Wrinkly skin syndrome.
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Abnormalities, Multiple↗
Biomedical subjects
H Hamamy
Publications and source records attributed to H Hamamy.
Consanguineous marriages in Jordan: why is the rate changing with time?
The objective of this study was to explore the secular trend in consanguinity in Jordan and the subtypes of consanguineous marriages that may be undergoing a change. A total of 1032 individuals attending a diabetic clinic in Amman were interviewed. The questionnaire provided information on consanguinity status and date of marriage among three generations: the persons interviewed, their parents, parents of their spouses and their offspring. Data on consanguinity status among 5401 marriages was obtained. Generations were named generation 1 for marriages contracted before 1950, generation 2 for marriages contracted between 1950 and 1979, and generation 3 for marriages contracted after 1980. For generations 1, 2, and 3, first-cousin marriages constituted 20.2, 28.5 and 19.5% of all marriages, respectively, while the subtype of paternal parallel first-cousin marriages constituted 75.6, 60.3 and 43.3% of all first-cousin marriages, respectively. The offspring of first-cousin parents were significantly more prone to marry their relatives than the offspring of non-consanguineous parents, with rates of first-cousin marriages among offspring of first-cousin parents and non-related parents constituting 25.3 and 17.1% of all marriages, respectively. For generations 1, 2 and 3, the average coefficient of inbreeding was 0.0135, 0.02 and 0.0142, respectively. In conclusion, first-cousin marriage rate among a representative population from Amman showed a significant decline among marriages contracted after 1980 compared to marriages contracted between 1950 and 1979, but not to marriages contracted before 1950. The proportion of paternal parallel first cousins among first-cousin marriages showed a steady decline from one generation to the next.
Consanguinity↗
Hereditary disorders in the Eastern Mediterranean Region.
Hereditary diseases and congenital malformations have been reported to affect 2-5% of all live births. Available evidence suggests that genetic disorders are equally important also in countries of the Eastern Mediterranean Region. Considerable achievements have been made over the last two decades in controlling communicable diseases in the region. Concurrently, there has been a mounting awareness of the increasing importance of hereditary disorders. Certain genetically determined diseases such as the haemoglobinopathies and enzymopathies are extremely common in the region and the need to initiate public health measures for their control is increasingly being recognized. The following factors may contribute to the elevated prevalence of genetically determined disorders: the high consanguinity rates; the high frequency of haemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency; the trend of continuing to bear children up to menopause; the general lack of public awareness about genetic diseases; and the dearth of genetic services in the region. These and some other related issues are discussed in detail in this review article.
Chromosome Aberrations↗
Sister chromatid exchange frequencies in a group of individuals with unfavorable reproductive health.
Sister chromatid exchange (SCE) frequencies and other cytogenetic parameters were investigated in peripheral blood lymphocytes from 92 subjects comprising 44 parents of malformed offspring or repeated fetal wastage (Group I) and 48 controls, age and sex matched, having normal reproductive health (Group II). The karyotypes were normal and the mean mitotic indices were comparable in both groups. The mean frequency of SCE per metaphase in Group I (8.67 +/- 0.32) was significantly higher than the mean for group II (6.65 +/- 0.16), and the cellular replicative index in Group I (1.78 +/- 0.04) was significantly different from that of Group II (1.66 +/- 0.03). The results are discussed in the light of the present understanding of the etiology and mechanism of production of sister chromatid exchanges.
Abortion, Habitual↗