Biomedical subjects

H Hefter

Publications and source records attributed to H Hefter.

93 records · Page 6Linked to original sources

PubMedDate not supplied

Spontaneous history of asymptomatic internal carotid occlusion.

Forty-nine patients with ICA occlusion, who presented without any neurological signs or symptoms, were prospectively followed for an average of 31.2 months. Eight patients (16%) suffered a stroke during follow-up, of which five were within the vascular territory of the occluded artery--5 patients (10%) developed TIAs 4 of which were ipsilateral to the occluded artery. Non-invasive vascular follow-up did not reveal a progression of extracranial arterial disease in the majority of later symptomatic patients. Twenty-three patients (46.9%) died during follow-up, coexisting coronary artery disease being the major cause of death.

Adult↗

PubMedDate not supplied

Cerebral asymmetry: MR planimetry of the human planum temporale.

A method is described for the imaging and planimetric measurement of the planum temporale (PT) using computer reformations from three-dimensional fast low angle shot magnetic resonance (MR) data. The procedure allows the determination of size and left-right asymmetry of this area on the posterior supratemporal surface, which has been assumed by previous investigators to be a structural correlate of speech lateralization. To establish a consistent method for future studies, special effort was invested in the elaboration of reliable imaging criteria for the borders of the PT. The authors report MR planimetric measurements of the PT in 10 human cadaver brains performed independently and in a "blinded" fashion by two observers. A high degree of interobserver agreement was found, demonstrating the reliability of the MR criteria for PT delineation. The planimetric data correlated with those from subsequent anatomic measurements following section of the same specimens. The left-right ratios of PT size were almost the same with both methods (mean 1.9). Magnetic resonance planimetry of the PT is a noninvasive, reliable, and quantitative procedure to determine gross cerebral asymmetry in the posterior speech area.

Aged↗

PubMedDate not supplied

The diagnostic value of multi-modality evoked potentials in Wilson's disease.

19 patients with a neurological manifestation of Wilson's disease (WD), most of them with long-term disease (> 10 yr), underwent clinical, psychometrical and electrophysiological evaluation in order to test whether there is a correlation of psychometrical and evoked potential (EP) abnormalities with a semiquantitative clinical score ranging from no (0) to severe (3) symptoms. The following EPs were recorded: acoustically evoked event-related (ERPs), somato-sensory (SSEPs), visually (VEPs) and brainstem evoked potentials (BSEPs). Results were compared with the data of an age- and sex-matched control group. 89% of the patients revealed clinical signs of basal ganglia dysfunction, 11% oculomotor or cerebellar symptoms, but none of the individuals had any clinical hint for visual pathway affection. Psychometrically, 100% had mood disturbances without definite intellectual decline. In EP-recordings, 100% showed ERP, 58.0% SSEP and 53% VEP and BSEP abnormalities. VEP and BSEP measurements did not correlate with the clinical score. There was only a weak correlation of SSEP (right-side)- and ERP-amplitude reduction with the clinical total score. The only significant correlation was found between the clinical total score and the time dependent psychometrical tests. Thus, there is a fairly high percentage of subclinical cerebral impairment in Wilson patients with long-term disease detectable by ERP-recordings which do, however, not correlate with the clinical status of the patients.

Adult↗