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H Haebara

Publications and source records attributed to H Haebara.

At least 19 recordsLinked to original sources
PubMed2000

Acinar cell carcinoma of the pancreas showing finger-print-like zymogen granules by electron microscopy: immunohistochemical study.

A rare case of finger-print-like zymogen granules shown by electron microscopy is reported. The patient was a 75-year-old man who was histologically and ultrastructurally confirmed to have acinar cell carcinoma of the pancreas. Frozen section and postmortem examination revealed that the tumor was made up of solid nests of cells resembling the appearance of normal pancreatic acini, showing polygonal cells which had round or oval nuclei, and rare mitotic figures. Zymogen-like granules, shown by eosinophilic granular staining, were abundant in the cytoplasm. Electron microscopy showed that the tumor cells were closely packed, occasionally forming small intercellular spaces resembling pancreatic acini (microtubules). The cytoplasm contained characteristic zymogen granules with dark-to-medium electron density, measuring 660 nm +/-213 SD in diameter. The granules of medium density were large, and showed finger-print-like patterns. Investigation of more cases is necessary to identify whether these finger-print-like patterns are an important factor in the genesis of acinar cell carcinoma.

Aged↗
PubMed2000

Neuropathology of auditory agnosia following bilateral temporal lobe lesions: a case study.

Our patient was first diagnosed with auditory agnosia following his second cerebral vascular accident (CVA) in 1975 when he was 37 years old. Comprehensive follow-up examinations of auditory function were periodically conducted until his sudden death 15 years later. His brain was studied postmortem for neuropathology. Initial pure-tone audiometry revealed moderate sensorineural hearing loss in the right ear and mild sensorineural hearing loss in the left ear. However, repeated pure-tone audiometry revealed that thresholds became progressively poorer over time, bilaterally. Speech audiometry of both ears consistently revealed that the patient was unable to discriminate any monosyllabic words (i.e. speech intelligibility scores were 0%, bilaterally). In general, speech and hearing tests demonstrated that he could not comprehend spoken words, but could comprehend written commands and gestures. Postmortem neuropathological study of the left hemisphere revealed total defect and neuronal loss of the superior temporal gyrus, including Heschl's gyrus, and total gliosis of the medial geniculate body. In the right hemisphere, examination revealed subcortical necrosis, gliosis in the centre of the superior temporal gyrus and partial gliosis of the medial geniculate body. The pathological examination supports clinical results in which the patient's imperception of speech sounds, music and environmental sounds could be caused by progressive degeneration of bilateral medial geniculate bodies.

Adult↗
PubMed2000

Heart disease in Friedreich's ataxia: observation of a case for half a century.

A case of Friedreich's ataxia was followed for 47 years, beginning in 1930; this patient had an abnormal electrocardiogram (flat or inverted T waves in leads II and III with prolonged QT interval) from the very beginning of the onset of neurological symptoms. Cardiac and neurological disturbances progressed slowly but steadily, and the patient died suddenly at the age of 67. The autopsy revealed typical findings of Friedreich's ataxia and hypertrophic cardiomyopathy with thickened left ventricular wall and myocardial fiber disarray. To the authors' knowledge, this is the longest continuous follow-up study of Friedreich's ataxia, and it will provide invaluable information on the natural history and development of the cardiac and neurological disorders in this condition.

Adult↗
PubMed2000

A diffuse alveolar hemorrhage in a human T-lymphotropic virus type I carrier with acute cerebellar ataxia and interstitial pneumonitis: an autopsy case report.

A 76-year-old HTLV-I-positive male with acute cerebellar ataxia was suffering from dyspnea on exertion. Chest CT suggested interstitial pneumonitis. Methylprednisolone pulse therapy improved his symptoms and chest CT findings. Twelve months after discharge, when the prednisolone dose was tapered to 5 mg every other day, his lung lesion recurred. The lesion responded initially to steroid therapy. However, hypoxemia intractable to steroid pulse therapy developed and the patient died of respiratory failure. The autopsy revealed diffuse alveolar hemorrhage with no finding of vasculitis. This is the first case report of diffuse alveolar hemorrhage in an HTLV-I carrier.

Acute Disease↗
PubMed1997

Temporal bone pathology of acoustic neuroma correlating with presence of electrocochleography and absence of auditory brainstem response.

The temporal bone pathology of a 74-year-old female affected by vestibular schwannoma was compared with findings of auditory brainstem response and electrocochleography. At age 71, she complained of hearing loss in the left ear in which pure tone audiometry revealed threshold elevation in the middle- and high-frequency range. Temporal bone CT scanning revealed a medium-sized cerebellopontine angle tumour in the left ear. ABR showed no response in the left ear, but the electrocochleography showed clear compound action potentials. Three years later, at age 74, she died of metastatic lung cancer and sepsis. The left temporal bone pathology consisted primarily of a large vestibular schwannoma occupying the internal auditory meatus. The organ of Corti was well preserved in each turn. In the modiolus, the numbers of spiral ganglion cells and cochlear nerve fibres in each turn were decreased. These histological findings suggest that clear compound action potentials were recorded from the distal portion of the cochlear nerve in spite of the presence of the vestibular schwannoma, but ABR could not be detected because of the blockade of the proximal portion of the cochlear nerve by the vestibular schwannoma.

Aged↗
PubMed1996

[A case of congenital brain tumor diagnosed during follow-up of neonatal intracranial hemorrhage].

We describe a three-year-old girl whose growing congenital brain tumor may have been responsible for her perinatal intracranial hemorrhage. The patient, born after an uneventful pregnancy and delivery, had an intracranial hemorrhage in the right frontal area, including the basal ganglia, as a newborn. Her only symptoms at that time were vomiting and fever. She improved both, clinically and neuroradiologically during the following weeks, and except for mild left hemiparesis, the patient developed with no other apparent neurological deficits. However, a follow-up brain CT scan at 3 years of age, disclosed a heterogeneous tumor with a 5 cm diameter in the same right frontal area as the neonatal hemorrhage. The tumor was surgically removed, and diagnosed as a benign mixed tumor composed of differentiated astrocytoma and meningioma elements. It is conceivable that the brain tumor may have been growing rather slowly since an early fetal stage. This case indicates the need of being aware that neonatal intracranial hemorrhages may be caused by bleeding of congenital brain tumors.

Astrocytoma↗
PubMed1995

Auditory brainstem response and temporal bone and brainstem pathology in brainstem death, with special reference to autolysis of red blood cells.

We studied the pathological changes in the temporal bone and brainstem, with particular attention to the autolysis of red blood cells in and around the blood vessels, in six cases of brainstem death determined by auditory brainstem responses (ABRs). Our findings showed that the cochlea, the visceral organs and the spinal cord below a certain level of the cervical segments continued to live after brainstem death. Red blood cells in the vessels of the brainstem and cerebellum exhibited severe autolysis, whereas most red blood cells in the cochlea were preserved. Our findings of autolytic changes in red blood cells in the brainstem, and the preservation of red blood cells in the cochlea, imply initial loss of brainstem function and delayed loss of cochlear function after prolonged absence of ABRs.

Adolescent↗
PubMed1987

A distinctive distribution of reactive astroglia in the precentral cortex in amyotrophic lateral sclerosis.

Morphological changes in astrocytes have been studied in the primary motor cortex of persons dying with or without amyotrophic lateral sclerosis (ALS). Glial fibrillary acidic protein (GFAP) and S-100 protein were used as immunohistochemical markers for reactive astroglia. In 12 brains of individuals without neurological disease glial cells showing moderate immunoreactivity for both GFAP and S-100 protein were uniformly distributed in the primary motor cortex in the upper regions of layer I and layer II. In 8 of 11 ALS cases, intensely immunoreactive cells were additionally found to occur and were scattered irregularly, mostly in layers II and III, but occasionally in layers IV and V. Clusters of these intensely positive cells occurred in patches about 200-400 micron in diameter, each containing about 6 to greater than 20 such cells. GFAP-positive astrocytes were seen in some of the 36 brains from persons with neurological problems other than ALS but the pattern was different. The abnormal appearance of clusters of positive astrocytes of the primary motor cortex may be intimately associated with the ALS disease process.

Adult↗
PubMed1987

An immunohistochemical study of intracranial germ cell tumours.

Histologically verified intracranial tumours, mainly germ cell tumours of the pineal and suprasellar regions, were studied immunohistochemically using anti-serum of alpha fetoprotein (AFP), human chorionic gonadotropin (HCG), carcinoembryonic antigen (CEA), human placental lactogen (HPL), pregnancy specific beta-1 glycoprotein (SP-1), glial fibrillary acidic protein (GFAP), S-100 and neuron specific enolase (NSE). In germinomas, HCG positive cells were occasionally demonstrated in cells presenting as syncytiotrophoblastic giant cells (STGC), and GFAP and S-100 positive cells were found in the surrounding gliotic lesions. Teratomas were positive for CEA in their epithelial components. Endodermal sinus tumours were positive for AFP, choriocarcinomas for HCG and SP-1, and embryonal carcinomas for AFP, HCG and SP-1. HCG and SP-1 positive cells were demonstrated in STGC. As for the relationship between serum AFP level and tissue localization, many cases presenting a serum AFP level exceeding 220 ng/ml were positive for AFP in tumour tissue.

Adolescent↗
PubMed1987

Local bone resorption induced by serially transplantable human renal cell carcinoma in nude mice.

The high incidence of metastatic bone disease in urological cancer makes it necessary for clinicians to look for a valid experimental model to investigate the basic interactions between cancer cells and bone in order to improve the treatment. A new model of bone resorption was defined, namely the subcutaneous injection of tumor cell suspensions of serially transplanted renal cell carcinoma in nude mice after disruption of the periosteum of the calvaria. The tumor induced osteolysis associated with osteoclast proliferation with reactive bone formation. The X-p film from nude mice calvaria showed the same multiple osteolytic punched-out lesions as those of the patient's skull.

Aged↗
PubMed1986

Primary intracranial choriocarcinoma arising from the pituitary fossa. Report of an autopsy case with literature review.

A 12-year-old Japanese girl with a primary intracranial choriocarcinoma arising from the pituitary fossa is reported. There was a markedly high level of serum human chorionic gonadotropin (HCG) throughout the clinical course. Postmortem examination revealed metastatic lesions found in the cerebellum, dura mater, skull (clivus, sphenoidal bone), and lungs. Immunohistochemical characteristics of the primary intracranial tumor and lung lesions disclosed positive stainings for HCG and HCG-beta in the neoplastic syncytiotrophoblastic cells.

Brain Neoplasms↗
PubMed1985

Astroblastoma of pure type.

A rare case of astroblastoma of the pure type occurring in the left occipital lobe of a 54-year-old female is reported. The predominant histologic feature was that of perivascular pseudorosettes. The tumor tissues were not stained by the Mallory's phosphotungstic acid-hematoxylin, but the perikarya of some tumor cells were positively stained for the glial fibrillary acidic protein.

Astrocytoma↗
PubMed1983

Intraperiosteal osteoid osteoma. A case report.

A painful intraperiosteal osteoid osteoma of the femur occurred in a 36-year-old man. Histologically, the tumor was encapsulated by the periosteum. The pain was relieved by removal of the tumor. Thirty-four months after operation, there has been no recurrence. Osteoid osteoma in this location does not appear to have been reported previously.

Adult↗
PubMed1982

Benign pedunculated intraluminal tumor of the esophagus.

Benign pedunculated intraluminal tumor of the esophagus is extremely rare. Although the correct diagnosis of this tumor is difficult, it should be extirpated early because, if untreated, it may result in death of the patient by progressive emaciation, bleeding from erosions, or acute airway obstruction. We present a case rescued from suffocation caused by regurgitation of a giant esophageal tumor. In the discussion on the difficulty of diagnosis, the necessity of repeated examination is emphasized. The classification of benign esophageal tumors is also discussed.

Airway Obstruction↗