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Biomedical subjects

H Hishinuma

Publications and source records attributed to H Hishinuma.

14 recordsLinked to original sources
PubMed1992

Alterations of gluconeogenesis by ischemic renal injury in rats.

This study was designed to determine changes in one metabolic function, gluconeogenesis (GLG), after ischemic renal injury. Tubule suspensions were prepared by collagenase treatment of SD rat kidneys on 1, 3, and 7 days after left renal artery and vein occlusion for 0-90 min and incubated in Krebs-Henseleit buffer with or without 2 mM pyruvate or malate aerobically. Glucose contents were assayed photometrically. On days 1 and 3 after ischemia for longer than 60 min, serum creatinine levels rose significantly. The tendency of increase of GLG was observed on days 1 and 3 after 10-60 min of ischemia. GLG increased significantly on day 1 after 30-min ischemia. On the other hand, GLG decreased significantly on day 1 after 90-min treatment. Morphologic damage was limited to the corticomedullary region on days 1 and 3 after ischemic times of 30 and 60 min. These results suggest that renal GLG is stimulated to supply energy for ATP decrease by ischemia and for further regeneration in extraproximal segments along the nephron.

Acute Kidney Injury↗
PubMed1987

[Outcome of patients in metastatic renal cell carcinoma with or without embolization].

Nineteen cases of metastatic renal cell carcinoma were embolized (embolization group) and 18 cases were not (non-embolization group). The median survival time after nephrectomy for the 14 cases in the embolization group, 23 months, was more favorable than the 11 months obtained for the 13 cases in the non-embolization group. In the case of one organ metastasis, the median survival time was 33 months for 9 cases in the embolization group and 11 months for 10 cases in the non-embolization group, with a remarkable difference in survival time between the two groups. Therefore, the survival rate can be improved by performing nephrectomy after embolization in the case of single organ metastasis. On the other hand, in the case of multiple organ metastasis prolongation of survival time cannot be expected even when embolization is performed with or without nephrectomy.

Adult↗
PubMed1985

[Pancreatic cutaneous fistula as a complication of left nephrectomy].

Intimate anatomical relationship of the pancreas to the left kidney may lead to pancreatic cutaneous fistula as a complication of left nephrectomy. We report 2 cases of pancreatic cutaneous fistulas that developed as a result of surgical trauma to the pancreas during left nephrectomy. The diagnosis was confirmed when amylase in the drainage was increased. Fistulas closed spontaneously by adequate drainage in 55 and 33 days postoperatively.

Adult↗
PubMed1985

[The role of preoperative embolization in renal cell carcinoma].

In 84 cases of renal cell carcinoma, the effect of embolization was assessed by dividing the patients into two groups: those having undergone (42 cases) or not having undergone (42 cases) embolization. A 16% decrease in tumor volume following embolization using an MMC-micro capsule was noted. In patients without metastasis at nephrectomy, a tendency was observed for the incidence of postoperative metastasis to be lower with more favorable survival for the group with embolization than that without. On the other hand, among cases with metastasis at nephrectomy, there were more patients who survived for a longer period in the embolization group.

Carcinoma, Renal Cell↗