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Biomedical subjects

H Heath

Publications and source records attributed to H Heath.

At least 217 records · Page 12Linked to original sources
PubMedDate not supplied

Long-term effects of raloxifene on bone mineral density, bone turnover, and serum lipid levels in early postmenopausal women: three-year data from 2 double-blind, randomized, placebo-controlled trials.

BACKGROUND: In postmenopausal women, raloxifene hydrochloride has favorable effects on bone and lipid metabolism and does not stimulate reproductive tissues. The studies reported herein evaluated the long-term (3-year) effects of raloxifene treatment on bone mineral density (BMD), serum lipid levels, and drug tolerability in healthy postmenopausal women. METHODS: A total of 1145 healthy European and North American postmenopausal women aged 45 through 60 years were enrolled in 2 parallel, double-blind, randomized, placebo-controlled trials of identical design and randomly assigned to receive raloxifene hydrochloride, 30, 60, or 150 mg, or placebo daily; all groups received 400 to 600 mg of elemental calcium. Assessments included measurements for BMD by dual-energy x-ray absorptiometry, markers of bone turnover, and serum lipid levels. RESULTS: Lumbar spine BMD changed from baseline to 36 months as follows: placebo (mean percentage change + SE), -1. 32% +0.22%; raloxifene, 30 mg, 0.71% +0.23%; raloxifene, 60 mg, 1. 28% +0.23%; and raloxifene, 150 mg, 1.20% +0.24%. Comparable BMD changes were observed in the hip and total body. Biochemical markers of bone turnover were suppressed by raloxifene to normal premenopausal ranges through 3 years. Serum low-density lipoprotein cholesterol was reduced 7% to 12% below baseline through 3 years. Study withdrawals due to any reason (37%) and withdrawals due to adverse events (14%) were not different among groups. The only significant adverse effect of therapy was hot flashes (25% in the 60-mg raloxifene group vs 18% in the placebo group); hot flashes were typically reported as mild and were not associated with study withdrawal (1.7% for 60-mg raloxifene vs 2.4% for placebo). CONCLUSIONS: Raloxifene preserves BMD at important skeletal sites, lowers serum low-density lipoprotein cholesterol levels, and has a tolerability profile comparable to placebo. These results indicate a favorable benefit-risk profile of raloxifene for long-term use in healthy postmenopausal women. Arch Intern Med. 2000;160:3444-3450.

Bone Density↗
PubMedDate not supplied

Visual acuity after successful treatment of large macular retinoblastoma.

Recent trends in the treatment of retinoblastoma have favored radiation therapy as opposed to enucleation. A major determining factor in selecting radiation therapy is the possibility of useful posttreatment visual function. While the treatment of nonmacular tumors seems reasonable, little information is available about the posttreatment visual outcome of large posterior pole tumors. We treated 17 patients (20 eyes) with group III-V retinoblastoma and large posterior pole tumors with external beam radiation. Visual acuity after treatment ranged from 5/200 to 20/50. Potential posttreatment visual function was difficult to predict using such pretreatment factors as age at diagnosis, funduscopic appearance, and the number, size, and location of the tumors. Surprising visual function was obtained in some patients with multiple large macular tumors. Follow up ranged from 1 to 8 years. No patient developed metastatic disease; however, four patients required subsequent cataract extraction. This study supports the consideration of radiation therapy as the primary treatment in eyes previously felt to have a poor visual outcome.

Antineoplastic Combined Chemotherapy Protocols↗
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Back to the future.

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Aged↗
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Building bridges.

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Adult↗
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The need for single registration care homes. 2: Divisions and problems.

The first article in this series, published last week, examined the current provision of care for older people in nursing and residential homes. The authors also detailed the RCN proposals in a report in last week's issue. This week, in the second of two articles, the authors discuss the divisions and polarisations which make the two-tier system unworkable for a client group with a wide range of needs.

Aged↗
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Using memories.

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Aged↗