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Biomedical subjects

H Hirakata

Publications and source records attributed to H Hirakata.

100 records · Page 6Linked to original sources
PubMed1985

Effect of blood pressure on the progression rate of renal impairment in chronic glomerulonephritis.

An effect of high blood pressure on the progression of renal functional deterioration was studied in 23 cases of chronic glomerulonephritis, which showed progressive renal functional impairments during the long-term follow-up period. The slope-of-regression line, which was obtained from the relation between reciprocal serum creatinine concentration (1/Cr) and observation time, was expressed as a progression rate and was evaluated on an association with blood pressure level. The progression rate was found to correlate significantly with the level of diastolic blood pressure (p less than 0.001). It is concluded that the elevation of blood pressure is one of the factors that contribute to the progression of renal functional impairment in chronic glomerulonephritis.

Adult↗
PubMed1984

Worsening of anemia induced by long-term use of captopril in hemodialysis patients.

During long-term captopril administration to hypertensive patients on maintenance hemodialysis, a decrease in hemoglobin, hematocrit, and red blood cell count was observed in 9 out of 12 cases. The maximum decrease in hemoglobin, on the average, was detected after 10.9 months of captopril treatment, when the average decrease was 20.5%. The average daily dose of the drug was 27.6 mg/day throughout the observation period. Mean corpuscular constants, reticulocyte count, serum iron, and total iron-binding capacity did not change significantly. Coombs' test was negative. Neither serum total protein nor body weight changed significantly. Fever, skin rashes, leukopenia, and eosinophilia were not observed. There was no significant correlation between the degree of decrease in hematological indices and the dose of captopril. After discontinuation of captopril administration, anemia improved to pretreatment levels. In 2 of the 3 patients who did not show worsening of anemia, an anabolic steroid was administered in association with captopril. It is suggested that captopril should be used with caution in hemodialysis patients.

Adult↗
PubMed1983

Long-term hemodynamic response to captopril (SQ 14,225) in hypertensive hemodialysis patients.

The long-term effect of treatment with captopril was observed in 7 hypertensive patients on maintenance hemodialysis who had been refractory to combined antihypertensive therapy with propranolol and hydralazine. Captopril showed a potent hypotensive effect in all the subjects throughout the study period of 6 months. The blood-pressure reduction during treatment with captopril was associated with a decrease in total peripheral resistance. Cardiac index increased significantly due to a significant increment in heart rate at the 6th month. Plasma renin activity increased significantly at the 3rd month, whereas it decreased at the 6th month. No significant correlation was observed between the blood-pressure response and the pre-treatment level of plasma renin activity.

Adult↗
PubMed1981

Captopril (SQ 14225) clearance during hemodialysis treatment.

The clearance of Captopril (SQ 14225) was examined in six hemodialysis patients, using a newly developed method for the determination of Captopril in blood. At 30 minutes after the start of hemodialysis, the clearance of Captopril was 80 +/- 14.2 ml/min, whereas that of creatinine was 123.4 +/- 8.8 ml/min and that of BUN was 144.1 +/- 7.2 ml/min. The blood concentration of Captopril was found to be lower when taken in a postprandial state than in a fasting state.

Adult↗
PubMed1979

Gastric involvement in Sjögren's syndrome simulating early gastric carcinoma.

The case of a 42-year-old woman with Sjögren's syndrome accompanied by severe gastric infiltration and interstitial nephritis is reported. Presentation was with finger stiffness, Raynaud's phenomenon and abdominal discomfort. There were endoscopic and radiological features of early cancer, type IIc (depressed type). Resected stomach showed atrophic gastritis with erosion. Histology showed focal to relatively diffuse destruction of the gastric glands with minimal intestinal metaplasia and dense collections of lymphoid cells with occasional germinal centers in the interstitium of the gastric mucosa. Renal biopsy revealed similar severe diffuse interstitial infiltration of lymphoid cells. Distal renal tubular acidosis was confirmed by sodium bicarbonate and ammonium chloride loading test. Satisfactory improvement in xerostomia, keratoconjunctivitis sicca and other laboratory data occurred on prolonged administration of adrenal steroids and cyclophosphamide.

Adult↗
PubMedDate not supplied

Treatment of hepatic encephalopathy by retrograde transcaval coil embolization of an ileal vein-to-right gonadal vein portosystemic shunt.

A 43-year-old non-cirrhotic woman suffered from encephalopathy caused by an extrahepatic portosystemic shunt between the ileal vein and inferior vena cava via the right gonadal vein. Percutaneous transcatheter embolization with stainless steel coils was performed by the retrograde systemic venous approach. Encephalopathy improved dramatically.

Adult↗
PubMedDate not supplied

Blood concentration and urinary excretion of captopril (SQ 14,225) in patients with chronic renal failure.

Blood concentration and urinary excretion of captopril following 50 mg oral administration were determined by high-performance liquid chromatography in normal subjects and patients with chronic renal failure. In normal subjects, the maximum blood concentration of the free form of captopril was obtained within 1 hour and was not detectable after 6 hours; 41% of administered captopril was excreted into the urine as free form and metabolites within 2 hours, and 58% within 6 hours. In chronic renal failure patients with an average serum creatinine of 5.1 mg/dl, the absorption constant (Ka), maximum concentration (Cmax), and area under the blood concentration curve (AUC) were not significantly different from those in the normal subjects, but the elimination constant (Ke) and biological half-life (T1/2) showed a significant delay in the disappearance of captopril from the blood (p less than 0.01 respectively). The cumulative amount of urinary excretion of either free-form captopril or its' metabolites was significantly decreased at 2, 4, and 6 hours in chronic renal failure patients (p less than 0.01 or less, respectively). Impairment of kidney function is suggested to be an important factor in the promotion of blood retention of captopril.

Adult↗
PubMedDate not supplied

A case of cardiac injury and acute renal failure induced by electrical burn.

Reported is a case of electrical burn associated with cardiac injury and acute renal failure in a 21-year-old man. After coming into contact with a high-tension cable, he became drowsy and oliguria developed. Twenty-four hemodialyses were required. Although the ECG findings revealed an inferior wall myocardial infarction, neither cardiac scintigram (201TlCl) nor ultrasonic cardiography revealed any local lesions. In this case the cardiac damage following electrical burn appeared different from true myocardial infarction.

Acute Kidney Injury↗