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Biomedical subjects

H Handa

Publications and source records attributed to H Handa.

At least 325 records · Page 18Linked to original sources
PubMed1986

[Clinical analysis of immediate postoperative convulsion].

For the prevention and treatment of immediate postoperative convulsion which develops within 24 hours after neurosurgical operation, clinical analysis of consecutive 1293 cases in Kyoto University Hospital was done. Overall incidence was 3.1% and the incidence was highest in supratentorial craniotomy (5.7%). Previous history of convulsion was not contributory. In 77.5% of all cases, the convulsion was developed within 6 hours after operation and focal convulsion was more often than the generalized one. Status epilepticus was often developed. The incidence of convulsion was well correlated to the level of consciousness. Prognosis was not always poor if appropriate treatment was done without delay. CT showed mild degree of hemorrhage or mass effect. Our study suggests the contribution of focal brain damage at the operation to the development of immediate postoperative convulsion. Further study is necessary to elucidate the pathogenesis and to make appropriate plan to treatment.

Brain Neoplasms↗
PubMed1985

Changes in intracranial pressure and epidural pulse waveform following cold injury.

Using anaesthetized spontaneously breathing cats, intracranial pressure (ICP) was monitored for twenty hours following the insult of cold injury; simultaneous recordings were also made of cerebral blood flow (CBF), epidural pulse waveform (EDP-WF), and systemic arterial pressure (SAP). Results could be divided into two groups depending on whether or not ICP exceeded 30 mmHg. In group one, in which marked increase in ICP including occasional episodes of pressure waves were observed, an initial increase in CBF and the changes in EDP-WF from polyphasic to monotonous at about 20 mmHg were characteristic. On the other hand, in group two, ICP never exceeded 30 mmHg, CBF slightly and continuously decreased and EDP-WF was polyphasic throughout the course. There were no significant differences in trends in SAP, in the extent of spread of oedema and in water content of the white matter between both groups. Therefore, the amount of cerebral blood volume (CBV) due to cerebral vasodilatation was considered to account for the further increase in ICP. Moreover, changes in EDP-WF were regarded as a useful indicator in predicting the trends in ICP since these changes could be observed in a relatively lower pressure range prior to a marked increase in ICP.

Animals↗
PubMed1985

Pubertas praecox and hypothalamic hamartoma.

Precocious puberty of cerebral origin is classified into pseudoprecocious puberty and true precocious puberty. Pseudoprecocious puberty is caused by HCG secreting tumours. True precocious puberty is caused by various hypothalamic diseases. Among them, hypothalamic hamartoma is the most common cause. Precocious puberty is caused by elevated blood pituitary gonadotropin concentration, secondary to the elevated hypothalamic LHRH secretion. The hypothalamic hamartoma is not infrequently associated with laughing (gelastic) seizures as well as convulsions. Diagnosis of a hypothalamic hamartoma is easily made by CT. Although the hypothalamic hamartoma is difficult to operate on, the value of surgery is stressed for treatment of precocious puberty. This is also confirmed by recent reports.

Child↗
PubMed1985

Neurinoma of the oculomotor nerve.

A case of intracranial neurinoma with discrete oculomotor nerve palsy and ipsilateral exophthalmos was reported. Review of the literature revealed that oculomotor palsy as the initial symptom may be pathognomonic in the neurinoma originating from the oculomotor nerve.

Cranial Nerve Diseases↗
PubMed1985

Cavernous angioma in the fourth ventricle.

A cavernous angioma in the fourth ventricle of a 47-year-old man is reported. Because of a progressive clinical course and a ring-like enhancement on computed tomography, a brain tumor, rather than a vascular disease, was suspected. The lesion was removed totally and verified histologically as a cavernous angioma.

Brain Neoplasms↗
PubMed1985

Deep Sylvian meningiomas.

A case of deep Sylvian meningioma in a 35-year-old woman was precisely diagnosed preoperatively with the aid of computed tomography and stereoscopic cerebral angiography. On reviewing the literature, it appears to be the first case that has been accurately diagnosed preoperatively and successfully treated by a total excision without serious complication. We report this case in detail together with another, similar case which we had encountered previously.

Adult↗
PubMed1985

Astroblastoma of pure type.

A rare case of astroblastoma of the pure type occurring in the left occipital lobe of a 54-year-old female is reported. The predominant histologic feature was that of perivascular pseudorosettes. The tumor tissues were not stained by the Mallory's phosphotungstic acid-hematoxylin, but the perikarya of some tumor cells were positively stained for the glial fibrillary acidic protein.

Astrocytoma↗
PubMed1985

Hemolysate-induced release of prostaglandinlike substances from the canine cerebral arteries.

The release of prostaglandinlike substances from canine pial arteries that was induced by exposure of the pial arteries to red blood cell hemolysate was estimated by using a superfusion technique for prostaglandin bioassay. The assay organs used were strips of rat stomach for prostaglandin E2- or prostaglandin F2 alpha-like substances, strips of dog coronary artery for prostaglandin I2-like substance, and strips of dog ileum for prostaglandin F2 alpha-like substance. The substances released from the canine pial arteries induced contractions in rat stomach strips and relaxations in canine coronary arterial strips, whereas they did not induce any response in canine ileal strips. The equivalent prostaglandin E2 doses for the contractions of the rat stomach strips and the equivalent prostaglandin I2 doses for the relaxations of the canine coronary arterial strips were 125.2 +/- 19.4 (n = 8) and 59.5 +/- 16.4 (n = 6) pmol/g wet wt +/- SEM, respectively.

Animals↗
PubMed1985

Histologic study of normal rat brain tissue after neodymium-yttrium aluminum garnet laser irradiation. I. Cerebral hemisphere.

We report a histologic study of normal rat brain tissue after neodymium-yttrium aluminum garnet laser irradiation. Morphological changes occurred at a maximum depth of 5 mm after 60-W, 1-second exposure, at a 2-mm distance between the optical fiber tip and the brain surface. Polymorphonuclear leukocyte infiltration into the irradiated area was observed 48 hours after irradiation. After 72 hours, macrophages and fibroblasts appeared; their number increased thereafter. At 1 month, tissue defects attributable to neodymium-yttrium aluminum garnet laser irradiation were small. Gliotic changes were rarely seen. We conclude that 60-W irradiation is harmful to young rats but not to adult rats.

Animals↗
PubMed1985

Histologic changes in rat brain tissue caused by neodymium-yttrium aluminum garnet laser irradiation. II. Cerebellum.

Histologic changes after neodymium-yttrium aluminum garnet laser irradiation were evaluated in the rat cerebellum. Irradiation of 60 W (corresponds to 45.2 W/mm2) to the posterior fossa was dangerous even in adult rats, although this value was safe for the rat cerebral hemisphere as previously reported. The histologic changes caused by neodymium-yttrium aluminum garnet laser irradiation were similar to those caused by thermal energies. To the adult rat cerebellum, 45 W (35.2 W/mm2) can safely be applied. For the further use of the neodymium-yttrium aluminum garnet laser in neurosurgery, our findings should be taken into consideration.

Animals↗
PubMed1985

Transcription of the human adenovirus E1a gene in Saccharomyces cerevisiae.

The early region 1a (E1a) and its flanking sequences of human adenovirus type 5 (Ad5) have been cloned in the yeast-Escherichia coli shuttle vector YEp13 and transferred into the yeast Saccharomyces cerevisiae. The E1a-specific RNAs were produced in the transformed yeast cells. The 5' ends of these transcripts were capped but were lacking 10 to 45 nucleotides from the 5' end of the proper E1a mRNA. These transcripts terminated approx. 1000 nucleotides downstream from the proper 3' end. No splicing of the E1a-specific RNA could be detected in the yeast cells.

Adenoviruses, Human↗
PubMed1985

Brain tissue acidosis and changes of energy metabolism in mild incomplete ischemia--topographical study.

Regional changes of brain tissue pH and its correlation to energy metabolism were studied in various degrees of incomplete ischemia for 5 and 60 min in the unilateral common carotid occlusion of normally fed mongolian gerbils. The degree of ischemia was evaluated by the severity of neurological deficits following 60 min of occlusion, and animals were divided into three groups: symptomatic, borderline, and asymptomatic. Changes of NADH and ATP distribution corresponded well to the degree of ischemia. On the other hand, acidosis developed more clearly and extended in wider areas than the changes of NADH and ATP distribution. These changes were already seen at 5 min of occlusion. From the results of this experiment, it was suspected that acidosis in mild incomplete ischemia was due to stimulated anaerobic glycolysis that might supplement NADH oxidation and ATP yields. Further, acidosis without energy failure was considered not to be detrimental to neuronal cells.

Acidosis↗