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Biomedical subjects

H Hoffmann

Publications and source records attributed to H Hoffmann.

436 records · Page 25Linked to original sources
PubMedDate not supplied

Pharmacokinetic characteristics of the new veterinary antibiotic turimycin.

A macrolide antibiotic turimycin, is a fermentation product of Streptomyces hygroscopicus. It is active in vitro against a range of mycoplasma species and gram-positive bacteria. The antimicrobial activity of the agent was determined in serum, urine, feces and extracts of different organs. In rats, dogs and pigs the serum half life of turimycin ranged from 30 to 120 min. The absorption rate from the intestine was about 30%. After a single iv injection of turimycin into rats, the original substance and its metabolites were excreted preferably by the bile. After oral administration of turimycin to pigs (250 mg/kg daily for 14 days) and to flow (650 mg/kg daily for 10 days) antimicrobial activity was detected in fatty tissue and bile up to the 14th posttreatment day. The pharmacokinetic properties of turimycin are similar to those of corresponding macrolide antibiotics, including tylosin.

Animal Diseases↗
PubMedDate not supplied

Toxicological studies on the new veterinary antibiotic turimycin.

The acute toxicity of turimycin investigated in several animal species and following different routes of administration is low. In mice the LD50 values range from 320 mk/kg after iv injection up to more than 3000 mg/kg when administered orally. When lethal or sublethal doses of turimycin were given, animals either developed clonic convulsions and died within 24 hr, or recovered completely. The main pharmacological effect of turimycin is a reversible, dose dependent decrease in the blood pressure after intravenous injection of 10 to 15 mg/kg in cats and dogs. This may be due to the negative inotropic and chronotropic effect on heart muscle (isolated atria of guinea-pigs) and to the spasmolytic effect on the smooth muscle (rat ileum). A temporary decrease of the renal filtration rate after administration of turimycin is probably caused by its influence on the blood pressure. In rats the hexobarbital sleeping time was increased after repeated administration of higher doses of turimycin. In a chronic study on dogs oral doses of 50 and 125 mg/kg of turimycin, given in capsules daily for 12 months, produced no functional or histopathological abnormalities.

Animals↗