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Biomedical subjects

H Hirose

Publications and source records attributed to H Hirose.

At least 343 records · Page 19Linked to original sources
PubMed1987

Effects of restraint and water-immersion stress and insulin on gastric acid secretion in rats.

Effects of restraint and water-immersion stress (RWIS) and of insulin injection on gastric acid secretion were investigated in relation to blood glucose levels and to brain glucose uptake in rats. Venous blood glucose levels (VBG) were significantly increased while arterial blood glucose level (ABG) was slightly increased by RWIS. In contrast, ABG and VBG were significantly decreased by administration of insulin; the decrease in ABG was greater than that in VBG. Glucose uptake into the brain, calculated from the ABG-VBG, was significantly decreased both by RWIS loading and by insulin administration. The uptake of [14C] 2-deoxy-D-glucose [( 14C]-2DG) into the brain was also significantly decreased in RWIS-loaded or insulin-treated rats. Gastric acid output was significantly increased both by RWIS loading and by insulin administration. The increased acid output paralleled the decrease of glucose uptake into the brain in RWIS-loaded and insulin-treated rats. Results suggest that RWIS-induced gastric acid secretion is regulated by brain glucose uptake and that this gastric acid secretion is a hypothalamic neuron-mediated event as is insulin-stimulated gastric acid secretion.

Animals↗
PubMed1987

An improved technique for the closure of ventricular septal defect in ventricular inversion.

An improved technique for the closure of ventricular septal defect associated with ventricular inversion through the anatomically left ventricle is described. The technique consists of placing a patch completely on the anatomically right ventricular side with modified horizontal mattress sutures all around the defect. This technique was applied successfully in 2 patients with no ensuing conduction disturbance. The details of the technique are reported.

Adolescent↗
PubMed1987

Preoperative left ventricular function: minimal requirement for successful late results of valve replacement for aortic regurgitation.

Postoperative survival and left ventricular function were studied in 62 patients who underwent aortic valve replacement for isolated, chronic aortic regurgitation between 1978 and 1985. The average follow-up period was 3.8 years. There were three in-hospital and six late deaths. Five (56%) of the nine postoperative deaths were of cardiac-related causes. The mean 7 year survival rate was 83 +/- 5%. Preoperative left ventricular end-systolic volume index was the most important indicator (p less than 0.001) for subsequent cardiac death. The 6.5 year survival rate was 92 +/- 4% for patients with an end-systolic volume index less than 200 ml/m2 compared with 51 +/- 16% for those whose index was greater than 200 ml/m2. None of the 48 patients with an end-systolic volume index less than 200 ml/m2 died of cardiac-related causes. Twenty-three of the 48 patients with an end-systolic volume index less than 200 ml/m2 (Group 1) and 6 of the 12 patients with a higher index (Group 2) underwent repeat catheterization 26 months postoperatively. Preoperative afterload, assessed by end-systolic wall stress, was elevated in both groups, but decreased postoperatively, becoming identical to the afterload in 20 normal control subjects. Although the preoperative ejection fraction was depressed in both groups, the great majority of patients in Group 1, compared with none in Group 2, exhibited normal ejection fraction postoperatively. Thus, in patients who recently underwent surgery for aortic regurgitation, satisfactory late results in both long-term survival and reversal of left ventricular dysfunction were obtained when the preoperative end-systolic volume index was less than 200 ml/m2.

Adolescent↗
PubMed1987

Localized oral amyloidosis: ultrastructural and immunohistochemical study.

An histopathological, ultrastructural and immunohistochemical study of localized amyloidosis in the floor of mouth of a 58-year-old male in good health is reported. The lesion was composed of nodular deposits of amyloid surrounded by fibroblastic or histiocytic cells, and metaplastic ossification was seen in some deposits. Ultrastructural findings disclosed typical amyloid fibrils with felt-like structure. Closely connected with the amyloid deposits were cells with active histiocytic or fibroblastic appearance. Their cytoplasm contained amyloid fibrils. At the outermost area of the amyloid deposits, bundles of amyloid fibrils projected from these cells into amyloid deposits. Amyloid protein of the present case did not react to any antisera using anti-AA, anti-A lambda, anti-A kappa and anti-prealbumin antisera. It can be assumed that histiocytes or fibroblasts play an important role in local amyloid formation, however, the nature of amyloid fibril protein in the present case is unknown.

Amyloid↗
PubMed1987

Evaluation of coronary revascularization for ischemic heart disease: in the consecutive 200 cases.

The elective simple coronary revascularization in the last consecutive 200 patients were analyzed in this study. Despite of the increase in older patients who have more high risk factors, including low left ventricular ejection fraction (LVEF) and multiple vessel disease, there were no operative deaths in the second 100 patients. The use of calcium antagonist in patients with a history of spastic angina eliminated episodes of spastic angina in the perioperative period. In the late postoperative period, there were no cardiac deaths during the 7-year follow-up period. Angina remained in two of three patients with the patent grafts, who had a history of spastic angina. Hyperlipidemia and diabetes mellitus influenced occlusion of the grafts and progression of atherosclerosis of native coronary arteries and then four of five reoperations. Exercise tolerance in patients, even those with preoperative low LVEF, has been improved although their was some increment of left ventricular end-diastolic pressure during exercise. Patency rate in sequential grafting with saphenous vein grafts or internal mammary artery grafts were 92% in the average follow-up period of 11 months. The increase of flow rate with nitroglycerine and atrial pacing in internal mammary artery grafts (IMAG) were comparable with saphenous vein grafts.

Aged↗
PubMed1987

Effects of valvular surgery on overall and regional lung function in patients with mitral stenosis.

Changes in overall and regional pulmonary function after open heart surgery were studied in 23 patients with mitral stenosis, grouped according to hemodynamic abnormality at cardiac catheterization. In group 1 (pulmonary arterial pressure less than 25 mm Hg), no pulmonary function disorders were detected before or after surgery. In group 2 (pulmonary hypertension with no or slight tricuspid regurgitation) lung volumes increased significantly within normal ranges after surgery. However, group 3 patients (pulmonary hypertension and moderate or severe tricuspid regurgitation, restrictive and obstructive impairment, uneven alveolar ventilation, disturbed diffusing capacity) did not recover after surgery. The regional perfusion distribution by 133Xe, expressed as the upper over lower lung field ratio, showed significant changes after surgery in groups 1 and 2, but no change in group 3. In groups 1 and 2 it seems that lung parenchyma and pulmonary vessels were not greatly damaged, while in group 3 organic changes in the lung occurred.

Adult↗
PubMed1987

Analysis of the effects of the Blalock-Taussig shunt on ventricular function and the prognosis in patients with single ventricle.

Twenty-four patients with single ventricle, six with single left (SLV) and 18 with single right (SRV) ventricle, who received a Blalock-Taussig (BT) shunt at an average age of 3.2 years were studied. Ventricular function was assessed angiographically by end-diastolic volume index (EDVI) and ejection fraction (EF), and attempts were made to measure ventricular mass index (VMI) and VM/EDV. In 14 patients, the preoperative and postoperative results (average 2.4 years after placement of BT shunt) were compared in SLV (n = 5) and SRV (n = 9) groups. The SLV group showed significant increases in EDVI, VMI, and VM/EDV without a significant change in EF. The SRV group showed significant increases in EDVI and VMI, while EF decreased and VM/EDV was unchanged. Late death from congestive heart failure occurred in five patients with SRV. Three patients with atrioventricular valve regurgitation suffered late death. Among the patients with SRV, the late death group had significantly lower preoperative EF and VM/EDV compared with the survivors (n = 13). All of those with a preoperative EF of less than 0.50 and a VM/EDV of less than 0.35 g/ml suffered late death. In summary, patients with SRV appear to fail to develop adaptational hypertrophy to volume loading after the BT shunt procedure, with concomitant depression in ventricular pump function. Also, late cardiac failure seems likely to develop when low EF and VM/EDV are present preoperatively.

Child, Preschool↗
PubMed1987

[Behavior of left ventricular filling after left ventricular aneurysmectomy: evaluation by pulsed Doppler echocardiography].

The pattern of diastolic flow velocity was studied using pulsed Doppler echocardiography to evaluate postoperative left ventricular (LV) diastolic function in patients who underwent left ventricular aneurysmectomy. This study involved 16 patients who experienced ischemic heart disease from January 1985 to April 1986. The patients were categorized in two groups; the aneurysm group comprised by seven patients undergoing aneurysmectomy, and the bypass group which included nine patients undergoing only coronary artery bypass grafting. Pulsed Doppler studies were performed five to 22 days before, and at an average of 12 days after surgery. Preoperative cardiac catheterization and cineangiography were performed and, myocardial infarct size was estimated by the Wagner's method. Using pulsed Doppler echocardiography, LV filling dynamics were assessed by the peak velocity in the rapid filling phase (R), the peak velocity in the atrial contraction phase (A), and the ratio of A to R (A/R ratio) of the mitral flow velocity pattern. All data were average in five consecutive beats. 1. The estimated myocardial infarct size (%MI) in both groups before surgery was 38.5% in the aneurysm group and 32.5% in the bypass group, and there was no significant difference between these groups. 2. The preoperative cardiac index (2.9 in the aneurysm group vs 2.8 1/min/m2 in the bypass group), left ventricular end-diastolic pressure (16.1 vs 17.3 mmHg), and left ventricular ejection fraction (0.43 vs 0.36) were not significantly different between the two groups. 3. The preoperative A/R ratio was 1.5 in the aneurysm group and this was significantly higher than that of the bypass group (1.2).(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗