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Biomedical subjects

H Hecht

Publications and source records attributed to H Hecht.

At least 55 records · Page 3Linked to original sources

Integration of local features as a function of global goodness and spacing.

In two experiments, the accuracy with which subjects detected a conjunction of features was examined as a function of the spacing between items and the goodness of the axis along which they were located. In each array, two items were arranged along a vertical, a horizontal, or a diagonal axis. Based on the well-established oblique effect, the vertical and horizontal axes were considered to be good global patterns and the diagonals were considered to be poor. In Experiment 1, the two items in an array could be two horizontal lines, two vertical lines, a vertical and a horizontal line, or a plus sign with one of the single lines. In Experiment 2, a positive- and a negative-diagonal line were used as the individual features, and an "X" was used as the conjunction. The results from Experiment 1 indicated that global goodness influenced only the rate of illusory conjunctions, and not of feature errors. Illusory conjunctions of vertical and horizontal line segments were more likely to occur in vertical and horizontal arrangements. The results from Experiment 2 revealed a reversal of the effect of global goodness on the rate of illusory conjunctions: Illusory conjunctions of negative- and positive-diagonal line segments were more likely to occur in diagonal arrangements. The results of both experiments taken together showed the existence of an important and new factor that influences the likelihood that features of shape will be conjoined: the ease with which line segments conjoin when they are translated along their extent toward each other. In both experiments, greater spacing between items produced more feature-identification errors and fewer feature-integration errors than did less spacing.

Humans↗

Anxiety and depression in a community sample: the influence of comorbidity on social functioning.

The main aim of the present study was to examine whether the well-established association between depression and social dysfunction still remains when effects of a coexistent anxiety disorder are eliminated from the data. As these effects strongly depend on the proportion of depressed subjects suffering simultaneously from an anxiety disorder, we first examined the frequency of mixed and pure depressive disorders and that of pure anxiety disorders (control subjects) in a community sample (n = 483). Using DIS/DSM-III criteria (reference period 6 months), pure anxiety disorders were most frequent (6%), followed by pure depressive disorders (3%) and the coexistence of anxiety and depression (2%). Cases suffering from both disorders were most severely afflicted in terms of psychopathology (persistence of symptoms, comorbidity regarding other mental disorders). At the diagnostic level, the association between depression and social dysfunction was only slightly influenced by effects resulting from comorbidity; at the level of actual symptoms, however, we found that cases suffering simultaneously from severe depression and severe anxiety were significantly more handicapped in their social lives than depressive subjects with only mild anxiety symptoms.

Adult↗

Major depression with and without a coexisting anxiety disorder: social dysfunction, social integration, and personality features.

Twenty-two inpatients with an acute major depression without an additional lifetime DSM-III axis I diagnosis were compared with 20 inpatients suffering from an acute major depression with a coexistent anxiety disorder. The comparisons focused on social dysfunction, social support, and premorbid personality features. Characteristics of provoking life events and chronic conditions of life during the year before the index admission were analyzed exploratively. Major depressives with an anxiety disorder reported a higher number of abnormal premorbid personality traits such as neuroticism and a tendency towards social isolation; they had fewer confidants and lived alone more frequently than pure major depressives. Furthermore, pure major depressives reported more non-illness-related chronic burdening conditions during the year before the onset of depression than did major depressives with an anxiety disorder. However, there were no differences between the patient groups as to social dysfunction. The results point to fewer personal and social resources of the comorbidity group.

Adult↗

[Care of cancer patients from the point of view of general practice].

Data relevant to the management and post-hospital care of cancer patients were collected in six Austrian General Practices. The prevalence of the most frequent malignant diseases was the same as in extensive Austrian statistics. 10% of our patients were in observance at our practices for more than ten years. Diagnosis was attained in 30% by follow-up of relevant symptoms with the means available to the General Practitioner. 43.3% could be considered healed and had no treatment whatever. Patients being treated in an oncologic centre were significantly younger than patients staying with the General Practitioner. Even in doctors highly motivated to personally inform patients about their diagnosis, 29% of patients had, for valid reasons, not been informed. Only two of 36 patients died at home.

Adult↗

Comparison of depressed patients with and without suicide attempts in their past history.

Forty-eight inpatients with the diagnosis of a Brief or Prolonged Depressive Reaction according to ICD-9 who had attempted suicide just before the admission were compared to 24 inpatients with the same diagnosis but no history of previous suicide attempts. The variables investigated included sociodemographic characteristics, family history, life events within the year prior to admission, social functioning, social support, and personality factors. The comparison of these two groups revealed that alcoholism and suicide attempts in first degree relatives, and divorce or separation of the patients' parents predispose for a depressive reaction associated with the suicidal behavior. No differences between the two patient groups were found for personality factors, number and quality of life events in the year before index admission, social functioning, and social support during the last 4 weeks. Due to the small number of patients in both groups the conclusions drawn are preliminary.

Adult↗

Detection of coronary disease patients at high risk for recurrent myocardial infarction by elevated plasma inactive creatine kinase B protein levels.

The diagnostic and prognostic significance of plasma inactive creatine kinase B protein (CK-Bi) levels measured by radioimmunoassay was determined in various ischemic myocardial syndromes. In 120 stable angina patients free of pain at time of blood sampling, mean CK-Bi level was 114 +/- 42 (SD) micrograms-equiv/ml; 195 micrograms-equiv/ml (95% confidence interval) represented upper limit of normal. In seven coronary artery disease (CAD) patients atrial pacing induced ischemia was not associated with increased coronary sinus CK-Bi. Of 201 consecutive patients with suspected acute infarction (AMI), 45 developed ECG criteria of transmural AMI with concomitant increased plasma CK-Bi levels (498 +/- 133, range 372-718 micrograms-equiv/ml). Elevated CK-Bi levels in evolving transmural AMI were detected before raised CK enzyme activity. Elevated plasma CK-Bi levels also occurred in acute pericarditis and in unstable angina. In the 84 patients not developing ECG changes or elevated plasma CK activity, their plasma CK-Bi levels were also normal and no coronary events occurred in the next 6 months. The remaining 55 patients had nontransmural AMI, with 15 also having elevated plasma CK and CK-Bi levels, of whom six developed re-AMI in the next 3 months. In the other 40 nontransmural AMI patients, plasma CK-Bi levels (350 +/- 65 micrograms/equiv/ml, range 228 to 445) increased significantly without associated CK activity rise, and 24 developed re-AMI (three fatal) in the next 6 months. These data suggest that: (1) plasma CK-Bi protein radioimmunoassay measurement provides a sensitive means for detecting myocardial necrosis or inflammation and (2) elevated plasma CK-Bi levels in coronary disease patients during myocardial ischemic pain may afford identification of a CAD clinical subset at high risk of subsequent AMI.

Angina Pectoris↗

Flow murmur associated with partial occlusion of the right pulmonary artery.

An 18-year-old male student presented with a brief history of syncope followed by shortness of breath with exertion, and the development of murmur over the right chest. The symptoms and murmurs were related to a pulmonary embolus which partially occluded the right pulmonary artery and its major branches. The murmur gradually diminished and disappeared when right pulmonary perfusion had almost returned to normal as determined by lung scan. The association of pulmonic flow murmurs and pulmonary emboli is reviewed.

Adolescent↗