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Biomedical subjects

H Hedstrand

Publications and source records attributed to H Hedstrand.

At least 55 records · Page 3Linked to original sources
PubMed1976

Serum lipoprotein concentration and composition in healthy 50-year-old men.

The classification of hyperlipoproteinaemias (HLP) is based on arbitrary limits between "normolipidaemia" and "hyperlipidaemia". 92 randomly selected healthy 50-year-old men were studied regarding serum lipoprotein (LP) lipid composition to define limits for "normality". Cholesterol and triglyceride concentrations were determined and the individual ratios between cholesterol and triglycerides were calculated in the ultracentrifugally isolated LP density classes. A significant linear correlation between cholesterol and triglyceride concentrations was found in the very low density lipoproteins (VLDL) and low density lipoproteins (LDL) but not in the high density lipoproteins (HDL). When different percentile limits for LDL cholesterol and VLDL triglycerides were used as cut-off points for "normality" not only the absolute prevalence but also the relative frequency of different types of HLP was influenced. 26 overweight men studied separately showed significantly increased VLDL cholesterol and triglyceride levels with maintenance of the normal ratio cholesterol/triglycerides of this LP class compared with non-obese subjects. Three different kinds of "extra bands" were occasionally seen on agarose electrophoresis: a "double pre-beta" band in whole serum (3%), a "sinking pre-beta" band with density greater than 1.006 (17%) and a "late pre-beta" band in VLDL (22%). While "sinking pre-beta" is identical with Lp (a) LP the "late pre-beta" band probably represents a certain accumulation of "intermediary particles".

Cholesterol↗
PubMed1976

Lipoprotein composition and lipoprotein interrelations in 50-year-old men with hyperlipoproteinaemia.

The serum lipoprotein (LP) composition and LP lipid interrelations were studied in 50-year-old men with different types of hyperlipoproteinaemia (HLP) and in randomly sampled health controls from the same population. The ratio cholesterol/triglycerides in very low density lipoproteins (VLDL)was high in HLP type III. The other types of HLP showed ratios not significantly different from the controls. The low density lipoprotein (LDL) cholesterol concentration was similar in controls, type III and type IV while, by definition, higher values were seen in type II A and II B. All types of HLP showed statistically significantly higher LDL triglycerides than the controls. HLP type II A and II B showed cholesterol/triglyceride ratios in LDL similar to the controls. The corresponding ratio in type IV was lower than in the control subjects but the lowest ratio was seen in type III with a mean value below the 5th percentile of healthy controls. The high density lipoprotein (HDL) cholesterol concentration was decreased in HLP type IV. Apparently elevated HDL triglyceride levels were seen in all types of HLP with the highest mean value in type III. The LP lipid interclass relationships were analysed in the random sample of health men and compared to corresponding relationships in the different types of HLP. Apart from HLP type III and HLP type IV with low LDL cholesterol levels all other types of LP interconversions. Intype IV a significant negative correlation between VLDL concentration and LDL cholesterol concentration and the cholesterol/triglyceride ratio in VLDL. There were no significant correlations between LDL cholesterol concentration and VLDL lipid variables in other types of HLP and normolipidaemia.

Age Factors↗
PubMed1976

Dietary and drug treatment of hyperlipidaemia. A feasibility study in asymptomatic middle-aged men.

83 middle-aged men with different types of hyperlipoproteinaemia were recruited from a health examination survey. They were treated with diet for 3 months and with diet and drugs in combination over a 2-year period (63 men used drugs). The serum lipid reductions after the dietary period were 14% and 27% for serum cholesterol and triglycerides, respectively. After 2 years the corresponding reductions were 21% and 42%, indicating an additional effect of diet and drugs. There was an average body weight reduction of 4.3% during the first 3 months which was maintained over the 2-year period. Special considerations in treating asymptomatic individuals are discussed.

Body Weight↗
PubMed1976

Detection and characterization of hyperlipoproteinaemia in middle-aged men.

Serum lipoprotein (LP) concentrations were determined and LP patterns were classified in 261 middle-aged men, recruited from a health examination survey, with serum lipid values above the 80th percentile of the same population. Individuals with hyperlipoproteinaemia (HLP) and normolipidaemic controls were characterized also regarding family history of cardiovascular disease, socio-economic factors and clinical and laboratory variables. Subjects with HLP type IV-V and IIB were overweight and showed hyperuricaemia and hyperinsulinaemia compared with normolipidaemic controls and subjects with HLP type IIA. The latter showed elevated erythrocyte sedimentation rate. In spite of being overweight, subjects with HLP type III showed normal fasting values of insulin and uric acid in serum and normal early insulin response to intravenous glucose. The glucose tolerance did not differ significantly between the groups. Men with HLP types IV-V had predominantly sedentary occupations, in contrast to those with type IIA. There were significantly more smokers in the groups with HLP type IIB and IV-V than in the control group. Thus, individuals with different types of HLP tend to show different metabolic profiles but also different socioeconomic and clinical patterns, suggesting that exogenous factors are of importance in the expression of the LP abnormalities.

Age Factors↗
PubMed1976

The early serum insulin response to intravenous glucose in patients with decreased glucose tolerance and in subjects with a familial history of diabetes mellitus.

Intravenous glucose tolerance tests with estimations of K values and measurements of serum insulin concentrations at 0, 4, 6, and 8 min after the start of the glucose injection were performed in connection with a health examination survey of middle-aged men. The possible predictive value for later diabetes mellitus of early serum insulin response after intravenous glucose administration was evaluated by studying subjects with a familial history of diabetes mellitus and patients with different degrees of glucose intolerance. The following conclusions were drawn: The early appearance of glucose-stimulated serum insulin should be studied during the first 6 min after start of the glucose injection. The advantage of making calculations for early insulin secretion by including approximate considerations of the fractional removal rate of serum insulin is not apparent. Serum insulin values in patients with decreased glucose tolerance and subjects with a familial history of diabetes mellitus were best characterized by an insulin concentration index (glucose-stimulated early serum insulin concentration divided by basal serum insulin concentration). This index was significantly lower in these groups than in healthy controls.

Diabetes Mellitus↗
PubMed1976

What middle-aged men know of their parents' cause of death and age at death. A comparison between history and death certificate.

Middle-aged men's knowledge of the circumstances of their parents' diseases and death is reliable to such an extent that it can be used when appropriate for therapeutic purposes in familial diseases. This conclusion is based on findings in a health examination survey of 441 middle-aged men in Uppsala, Sweden where the men were asked whether their parents were dead and, if so, the known cause of death and at what age they had died. The information reported was then compared with the official data kept by the authorities. In 87% of cases it was possible to perform such a comparison. The study showed good conformity of the two sources, in general.

Accidents↗
PubMed1975

Epidemiology of renal stones in a middle-aged male population.

The natural history of upper urinary tract stones has been studied retrospectively in 49-50 year-old men in an urban population. The prevalence of stones in 2322 men was found to be 13.7%, with the highest incidence of onset of the disease during fifth decade. Recurrences had occurred in 42% of all cases, the frequency increasing with observation time. On some occasion 23% of the patients had been admitted to hospital and 12.3% had been operated on, 94.5% of all stones passed spontaneously. A family history of kidney stones was significantly more common in stone patients than in healthy controls, and patients with a family history of stones were more prone to early and repeated recurrences. It is suggested that the raised incidence of stone disease in some families may be attributed to environmental rather than genetic factors. This could be of importance for prophylaxis. Analysis of hospital admission rates supported previous findings of a steady rise in stone incidence. The advantages of population studies for comparative analyses are pointed out.

Adolescent↗
PubMed1975

The smoking habits of men with intermittent claudication.

Smoking habits among 54 male patients with intermittent claudication (IC) and 200 healthy 50-year-old men from the same county have been studied. The prevalence of smokers at the age of 50 was 98% among the IC patients against 46% among the healthy controls. The percentage of heavy smokers and the total tobacco consumptiion were not significantly different in the two groups. However, the percentage of smokers who began to smoke before the age of 15 was significantly higher in IC patients than in the healthy group, 28% to 7%.

Adult↗
PubMed1975

A 3-year follow-up of middle-aged men with borderline blood pressure.

Ninety-eight middle-aged men with untreated borderline raised blood pressure (BP) have been reexamined after three years. Twenty-five subjects were considered to be hypertensive, motivating a shorter interval for rescreening. Systolic BP had decreased in 23%, diastolic BP in 46% and both pressures in 15%. Those who developed hypertension had higher systolic BP at the initial examination. A family history of hypertension was more common in this group.

Blood Pressure↗
PubMed1975

Dopamine-beta-hydroxylase and plasma renin activity in twenty hypertensive subjects.

Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of noradrenalin from dopamine, was assayed in the blood plasma of 20 men with primary hypertension. At the same time plasma was taken for measurement of plasma renin activity. Renin release as well as the plasma level of DBH is dependent upon the activity of the sympathetic nervous system, at least to some extent. A possible relationship between the two enzymes was therefore investigated. However, no relationship could be found in this series of 20 hypertensive patients. Another aim was to study the levels of DBH in venous and arterial blood simultaneously. No difference in the DBH level was found in venous and in arterial blood in 11 patients undergoing heart catheterization.

Adult↗
PubMed1975

Statistical analysis of the reproducibility of the intravenous glucose tolerance test and the serum insulin response to this test in the middle-aged men.

The reproducibility of the intravenous glucose tolerance test (IVGTT) and the serum insulin response to this test have been studied in 48 healthy middle-aged men participating in a health screening program. Two tests were done 4-6 weeks apart. The subjects were ambulatory, and no diet prescriptions other than recommendation of an overnight fast were given. Under these circumstances the correlation between the K values of the two tests was low (r equals 0.55), and the equation for linear regression was y equals 0.56 x + 0.61. The intraindividual variation was 21 per cent, expressed as the coefficient of variation. The early increases in glucose-stimulated serum insulin concentrations in the two tests were significantly correlated (r equals 0.87), and this equation for linear regress was y equals 0.81 x + 10. The coefficient of variation intraindividually for this determination was 20 per cent. We conclude that the K values of the IVGTTs must be judged with caution when obtained in ambulatory practice, especially when the result is used for preventive measures and long-term follow-up of asymptomatic individuals.

Clinical Trials as Topic↗
PubMed1975

Dopamine-beta-hydroxylase after treatment with beta-blockers in hypertension.

Dopamine-beta-hydroxylase (DBH) the enzyme responsible for the biosynthesis of noradrenaline from dopamine, was assayed in the blood plasma of 19 cases with hypertension before and during beta-receptor blockade. Propranolol was given to 15 patients and I.C.I. 66,082 (a new cardioselective beta-adrenergic blocker without intrinsic sympathomimetic properties) to 4 patients. - There was no effect by the drugs on the level of plasma DBH activity in spite of a good reduction of the blood pressure.

Atenolol↗