them chosen under special aspects. Familial and environmental characteristics of children and young people with hypertension are compared with those of normotensive volunteers of the same age. The multi-dimensionally interacting factors found to be associated with hypertension in children are: hypertension, diabetes and early infarction in relatives of the first or second degree as well as overweight at birth, obesity, nutritional patterns in the earliest and later stages of life, social environment and physical activity of the children and adolescents. The familial factors most likely lead to a predisposition to hypertension while environmental factors may subsequently contribute to its manifestation.

Adolescent↗
PubMed1983

[Effectiveness of different intervention measures in children and adolescents with hypertension and lipid metabolism disorders].

141 children and adolescents (7-21 years, mean age 14.2 years) showed values of blood pressure, total cholesterol and triglycerides greater than or equal to 90 percentile and HDL-cholesterol values less than or equal to 10 during an examination of 639 children of parents with distinct coronary risk factors or early percentile infarction. By randomization they were subdivided into two groups. (A and B) and underwent intervention measures of different intensity. While group B got only a unique recommendation concerning the preventive measures, in group A a regular, non medicamentous individual treatment was performed. After one year a decrease of blood pressure could be proved in the two groups. A significant decrease of total and HDL cholesterol was found only in group A. While the blood pressure was most clearly reduced in 7-13-year-old children, the most distinct lipid changes were shown in 14-17-year-old adolescents. An influence on body-weight and triglycerides could not be established. Our results confirm the possibilities and also the limits of preventive measures in childhood and adolescence. Apart from the intended decrease of blood pressure and total cholesterol the simultaneous decrease of HDL-cholesterol refers to open questions in the conception of the primary prevention, particularly in children.

Adolescent↗
PubMed1982

[The effectiveness of a prevention program for cardiovascular diseases].

In 1968 the addresses of all men of the annual courses of birth 1914-1923 of an Erfurt district were registered (n = 2 023). The aim population was according to accident subdivided into an intervention and a control group. The test persons of the intervention group were repeatedly investigated and participated in a preventive programme. Up to the final investigation in 1977 the control group remained absolutely intact. After about 10 years the intervention population had a statistically significantly lower frequency of infarction and a lower proportion of hypertensive values of blood pressure. In the younger five-year age group the total mortality was tendencially lower (not significant!) than in the adequate control group. There are no differences in the mortality from heart and circulatory diseases and in the distribution of other risk factors between intervention and control groups. A positive effect of the preventive programme was to be proved theoretically as well as empirically, though the decrease of the real incidence of infarction which is to be calculated was by far lower than generally was supposed.

Aged↗
PubMed1982

[Analysis of methods for optimizing lysozyme determination].

In order to optimize the detection of lysozyme in the clinic, studies on photometric and agar diffusion methods were performed with different preparations of micrococcus luteus (lysodeikticus). Living or living lyophilized preparations of micrococcus were suitable. The influence of temperature, test period and lysozyme concentration on the result was demonstrated. The lysoplate technique has several advantages in clinical routine tests, however an exact adjustment of the reagents and the test is necessary (living micrococcus, 3 hours incubation, 50 degrees C test temperature). The lysozyme measurements of different papers are transferable not without reserve and require a careful interpretation in respect of reproducibility and clinical relevance.

Animals↗
PubMed1982

[Optimization of lysozyme determination: comparative study of preparations of test cultures of Micrococcus luteus (M. lysodeikticus Fleming)].

About 6000 single measurements of the susceptibility of different preparations of Micrococcus luteus (M. lysodeikticus Fleming) cells were performed in order to assess their suitability for the determination of various muramidase concentrations. In particular, a turbidimetric method was compared with an agar-diffusion technique under varying experimental conditions. From our results it can be concluded that M. luteus cells washed with ether and acetone or living lyophilized cells are most suitable for turbidimetric determinations of lysozyme activity. The optimum conditions for turbidimetric assays comprised an initial transmission of 20% and a test time of 5 min. For the agar-diffusion technique fresh living or living lyophilized cells were most suitable. For a given incubation time of 3 h an incubation temperature of 50 degrees C yielded the best results.

Acetone↗
PubMed1981

[The natural course of atrial septal defects].

61 patients at the age of 18 to 70 years with untreated atrial septum defect were examined 7.5 to 21 (on the average 10.5) years after the first recognition. Subjective symptomatology, clinical picture, size of the heart, mean pressure of the pulmonary artery and shunt volume at the beginning and at the end of the period of observation were analysed. The results reveal an above all favourable prognosis of the congenital malformation. In a course without complications an age can be reached adequate to the average life-expectance. After the 40th year of age, however, in 75% of the patients complaints appeared or their number increased. With growing age the size of the heart and the frequency of disturbances of the cardiac rhythm increased. In the small left-to right-shunt (less than 30% of the pulmonary flow) in the majority of the cases (85%) the prognosis proved to be good. Even in shunt volumes of more than 60% in half of the patients no essential deterioration developed in the period of observation. No clear relations were found between the mean pressure of the pulmonary artery and the clinical degree of severity. The indication to the operative correction of the atrial septum defect diagnosed only at the adult age demands a critical individual judgement, in which case apart from the haemodynamic parameters anamnesis and clinical findings within a cardiological observation of the course are of particular importance.

Adolescent↗
PubMed1980

[Average time prognosis of hypertension in qualitatively different treatment protocols].

In 1969 within pilot studies in an Erfurt district altogether 254 patients with definitive hypertension as well as 208 patients with borderline hypertension of the male age groups from 1914 to 1923 were recognized. 135 test persons with definitive hypertension (RR--160/95 Torr) were treated antihypertensively within a clinical and ambulatory preventive programme for 8 years and compared with a control group of the same age (119 males of 45-54 years) concerning the presence of possible complications of hypertension, which was treated with unsatisfactory results. By a strict, permanently normotensive decrease of blood pressure--as pharmacotherapy above all the beta-receptor blocker propranolol alone or in the approved combination therapy with dihydralazine and/or hydrochlorothiazide was used--in connection with suitable measures for the intervention of other individual factors with effect on heart and circulation the risk of complications in definitive hypertension could be reduced. Taking into consideration the own long-term observations the necessity of a possibly early beginning medicamentous, antihypertensive permanent therapy of hypertension is without doubt, in borderline hypertension, however, it still remains actual subject of the discussion.

Aged↗
PubMed1979

[The correlation of blood pressure, cholesterol and triglyceride concentration with the administration of hormonal contraceptives in women from 2 Erfurt large-scale plants].

Within the framework of medical check-ups of heart and circulatory system 1,296 women at the age from 15 to 49 years were examined in two Erfurt large plants. Women with hormonal contraception in the age groups 30-34, 35-39 and 45-49 showed statistically significantly higher mean values of the systolic blood pressure than women without oral contraception. In the same way the difference of the cholesterol mean value of 15.3 mg/100 ml and 11 mg/100 ml depending on the intake of ovulation inhibitors could be statistically ascertained in women at the age of 20-24 and 30-34 years. Women with hormonal contraception have statistically significantly higher triglyceride mean value in the age group 15-24 and 35-44 years than the women without oral contraception.

Adolescent↗
PubMed1977

[Cardiovascular preventive medical check-ups in the large industrial plants of Erfurt. 1. Implementation of the screening phase].

During a medical check-up for the recognition and treatment of patients with diseases of heart and circulation or their early stages and of patients with factors of risk in two large factories of Erfurt altogether 6,646 men and women were examined. The screening was carried out in November 1975 and 1976 in immediate nearness of the working place. The times during which could not be worked were thus reduced to a minimum. Some organisational problems and their solutions in the preparation and performance of the screening phase as well as first results are reported on.

Cardiovascular Diseases↗
PubMed1976

[The effect of an ambulatory long term training on performance, metabolic and coagulation parameters after myocardial infarct].

It is reported on the results of a training treatment for outpatients after myocardial infarction which was carried out twice a week during one and a half year, compared to a control group without physical conditioning. Out of 30 patients 14 continuously took part in the training lessons. In contrast to the control group in the training group a clear increase of the working capacity, a slight decrease of the body-weight, of the blood pressure in rest and of the triglycerides in the serum as well as a favourable influence on the glucose tolerance could be proved. The serum cholesterol level and the coagulation parameters did not change significantly. One patient of the training group and one of the control group died. One patient of the training group and one patient of the control group suffered a reinfarction.

Blood Coagulation↗
PubMed1975

[Comparison of various screening methods for the diagnosis of chronic ischemic heart disease].

The screening phase of a multifactorial intervention study which is carried out under the direction of the WHO and the aim of which is the influence on mild forms of hypertension, hypercholesterolaemia and slightly disturbed glucose tolerance was supplemented by an electrocardiogram after work under the conditions of screening. The questionnaire contained in the investigation program for the statistical establishment of a typical angina pectoris after work according to Rose and the modified electrocardiographic test after work were tested concerning their evidence in the early recognition of a coronary sclerosis. As reference test served the Watt-step-test recommended by a group of experts of the WHO. An extensive correlation between screening after work and Watt-step-test was found. Questionnaire according to Rose and gradual load, however, had a smaller correspondence. The result of other investigations was that the distribution of the factors of risk does not give any clear reference to the existence of a latent coronary insufficiency.

Angiography↗