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Biomedical subjects

H Hamann

Publications and source records attributed to H Hamann.

84 records · Page 5Linked to original sources
PubMed1979

[Reconstructive surgery of the internal carotid artery (author's transl)].

Between 1970 and 1978 we performed 403 endarterectomies of the internal carotid artery on 330 patients. Operative morbidity (and mortality) depended on the severity of the ischemic cerebral damage at the time of the operation: stage I (137 operations):1.5% (0.7%); stage II (134 operations): 2.2% (3.7%); stage III (29 operations): 3.4% (10.3%); stage IV (103 operations): 3.9% (7.8%). According to the life-table analysis (average follow-up: 40 months) the rate of cured or improved patients amounts to 94% (operated at stage I), 85% (stage II), 84% (stage III) and 70% (stage IV).

Arterial Occlusive Diseases↗
PubMed1979

[Expanded PTFE (polytetrafluoroethylene) vascular prostheses--a new path of arterial and venous replacement].

Based on existing experimental and clinical observations the expanded PTFE graft shows convincing advantages in some indication fields (e.g., vascular access for hemodialysis, venous reconstruction) compared with conventional porous prostheses and biografts. On the other hand, we have to realize that expanded PTFE is not yet qualified to be the optimal substitute for small arteries. In spite of encouraging preliminary results, the use of this new type of vascular prosthesis still requires critical evaluation to avoid unpredictable failure due to uncritical surgical optimism (caution: Sparks disaster!). Further improvements may be expected from a better anchorage in the surrounding tissue (e.g., external velour), and from an increase of antithrombogenity of the inner surface.

Arteries↗
PubMed1977

[Injury hazards in deliveries using the Shute forceps (analysis of 1016 forceps deliveries)].

Report about 1016 deliveries by means of the parallel forceps (W. B. Shute). This group contains pathologic-anatomical results of 30 stillbirthes or died newborns. Accordingly to the classification in subarachnoidal, subependymal or subdural hämorrhage there are only in two cases signs of obstetrical brain damage. The hypoxia is the most important reason of intracraniale haemorrhage. In order to an objektive indication, without progredient signs of fetal hypoxia the extraction by means of parallel forceps is not dangerous. We have used the instrument for extraction as well term as preterm infants with good results.

Adult↗
PubMedDate not supplied

Inheritance of guttural pouch tympany in the arabian horse.

The objective of the present study was to analyze the mode of inheritance of guttural pouch tympany (GPT) using pedigrees of Arabian horses. Complex segregation analyses were employed to test for the significance of nongenetic transmission and for monogenic, polygenic, and mixed monogenic-polygenic modes of inheritance. Horses affected by GPT comprised 27 Arabian purebred foals. Of these 27 animals, 22 were patients at the Clinic for Horses, School of Veterinary Medicine Hannover, Hannover, Germany, between 1994 and 2001 and 5 Arabian foals were from stud farms. Information on the pedigrees of these patients allowed us to classify the affected foals into four families with a total of 276 animals. The regressive logistic model analysis took into account the nonrandomness of the pedigrees through multiple single ascertainment correction. The complex segregation analysis showed that, among all other models employed, a polygenic and a mixed monogenic-polygenic model best explained the segregation of Arabian foals with GPT. Models including only nongenetic distributions and monogenic inheritance could be significantly rejected. This is the first report in which a genetic component could be shown to be responsible for GPT in horses.

Analysis of Variance↗
PubMedDate not supplied

Analysis of prevalence of presumed inherited eye diseases in Entlebucher Mountain Dogs.

We analyzed the prevalence of the presumed inherited eye diseases (PIED) noncongenital cataract and progressive retinal atrophy in the Entlebucher Mountain Dog for systematic environmental influences and the additive genetic variation. Multivariate linear animal models using residual maximum likelihood methods and multivariate threshold animal models using Gibbs sampling in Bayesian analyses were used to estimate variance and covariance components. Data were obtained from the kennel club for Swiss Mountain Dog breeds in Germany. PIED were recorded using the standardized protocols of the Dortmunder Kreis, the German panel of the European Eye Scheme for Diagnosis of Inherited Eye Diseases in Animals (DOK). The material included 515 Entlebucher Mountain Dogs from 344 litters at 77 different kennels. Veterinary diagnoses for PIED were from the years 1981-2001. Pedigree information was available for up to nine generations. The multivariate animal model regarded the fixed effects of sex, birth year, experience of the veterinary ophthalmologist, litter size, percentage of examined dogs per litter, inbreeding coefficient and age at examination. The common environment of the litter and the additive genetic effect of the animal were taken into account as randomly distributed effects. The heritability estimates for PIED in the Entlebucher Mountain Dog were h2=0.15+/-0.06 (noncongenital cataract), and h2=0.34+/-0.08 (progressive retinal atrophy) in the linear model and h2=0.32+/-0.05 (noncongenital cataract) and h2=0.59+/-0.03 (progessive retinal atrophy) in the threshold model. The additive genetic correlation between noncongenital cataract and progressive retinal atrophy was moderately positive (r(g)=0.54+/-0.08) in the threshold model. The number of examinations performed by the veterinary ophthalmologists was associated with slightly higher heritabilities for noncongenital cataract and considerably higher heritabilities for progressive retinal atrophy. The investigated PIED in the Entlebucher Mountain Dog are genetically influenced and the size of the genetic parameters estimated may be sensitive to the accuracy of the diagnosis and how the data were collected.

Animals↗