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Biomedical subjects

H Hauck

Publications and source records attributed to H Hauck.

At least 19 recordsLinked to original sources
PubMed1999

Multiple endometrial stromal nodules with sparse cysts and glands in the lung--a nodular variation of endometriosis that may mimic metastases of sarcoma.

We report an unusual case of a nodular variation of pulmonary endometriosis. To our knowledge, there is no previous report on a morphological investigation of this entity. The etiology of this rare condition is still a matter of discussion. The well-circumscribed nodular mass is composed of cells identical to, or closely resembling, those of endometrial stroma containing sparse cysts and glands. Immunohistochemically, the cells showed an extensive co-expression of cytokeratin AE1/AE3 and vimentin and were highly positive for progesterone receptor (PRICA) and estrogen receptor (ERICA). Cells lining the cysts and glands as a monolayer were reactive for Ber-Ep4, cytokeratin Pan and cytokeratin AE1/AE3 and negative to all other markers used including PRICA and ERICA. The differential diagnosis of this entity included fibrous tumor of the pleura and metastatic low-grade-endometrial-stromal-sarcoma. The morphological findings are correlated with immunohistochemical studies and results of cell image analysis. This study details the clinicopathological features of the nodular variation of pulmonary endometriosis.

Adult↗
PubMed1998

Revision of ambient air quality standards for PM?

Recent epidemiologic findings gave rise to new approaches in setting ambient air quality guidelines for particulate matter in various countries. Because of the complexity of this system defined by many parameters like size distribution, chemical composition, geometry, formation, hygroscopy, or concentration the toxicologic base for acute and chronic effects, especially in the low dose range, is not yet adequate for the formulation of air quality guidelines. Open questions as there is existence of a threshold, shape of the dose-response curve, causative models for the mechanisms and health effects outcome in connection with relatively low doses and groups at higher risks are still under discussion at an international level, thus making political decisions very difficult.

Air↗
PubMed1997

[Reduced lung function parameters after physical exertion in Austrian Alps in ozone concentrations below the legal warning limit].

The ambient ozone concentration has increased greatly over the past decades, which may lead to environmental health problems, especially during the summer. WHO guidelines recommend an 8 hour mean value of < or = 60 ppb ozone without health risk. The aim of the present study was to investigate if elevated zone concentrations at moderate altitudes in the Austrian Alps, characteristic of the situation in the summer months, influence pulmonary function after physical exercise. 24 male non-smokers (mean age 26.7 +/- 4 years) were investigated in the Tyrol (Pitztal) at a mean sea level of 2434 m. During a mountain-guide course lasting for 6 days the subjects were physically active all day long. Spirometry was performed in the morning and in the evening after 8 h of exercise. Ozone and PM10 concentrations were measured on site. The ozone 24 hour mean values ranged between 53 and 71 ppb. A mean decrease of 5.3% (p < 0.00001) was measured in forced vital capacity (FVC) and forced expiratory volume (FEV1) at t3,m in immediately after the highest ozone 24 hour mean value had been registered (71 ppb). A clinically relevant decrease of FVC and FEV1 > 10% was observed at t3,m in 35% of the subjects. However, a linear dependence of lung function changes on the ozone 8 hour mean values was demonstrable for all measuring points only in 10% of these subjects. In 90% of the subjects with a decrease of lung function parameters > 10%, this reduction was at least not monocausally linked to ozone.

Adult↗
PubMed1989

Parameters influencing carbon monoxide kinetics.

Carbon monoxide exchange via the lungs can be satisfactorily described by mathematical models. More complex models allow consideration of various parameters influencing this process. Particularly for special situations like for high risk groups or for extreme environments such a model can be used successfully.

Carbon Monoxide↗
PubMed1986

[Effect of serum factors on the intracellular killing of Trichophyton mentagrophytes microconidia by human polymorphonuclear leukocytes].

The rate of intracellular killing of T. mentagrophytes microconidia by polymorphonuclear leucocytes (PMNL) was investigated in 35 patients with anamnestic or actually present tinea infections under various conditions: in autologous serum, in serum of healthy controls, and in heat-inactivated serum. If the PMNL were incubated in serum from "immunologically experienced" persons, we found acceleration of the intracellular killing rate. Differences regarding killing rates were seen in the first hour of incubation (13 +/- 7.7% against 1 +/- 0.8%), becoming even more pronounced after heat-inactivation of the serum. Absorption of the patient's serum with T. mentagrophytes microconidia markedly reduced the rate of intracellular killing during the first hour of incubation, whereas microconidia pre-incubated in patients serum were readily killed even if a negative control serum was present.

Adult↗
PubMed1984

Carbon monoxide uptake and the resulting carboxyhemoglobin in man.

In order to calculate the carboxyhemoglobin concentration in human blood under various circumstances and for particular groups or individuals, the model proposed originally by Coburn and coworkers in a slightly revised form was tested. The relevant breathing parameters were measured as minute averages and used for computation of COHb time course. At the same time blood samples were taken and analysed for carboxyhemoglobin. For four different subjects, various breathing conditions and work rates the average deviation of experimental data from theoretical predictions is 7.4%. Some data are presented graphically. Excellent conformity of all the results indicate, that the model is suitable to show the influence of most physiological and breathing parameters on the dynamics of carbon monoxide uptake.

Adult↗
PubMed1982

[Senear-Usher syndrome: acquired hemophilia caused by the occurrence of a factor VIII inhibitor].

A 25-year-old woman who had suffered from pemphigus for 2 years developed widespread, scalded skin-like lesions after stopping an immunosuppressive treatment. Histological and immunofluorescence studies confirmed the diagnosis of pemphigus erythematosus. Apart from IgG pemphigus antibodies, granular deposits for IgM at the dermoepidermal junction and circulating antinuclear IgM-antibodies could be detected. Despite of restarting an immunosuppressive regime, the patient developed severe hemophilia due to the occurrence of a factor VIII antiglobulin. Its possible immunopathologic basis is discussed.

Adult↗
PubMed1980

[Candida infections in geriatrics-a current problem (author's transl)].

Investigations for candidiasis of the skin and mucous membranes were done in 191 probands over 65 years of age, of whon 187 were occupants of an old people's home and 4 were having in-patient treatment. In the homes being tested Candida infections of the skin and mucous membranes were very numerous (48% and 26% of those investigated) comparable with the epidemics of thrush in premature and newborn units in previous years. Even the localisation of candidiasis was remarkably similar to that in the newborn and infant age groups (Candida mycosis of the external ear and intercrural area, generalised skin candidiasis resembling Leiner's desquamating erythrodermia). The cause of cutaneous candidiasis in old age was in most cases faecal incontinence in chronically bedridden obese patients (intestinal colonisation with C. albicans). Diabetes mellitus, on the other hand, seems to play only a secondary role in the conditions of old people's homes.

Age Factors↗
PubMed1979

Serological diagnosis of Candida albicans-balanitis and -balanoposthitis.

The Candida hemagglutination test (Candida-HA-Test), the complement fixation, Candida immunofluorescent test (Candida-IF-Test) and the agglutination-test were performed in 34 patients suffering from genital candidosis and in 34 healthy controls. The results obtained were: Candida hemagglutination and complement fixation titers are raised to the same extent in patients suffering from Candida albicans-balanoposthitis when soluble polysaccharide antigens are used in both tests. The high titers indicate a great portion of mercaptoethanol susceptible antibodies in those subjects. When compared with controls, the hemagglutination titers are fourfold lower than those of the patients. There is a four-to-sixfold decrease of the hemagglutination titers performed after mercaptoethanol treatment of the sera in the patients. On the other hand, there is only a twofold decrease of hemagglutination titers in the controls. In chronically infected persons the hemagglutination titers are within the normal range or are raised insignificantly. There is only a twofold decrease in HA-titers after treatment of the sera with mercaptoethanol. On the other hand, the agglutination- and the Candida-IF-titers seem to be elevated as a rule in chronically infected. In those patients the gamma G- and the gamma A-titers are significantly raised, too. The results mentioned above are discussed with regard to their clinical significance.

Adult↗