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Biomedical subjects

H Hata

Publications and source records attributed to H Hata.

At least 271 records · Page 15Linked to original sources
PubMed1980

The use of prostaglandin E1 analogue pessaries in patients having first trimester induced abortions.

A new prostaglandin analogue, 16,16-dimethyl=trans-delta 2-PGE1 methyl ester (16 me E1) was used for preoperative cervical dilatation in 23 pregnant women who had abortion induced for socio-economical reasons in the first trimester of pregnancy. A single vaginal pessary containing 1 mg 16 me E1 was inserted into the posterior fornix at 3-hour intervals. Thirteen (56.5 per cent) of the 23 patients had complete abortions and two patients (8.7 percent) had incomplete abortions. In six patients (26.1 per cent) the cervix was dilated to at least 10 mm and the remaining two patients (8.7 per cent) required mechanical dilatation at the time of vacuum evacuation. Apart from mild gastrointestinal symptoms, no serious side effects were noted. It is concluded that the new prostaglandin analogue, 16 me E1, could be used safely and effectively for preoperative dilatation of the cervix before surgical abortion in early pregnancy.

Abortion, Induced↗
PubMed1980

Electrocardiographic Manifestations in Patients with Uterine Myoma.

Electrocardiographic manifestations in 114 patients with uterine myoma were investigated. Classification of electrocardiograhic patterns was based on the Minnesota Code. No reportable electrocardiogram items were recorded in 24 patients (21.2% of the 114 myoma patients. High-amplitude R waves were found in 23 patients (20.4%), depressed ST segments were recorded in 28 patients (24.8%), and abnormal T waves, such as flat or negative T, were noted in 14 patients (12.4%) of the 114 patients with myoma. Some of these items are explainable by anemia due to excessive uterine hemorrhage in myoma patients. However, it could be concluded that all of these electrocardiographic changes are characteristic of anemic patients. Further studies on cardiovascular disturbances in myoma patients will be needed.

Anemia↗
PubMed1980

Trophoblastic disease: analysis of 342 patients.

The registry for trophoblastic disease in Wakayama, Japan was formed and 342 cases were analyzed. The total number of trophoblastic disease was 342 during 6 years (1972-1977). The number of hydatidiform moles, invasive moles, choriocarcinoma and transitional moles was 278 (81.3%), 28 (8.2%), 18 (5.3%) and 12 (3.5%), respectively. The greatest number of hydatidiform moles occurred in the range 25-29 years inclusive. The percentage of patients with hydatidiform moles over 45 years of age was significantly high. The incidence of malignant complications (invasive moles and choriocarcinoma) of hydatidiform moles was 16.5% in 284 molar pregnancies. The frequency of malignant complications was remarkably high in women over 40 years of age. Thus the epidemiologic study of trophoblastic disease might turn up some important data and the importance should be emphasized.

Adolescent↗
PubMed1980

ATP-driven tubule extrusion from axonemes without outer dynein arms of sea-urchin sperm flagella.

We have prepared axonemes without outer dynein arms from sea-urchin (Pseudocentrotus depressus, Hemicentrotus pulcherrimus) sperm flagella by selective solubilization with NaCl. Electron microscopy revealed that the axonemes gradually lost their outer arms in 0.5 M NaCl during 10 min. Such axonemes retained 42.8 +/- 7.3% of their total axonemal ATPase activity and showed C, A, D and B bands in the dynein region of 4% SDS-gel, while a solubilized fraction of the outer arms consisted almost entirely of A band polypeptide. We have succeeded in causing extrusion of the outer doublets from such axonemes by addition of ATP and trypsin. A bundle of outer doublets was sometimes observed to be extruded first from an axoneme and to show bending motion for a while, subsequently followed by a sliding of separate doublets past each other. The speed of the tubule extrusion process was slower and around 60% of that of intact axonemes having both types of arm. These observations indicate that the inner arms have a function equivalent to that of the outer arms, of sliding on adjacent doublets, although the inner arms seem to be constituted from polypeptide(s) different from that of the outer arms.

Adenosine Triphosphatases↗
PubMed1980

In vitro cultivation of Metastrongylus apri.

The 3rd stage larvae of Metastrongylus apri were successfully cultured in vitro to the nearly maturity adult worms which possessed the sperm and immature eggs, though the worms were smaller in size than those grown in vivo. The most excellent medium for the development was relatively simple and consisted of chemically defined NCTC 109 supplemented with 20% calf serum, penicillin (200 unit/ml) and streptomycin (100 micrograms/ml). Standing culture with a larval concentration of 100 to 200 worms per tube containing 2 ml medium and wih a gas phase of 5% CO2 in air at 37 to 28 degrees c was found to be sufficient twice a week using aseptic techniques. Under these conditions a relatively uniform development was obtained, attaining 85 +/- 6.7% of larvae to the 5th stage.

Animals↗
PubMed1979

Eosinophilic meningitis: a suspected case of angiostrongylosis found in Shizuoka Prefecture, Honshu, Japan.

A patient with eosinophilic meningitis in Shizuoka Prefecture, Honshu, Japan had nausea, vomiting and headache on admission; laboratory examinations revealed leukocytosis with eosinophilia. Eight days later neck stiffness appeared. Lumbar puncture showed an increase of the initial pressure in association with eosinophilic pleocytosis in the spinal fluid. The possibility of angiostrongylosis was considered because the patient had eaten raw slugs for 4 years as a remedy for lumbago. Although the serum contained cross-reactive antibodies against Toxocara canis, positive reactions to Angiostrongylus cantonensis antigens were observed in all of the immunological tests made. These observations, together with results of epidemiological studies in Honshu carried out by other investigators, suggest that the present case of eosinophilic meningitis may have been caused by A. cantonensis. One previous case has been reported from Honshu Island, Japan.

Adrenal Cortex Hormones↗
PubMed1978

Conversion of schistosome cercariae to schistosomula in serum-supplemented media, and subsequent culture in vitro.

Both Schistosoma japonicum and S. mansoni cercariae, axenized by washing in NCTC 109, transformed to schistosomula when incubated directed in NCTC 109 containing 2--50% human or 50% rabbit serum at 37 degrees C. The resultant schistosomula were grown in vitro to adults which mated, although the females did not produce eggs. The cercaria-schistosomulum transformation took place at a slower rate in heat inactivated serum than in unheated serum.

Animals↗