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Biomedical subjects

H Holst-Larsen

Publications and source records attributed to H Holst-Larsen.

10 recordsLinked to original sources
PubMed1990

[Severe, symptomatic hyponatremia].

Severe hyponatremia (serum sodium levels less than 120 mmol/l) is associated with increased morbidity and mortality. We report three cases where patients developed hyponatremia and severe neurological manifestations after medical treatment. The first two patients experienced episodes of general seizures and coma, but recovered in 24 hours without neurologic sequelae after correction of the electrolyte disturbance. The third patient developed the syndrome central pontine myelinolysis with pseudobulbar palsy and quadriparesis. Marked improvement occurred, however, and in three months the patient was almost completely recovered. The development of hyponatremia deserves special attention in connection with the use of diuretics, infusion of sodium-free carbohydrates and immediately after operation.

Adult↗
PubMed1990

[Correction of severe hyponatremia].

Profound hyponatremia is a life-threatening emergency which can result in permanent neurological damage. The rate at which severe hyponatremia should be corrected is the focus of clinical debate. It is important, however, to differentiate chronic from acute hyponatremia and to develop a plan for correcting hyponatremia. A treatment regime is suggested.

Acute Disease↗
PubMed1990

[Jet ventilation].

High frequency jet ventilation gives adequate alveolar ventilation with very small tidal volumes, gas exchange at lower airway pressure, reduced risk of pulmonary barotrauma, and less cardiovascular impairment. Use of small insufflation catheters facilitates surgery when access is restricted, as in laryngeal surgery, and makes it possible to ventilate a patient through a cricithyroid membrane puncture in an emergency situation. In intensive care medicine, jet ventilation can have some advantage over conventional ventilation in patients with bronchopleural fistulas, and when it is difficult to wean patients from a respirator. The article describes experience using an Acutronic AMS-1000 Universal Jet Ventilator.

Adult↗
PubMed1979

Naloxone: a potent ketobemidone antagonist in man.

Naloxone has been accepted as a potent antagonist towards several narcotic analgesics, e.g. morphine, heroin and pethidin. Its effect as an antagonist and its potency against ketobemidone have not been tested in man. We have described the antagonistic effect of naloxone towards the respiratory depression caused by the administration of ketobemidone to patients anesthetized with N2O/O2 and methohexitone.

Adolescent↗
PubMed1976

The hydrolysis of suxamethonium in human blood.

In 30 patients, after induction of anaesthesia, the ulnar nerve on both arms was stimulated, and the resulting had contractions recorded or closely observed. Immediately after the circulation to one arm had been occluded with a tourniquet, suxamethonium 1 mg/kg was injected i.v. The occlusion was relieved after 1, 2 or 3 min. It was found that the duration of block on the occluded arm represented 68, 48 and 19% of the non-occluded arm after 1, 2 and 3 min occlusion respectively. Thus a considerable recirculation of the drug occurs, even 3 min after injection. It can be calculated that the disappearance of suxamethonium from blood is 7.7 mg/litre in the 1st min and 2.9 mg/litre in both the 2nd and the 3rd min. These disappearance rates include both hydrolysis and diffusion from plasma. Thus the rate for hydrolysis contrasts sharply with the published values for suxamethonium hydrolysis in vitro.

Arm↗