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Biomedical subjects

H Hennemann

Publications and source records attributed to H Hennemann.

At least 37 records · Page 2Linked to original sources
PubMed1979

Uraemic sympathetic neuropathy after haemodialysis and transplantation.

Autonomic function in patients with uraemia treated conservatively, by haemodialysis, and by transplantation was evaluated by the pupillary reaction to tyramine, the Valsalva manoeuvre and a postural tolerance test. The pupillary reaction to tyramine is diminished in haemodialysis patients compared with control subjects. Renal transplantation improves, but does not correct the pupillary reaction to tyramine. The frequency of the diminished response roughly correlates with the degree of renal insufficiency, with results of a Valsalva manoeuvre, and with postural tolerance tests. Our data show that uraemic autonomic dysfunction is improved by successful renal transplantation, but not by adequate haemodialysis.

Adult↗
PubMed1978

[Transfemoral embolus aspiration from both renal arteries].

In a 50-year-old female patient who had suffered from coronary heart disease for about 3 years, a cerebral embolus resulted in left-sided hemiparesis. Four days later she became anuric. Acute thromboembolis occlusion of the renal arteries was assumed and renal angiography was performed. The angiography showed complete obstruction of the left renal artery and partial obstruction of the right renal artery. Due to the poor general condition of the patient it was not possible to carry out renovascular surgery or streptokinasetherapy. An attempt was therefore made to remove the emboli from the renal arteries by a new technique (transfemoral embolus aspiration). The subsequent angiography showed normal circulation in the right kidney and improved circulation in the left kidney. Ten days of dialysis treatment were required until urine production started again. Death then occurred from other causes. The autopsy confirmed free permeable renal vessels and absence of permanent sequelae in the parenchyma.

Aortography↗
PubMed1977

[The pros and cons of haemoperfusion (author's transl)].

6 patients with severe self-poisoning were treated by charcoal-haemoperfusion in our centre up to now. In four of them (all suffering from sleeping drug overdosage) the treatment was successful. Two patients with intoxications by agrochemicals died in spite of haemoperfusion. Side effects of haemoperfusion were drops of blood pressure and platelet count, depletion of immune bodies, and adsorption of remedies. Up to now, the indication for haemoperfusion has to consider these secondary actions of encapsulated charcoal as inevitable.

Arteries↗
PubMed1976

Diamine oxidase (histaminase) in chronic renal disease and its inhibition in vitro by methylguanidine.

The activity of plasma diamine oxidase (pyridoxal containing amine oxidase, histaminase, DAO), E. C. N. 1. 4. 3. 6., was found to be normal in 14 patients with chronic renal disease of different origins. However, after administration of heparin (200 IU/kg body weight, i.v.), the release of the enzyme into the plasma of the patients was markedly decreased when compared to that found in a group of 8 healthy volunteers. In patients with chronic renal failure the plasma concentration of pyridoxalphosphate, the coenzyme of DAO, was found to be significantly decreased. Furthermore methylguanidine, which is thought to be an important uremic toxin, was shown to be a potent non-competitive inhibitor of DAO in vitro (Ki5 X 10(5) M). The organ concentrations of methylguanidine are thought to correspond with the Ki value detected, as distribution studies using the tritiated toxin revealed organ accumulation up to five times the plasma level. Therefore, the decrease of DAO release after heparin stimulation in patients with chronic renal failure may be explained, in part, by inhibition of the enzyme as well as by a decreased coenzyme level. The results suggest that disturbed histamine metabolism may be involved in the production of some of the clinical symptoms commonly associated with chronic renal failure.

Adolescent↗
PubMed1975

[Hemo and cross dialysis treatment in phalloidin intoxication in the waking rat].

In vitro 14C-Methyl-Phalloidin is found to be well dialysable; in vivo dialysis is less effective. In rats the application of 2 mg/kg Phalloidin i.v. led to death after 106 minutes on the average. Hemodialysis with electrolyte-glucose solution or with plasma protein solution immediately started after Phalloidin injection did not alter the survival time significantly. Only a group of rats which was cross dialysed immediately after intoxication showed a statistically insignificant prolongation of survival time of 16 minutes. The histomorphological findings of the liver were similar in all groups. We found a phalloidinic vacuolisation of the cytoplasm of the lobular periphery, hemorrhagic necrosis and also fatty changes in the periphery of the lobule with small fat droplets and pycnosis of nuclei. Specific Phalloidin effects, too, were found in the liver of both animals used in cross-dialysis, which proves that Phalloidin is dialysable by this method.

Animals↗