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Biomedical subjects

H Hamelmann

Publications and source records attributed to H Hamelmann.

At least 91 records · Page 5Linked to original sources
PubMed1976

Marburg experiment on surgical research: a five-years' experience on the cooperation between clinical and theoretical surgeons.

The organisation of surgical research in Marburg is an experiment which has run for five-years and war carried out in attempt to establish a cooperation between clinical and theoretical surgeons (scientists in basic research). The experiment was started 1970 by creating a Division of Experimental Surgery and Pathological Biochemistry at the Surgery Clinic of the University. Structures and functions in this experiment were 6 small working teams, special services for the teams and for the whole Department of Surgery as well as a training programme in surgical research for theoretical surgeons. Success and failure in the experiment were evaluated by criteria testing three principal functions of surgical research: Training of clinical and theoretical surgeons in methods and techniques of surgical research, performance of controlled clinical trials and basic research in surgery. The early results of the Marburg experiment seem to be promising.

Biology↗
PubMed1976

Acute appendicitis and postoperative fecal fistula: symptoms of an unrecognized carcinoma of the colon.

This report is a retrospective evaluation of 12 case histories. All patients had been subjected to laparotomy on suspicion of acute appendicitis. The operative situations seemed to corroborate clinical expectations: an inflamed ileocecal process was assumed to be a result of performation of a gangrenous appendicitis. In three patients a primary adenocarcinoma arising from the appendiceal base was the incidental histologic finding postoperatively. In three other patients this inflammatory-looking process was related to a cecal carcinoma. In six patients a carcinoma existed unrecognized as the basic disease, these patients being subjected to intra-abdominal drainage only or in connection with appendectomy. In five instances a fecal fistula was the main persisting symptom of postoperative morbidity, in one patient even as long as two years after laparotomy. The problem in diagnostic verification of the initially unidentified carcinoma is illustrated. Attention is directed towards avoiding a false feeling of security in the presence of inflammatory manifestations in the right lower abdominal quadrant, which may misleadingly suggest a ruptured appendix.

Abscess↗
PubMed1976

Histamine release in human subjects by modified gelatin (Haemaccel) and dextran: an explanation for anaphylactoid reactions observed under clinical conditions?

Histamine release by modified gelatin (Haemaccel) and dextran (Macrodex) has been demonstrated in volunteers by direct and indirect methods. In a pilot study of Haemaccel, histamine release was observed in six of seven volunteers. The highest plasma histamine concentration was 4.8 ng/ml, the lowest 1.7 ng/ml: two of the subjects showed slight allergic reactions. Using Haemaccel batch 2551, 10 out of 12 subjects reacted to the rapid infusion of Haemaccel with increased plasma histamine concentrations, whereas none reacted to Ringer's solution. None of the 10 subjects had an allergic reaction, but an increase in gastric secretion was observed in eight. Changes in the venous basophil granulocyte count were found in both those who reacted and those who did not react to Haemaccel. After the rapid infusion of dextran the highest plasma histamine concentration was 5.0 ng/ml, the lowest 1.3 ng/ml. The withdrawal of blood had no influence on plasma histamine concentration. The incidences of histamine release produced by Haemaccel varied with different batches. Thus, it seems unlikely that immunological mechanisms are principally responsible. Nine instances of allergic and anaphylactoid reactions to plasma substitutes have been reported, seven after Haemaccel infusion, and two after dextran administration. One of the patients who received dextran died. Histamine release was always associated with Haemaccel infusion and corresponded in extent to the clinical symptoms observed, but there was no significant histamine release associated with the reactions to dextran.

Adult↗
PubMed1976

[Improved control of the pressure during use of the Sengstaken-Blakemore tube].

For the control of acute hemorrhage from esophageal varices by balloon tamponade a proper application of the Sengstaken-Blakemore tube is necessary to arrest bleeding and to minimize complications. A simple modification of the pressure measurement used up to now is described with other suitable applications. By this modified technique a correct pressure can be kept in the esophageal balloon spontaneously; its ease in handling in intensive care makes for better results in emergency management of balloon-tamponade in treatment of acute bleeding from esophageal varices.

Acute Disease↗
PubMed1975

Studies on the oxygen supply of heterotopic auxiliary liver grafts in rats.

Heterotopic auxiliary liver transplantations were performed in rats using the method of Hess et. al. [6]. Oxygen pressure of liver tissue was measured with a Pt-surface electrode of Kessler and Lübbers [10]. After ligation of the hepatic artery, liver tissue PO2 decreased and remained low during further preparation. Only two of the seven lobes of the rat liver (= 30% of the parenchyma) were used as a graft. After revascularization and application of a gelatine plasma substitute, tissue PO2 of the graft increased to values of normal rat liver, although the graft was supplied with portal blood only. We suggest that one reason for this is the increase of portal perfusion rate, for the whole amount of portal blood perfuses only 30% of liver parenchyma. In the first month after transplantation PO2 of the graft parenchyma was low, but increased continually in the following months, reaching PO2 values of normal rat livers after 1 year.

Animals↗
PubMed1975

[Histamine liberation in man following plasma substitution with gelatine and dextran: cause of anaphylactic reactions in the hospital?].

After rapid gelatin infusion in many cases a release of relatively small amounts of histamine was observed. Clinical symptoms occured in 5 cases in correspondence to the increased histamine levels, but were relatively harmless. The application of dextran 60 induced anaphylactoid reactions in 2 persons, with death in one case. Plasma histamine level were normal in both cases. Histamine release probably is not the cause of dextrn induced anaphylactoid reactions.

Anaphylaxis↗