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Biomedical subjects

H H Parving

Publications and source records attributed to H H Parving.

At least 289 records · Page 16Linked to original sources
PubMed1976

The effect of metabolic regulation on microvascular permeability to small and large molecules in short-term juvenile diabetics.

The microvascular permeability to small and large molecules was studied during good and poor metabolic regulation in ten short duration juvenile diabetics. The following variables were measured; daily urinary albumin and beta2-microglobulin-excretion rates, whole body transcapillary escape rate of albumin (TER), glomerular filtration rate (GFR), capillary filtration coefficient (CFC), and capillary diffusion capacity (CDC). The urinary albumin and beta2-microglobulin concentration were measured by sensitive radioimmunoassays; TER was detemined from the initial disappearance of intravenously injected 125I-labelled human serum albumin; GFR was measured on the forearm by straingauge plethysmography and CDS for 51Cr-EDTA clearance; CFC was measured on the forearm by straingauge plethysmography and CDC, for 51Cr-EDTA was determined in the jyperaemic anterio tibial muscle by the local clearance technique. All the above mentioned variables, except CDC, were significantly increased during poor metabolic regulation, indicating a functional microangiopathy. The mechanisms of these alterations appear to be increased filtration pressure in the microcirculation and/or increased porosity of the microvasculature. The findings of increased microvascular albumin passage are compatible with the hypothesis that the organic - histologicallly demonstrated - diabetic microangiopathy is a long-term effect of periods of increased extravasation of plasma proteins, with subsequent protein deposition in the microvascular wall, i.e. the concept to plasmatic vasculosis.

Adolescent↗
PubMed1976

Plasma volume, intravascular albumin and its transcapillary escape rate in patients with extensive skin disease.

Plasma volume and plasma concentration and transcapillary escape rate of albumin (TER alb), i.e. the fraction of intravascular mass of albumin that passes to the extravascular space per unit time, were determined using 125I-labelled human albumin in eight patients with extensive skin disease. Plasma volume and plasma albumin concentration were reduced (P less than 0-05). Thus the intravascular albumin mass was moderately decreased to an average of 0-55 +/- 0-06 (s.d.) g/cm height compared with a normal mean value of 0-77 +/- 0-07 (s.d.) g/cm. This 29% decrease is statistically significant (P less than 0-001). The transcapillary escape rate of albumin (TER alb) was significantly elevated, mean 8-6 +/- 1-1 (s.d.) % X h-1, as compared to normal subjects, mean 5-6 +/- 1-1 (s.d.) % X h-1, (+54%, P less than 0-001). The same patients were studied again after a 1-week treatment with prednisone, 25-60 mg per day. Plasma albumin concentration, plasma volume and intravascular mass of albumin were unchanged, while TER alb decreased significantly during treatment, mean 5-9 +/- 0-8 (s.d.) % X h-1, (P less than 0-01). It is suggested that displacement of albumin into the skin and loss of albumin from the skin are the dominating mechanisms of the reduction in the intravascular albumin mass in patients with extensive skin disease.

Aged↗
PubMed1976

Transcapillary escape rate of albumin and right atrial pressure in chronic congestive heart failure before and after treatment.

The transcapillary escape rate of albumin (TERalb), i.e., the fraction of intravascular mass of albumin that passes to the extravascular space per unit of time, was determined from the disappearance of intravenously injected 125I-labeled human serum albumin during the first 60 minutes after injection in 10 subjects with chronic right heart failure. The investigation was repeated after sodium and water depletion. Before treatment TERalb was significantly elevated (mean 8.3 +/- 1.6% (SD)/hour, in comparison to values for normal subjects (mean 5.4 +/- 1.1%/hour, P less than 0.001). With treatment TERalb decreased significantly (mean 5.9 +/- 1.2%/hour, P less than 0.01). Right atrial pressure decreased from an average of 10 mm Hg to 6 mm Hg during treatment. A statistically significant, positive correlation was found between TERalb and right atrial pressure (r = 0.77, P less than 0.001). Our results best can be explained by increased filtration, mainly through the venous end of the microvasculature, due to the increased venous pressure in heart failure.

Adult↗
PubMed1976

Increased microvascular permeability to plasma proteins in short- and long-term juvenile diabetics.

The present findings of increased microvascular protein passage are compatible with the hypothesis that the organic, histologically demonstrated diabetic microangiopathy is a long-term effect of periods of increased extravasation of plasma proteins, with subsequent protein deposition in the microvascular wall, i.e., the concept of plasmatic vasculosis. Arterial hypertension, frequently present in diabetes, enhances the development of arteriolar hyalinosis. Effective treatment of diabetes and hypertension arrests development of the microvascular lesions.

Adolescent↗
PubMed1975

Increased metabolic turnover rate and transcapillary escape rate of albumin in long-term juvenile diabetics.

The metabolic turnover rate and transcapillary escape rate of albumin were studied with 131I-labelled human albumin in nine patients with long-term diabetes mellitus. Retinopathy was present in all patients and nephropathy in four. Plasma albumin concentration and plasma volume were reduced (P smaller than 0.05). The previously reported decrease in the intravascular albumin mass in long-term diabetics was thus confirmed by an average of 59.0 g/m2 surface area, compared with a normal value of 71.7 g/m2-(minus18%) (P smaller than 0.005). The albumin metabolic rate was increased, the fractional disappearance rate being an average 13.2% of the intravascular albumin mass per 24 hr, compared with a normal value of 8.4% (+ 57%) (P smaller 0.001). The rate of synthesis was 7.7 g - 24 h-1 - m-2 in contrast to a normal rate of 6.2 g - 24 h-1 - m-2 (+24%) (P smaller 0.001). Total body albumin mass was decreased proportionally to the intravascular mass. Confirming previous observations, we found an increase in the transcapillary escape rate of albumin (fraction of intravascular albumin mass passing to the extravascular space per unit time) from a normal average of 5.6% - hr-1 to 7.4% - hr-1 (+32%) (P ssmaller than 0.001). This finding can best be explained by an increased microvascular permeability to plasma proteins. A positive correlation between the transcapillary escape rate and fractional disappearance rate of albumin was demonstrated ( r equals 0.74; P smaller than 0.01). This supports the concept that albumin is catabolized in connection with its permeation through the microvascular endothelium.

Adult↗