[Studies with nitrofurantoin: bacteriological studies with microorganisms causing urinary tract infections].
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Biomedical subjects
Publications and source records attributed to H Hein.
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Exposures to short periods of high temperature (40 to 50 C) in each 24-hr diurnal temperature cycle (average temperature ca. 25 C) reduced growth of Aspergillus parasiticus and production and accumulation of the aflatoxins when compared with cultures held continuously at 25 C. In contrast, diurnal cycles with an average temperature of ca. 25 C but with minima as low as 10 C did not appreciably affect either growth or toxin production. The ratio of production of aflatoxin B to aflatoxin G increased as the maximal temperature was raised but remained essentially unchanged with decreasing minimal temperatures.
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The production or accumulation of aflatoxins in vitro by four isolates on three substrates (acid-delinted cottonseed, shelled Spanish peanut, and rough rice) was studied in relation to temperature in the range of 10 to 40 C. Within the first 10 days after inoculation, the optimal temperature range for aflatoxin production was between 20 and 35 C. Only small amounts of the toxins were produced at 10 and 40 C. Within the optimal temperature range, the time required for toxin production and for significant accumulation decreased as the temperature increased. More aflatoxin G was produced or accumulated in relation to aflatoxin B at low temperatures (within the optimal range), and the G aflatoxins were metabolized more rapidly at the higher temperatures.
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